Immunology of Infectious Disease News Volume 11.31 | Aug 9 2023

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    2023-08-09 | IIDN 11.31


    Immunology of Infectious Disease News by STEMCELL Technologies
    Vol. 11.31 – 9 August, 2023
    TOP STORY

    SARS-CoV-2 Omicron BA.1 Breakthrough Infection Drives Late Remodeling of the Memory B Cell Repertoire in Vaccinated Individuals

    Researchers studied the memory B cell response up to six months after SARS-CoV-2 Omicron BA.1 breakthrough infection in individuals previously vaccinated with three doses of the COVID-19 mRNA vaccine.
    [Immunity]

    AbstractGraphical Abstract
    Learn how the SARS-CoV-2 genotype impacts viral load, transmission, and spread with Dr. Judd F. Hultquist.
    PUBLICATIONSRanked by the impact factor of the journal

    SARS-CoV-2 Hijacks Neutralizing Dimeric IgA for Nasal Infection and Injury in Syrian Hamsters

    Investigators reported the efficacy of receptor binding domain-specific monomeric B8-mIgA1 and B8-mIgA2, and dimeric B8-dIgA1, B8-dIgA2 and TH335-dIgA1 against intranasal SARS-CoV-2 challenge in Syrian hamsters.
    [Emerging Microbes & Infections]

    Full Article

    Viral Anti-Inflammatory Serpin Reduces Immuno-Coagulopathic Pathology in SARS-CoV-2 Mouse Models of Infection

    Researchers described systemic treatment with purified PEGylated Serp-1 as a therapy for immuno-coagulopathic complications during acute respiratory distress syndrome.
    [EMBO Molecular Medicine]

    Full ArticleGraphical Abstract

    Differential Effects of SARS-CoV-2 Variants on Central Nervous System Cells and Blood–Brain Barrier Functions

    Scientists used primary human pericytes, fetal astrocytes, endothelial cells and a microglial cell line to investigate the effect of several SARS-CoV-2 variants of concern or interest on their functional activities.
    [Journal of Neuroinflammation]

    Full ArticlePress Release

    Single-Dose Mucosal Replicon-Particle Vaccine Protects against Lethal Nipah Virus Infection Up to 3 Days after Vaccination

    The authors reported on the clinical impact of a novel Nipah virus-derived nonspreading replicon particle lacking the fusion protein gene as a vaccine in three small animal models of disease.
    [Science Advances]

    Full Article

    Entry Receptor LDLRAD3 Is Required for Venezuelan Equine Encephalitis Virus Peripheral Infection and Neurotropism Leading to Pathogenesis in Mice

    Using wild-type and Ldlrad3-deficient mice, scientists defined a critical role for low-density lipoprotein receptor class A domain-containing 3 (LDLRAD3) in controlling steps in venezuelan equine encephalitis virus infection, pathogenesis, and neurotropism.
    [Cell Reports]

    Full ArticleGraphical Abstract

    The Ubiquitin Ligase TRIM32 Promotes the Autophagic Response to Mycobacterium tuberculosis Infection in Macrophages

    Researchers investigated the role tripartite motif (TRIM) proteins whose expression was modulated in response to Mycobacterium tuberculosis or BCG infection of primary macrophages.
    [Cell Death & Disease]

    Full Article

    APOBEC3 Degradation Is the Primary Function of HIV-1 Vif Determining Virion Infectivity in the Myeloid Cell Line THP-1

    Scientists indicated that the primary function of virion infectivity factor (Vif) during infectious HIV-1 production from THP-1 cells was the targeting and degradation of A3 enzymes.
    [mBio]

    Full Article

    PROTAC Targeting Cyclophilin A Controls Virus-Induced Cytokine Storm

    Three proteolysis-targeting chimeras (PROTACs) targeting cyclophilin A (CypA) were designed. These PROTACs bound to CypA, enhanced its ubiquitination and promoted its degradation in both cell lines and mouse organs.
    [iScience]

    AbstractFull Article
    Graphical Abstract
    A person presenting slides at a scientific conference
    REVIEWS

    The Emerging Role of Heart-on-a-Chip Systems in Delineating Mechanisms of SARS-CoV-2-Induced Cardiac Dysfunction

    The authors summarize the current understanding of potential mechanisms that drive SARS-CoV-2-induced cardiac dysfunction based on in vitro studies.
    [Bioengineering & Translational Medicine]

    Full Article
    INDUSTRY AND POLICY NEWS

    Dr. Hans-Peter Kiem Awarded amfAR Grant for Research on HIV Gene Therapy

    Dr. Hans-Peter Kiem was awarded $480,000 by amfAR, The Foundation for AIDS Research, to support the next stage of his work. Dr. Kiem is pursuing an in vivo gene therapy that confers HIV resistance to a specific subset of a patient’s hematopoietic stem cells.
    [Fred Hutchinson Cancer Center]

    Press Release
    FEATURED EVENT

    17th Vaccine Congress

    September 24 – 27, 2023
    Glasgow, Scotland

    > See All Events

    JOB OPPORTUNITIES

    Principal Investigators – Molecular Cell Science

    Center for Excellence in Molecular Cell Science – Shanghai, China

    Assistant Professor – Immunology

    Harvard Medical School – Boston, Massachusetts, United States

    Postdoctoral Appointee – Virologist/Molecular Biologist

    Sandia National Laboratories – Livermore, California, United States

    Postdoctoral Position – HIV Persistence and Neuroimmunology

    University of California, Berkeley – Berkeley, California, United States

    Postdoctoral Fellow – Brain Disease Mechanisms

    Harvard Medical School-Brigham and Women’s Hospital – Boston, Massachusetts, United States

    > See All Jobs

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