 | | Vol. 11.32 – 23 August, 2023 |
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| Researchers developed germ-free mice systemically reconstituted with human immune cells and used them to evaluate the role of the resident microbiome in the acquisition, replication, and pathogenesis of two human-specific pathogens, Epstein–Barr virus and HIV.
[Nature Biotechnology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Investigators resolved the near-atomic cryo-EM structure of respiratory syncytial virus (RSV) nucleoprotein-RNA that represented roughly one turn of the helical assembly that unveiled critical interaction interfaces of RSV nucleocapsid and may facilitate the development of RSV antiviral therapy.
[Signal Transduction And Targeted Therapy] |
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| Researchers measured the peripheral immune profiles of 206 vaccinated or unvaccinated adults to determine how baseline variations in the cellular and humoral immune compartments contribute independently or synergistically to the risk of developing symptomatic influenza.
[Nature Immunology] |
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| Scientists showed influenza A virus infection blocked defensive alveolar wall liquid secretion and induced airspace liquid absorption, thereby reversing normal alveolar liquid dynamics and inhibiting alveolar clearance of inhaled Staphylococcus aureus.
[Journal Of Clinical Investigation] |
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| The effects of calcitonin gene-related peptide (CGRP) on bacterial meningitis (BM) and the underlying mechanisms were investigated in BM mice in vivo and macrophages in vitro.
[Journal Of Infectious Diseases] |
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| Investigators developed a mixed nano micelle drug delivery system for simultaneous targeting of HIV-infected CD4+ T cells with two drugs, suberoylanilide hydroxamic acid and phorbol 12-myristate 13-acetate.
[ACS Applied Bio Materials] |
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| Researchers quantified reinfection risks for patients undergoing distinct antineoplastic therapies, given alternative frequencies of boosting with Pfizer-BioNTech BNT162b2.
[JNCI-Journal Of The National Cancer Institute] |
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| Individuals 70 years or older who received a primary two-dose schedule with AZD1222 and booster third dose with mRNA vaccine achieved significantly lower neutralizing antibody responses against SARS-CoV-2 spike pseudotyped virus compared with those younger than 70 at 1-month post booster.
[Cell Reports] |
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| Through llama immunization campaigns, scientists identified single-domain antibodies that were cross-reactive against multiple emergent coronaviruses. Importantly, a number of these antibodies showed sub-nanomolar potency towards all SARS-like viruses including emergent CoV-2 variants.
[Scientific Reports] |
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| The authors summarize recent progress and highlight outstanding questions regarding the emerging role of mucosal-associated invariant T (MAIT) cells in antiviral immunity.
[Journal Of Immunology] |
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| Tonix Pharmaceuticals Holding Corp. announced that it received the official written response from a Type B pre-Investigational New Drug Application meeting with the US FDA to develop TNX-8011 as a potential vaccine to protect against mpox disease and smallpox.
[Tonix Pharmaceuticals Holding Corp.] |
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| September 17 – 20, 2023
Surrey, England, United Kingdom |
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| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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| | The Scripps Research Institute – La Jolla, California, United States |
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| | WMU Homer Stryker MD School of Medicine – Kalamazoo, Michigan, United States |
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| | Creative Biolabs – New York, New York, United States |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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