 | | Vol. 11.34 – 30 August, 2023 |
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| In a phase II, open-label, randomized clinical trial with sequentially enrolled stages, researchers assessed the safety and immunogenicity of a second boost with monovalent or bivalent variant vaccines from mRNA and protein-based platforms targeting wild-type, Beta, Delta, and Omicron BA.1 spike antigens.
[Nature Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators utilized a spatial transcriptome atlas to identify pulmonary microstructure-specific COVID-19 gene signatures during the acute phase of lung infection in cynomolgus macaques.
[Communications Biology] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Investigators presented the cryo-EM structures of HIV-1 viral infectivity factor (Vif) in complex with human A3H, CBF-β, and components of cullin-5 (CUL5) ubiquitin ligase. Vif nucleated the entire complex by directly binding four human proteins, A3H, CBF-β, CUL5, and ELOC.
[Nature Communications] |
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| Researchers studied lung-resident alveolar macrophages (AMs) prechallenged with either the bacterial endotoxin or with Pseudomonas aeruginosa and observed that these trained AMs showed greater resilience to pathogen-induced cell death.
[Journal Of Experimental Medicine] |
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| By using ovalbumin recombinant Listeria monocytogenes (LmOVA), scientists provided evidence that OVA-specific T cells were transferred from the mother to the fetus, which was associated with increased activation of T cells and a milder course of postnatal infection in the offspring.
[EMBO Reports] |
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| Investigators explored the mechanism of respiratory syncytial virus (RSV) regulating naive T cell differentiation through dendritic cells. They generated a Lentivirus shRNA expression vector to knock down CHI3L1 in mouse lungs and bone marrow-derived dendritic cells.
[International Immunopharmacology] |
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| Researchers analyzed extracellular vesicles (EV) in excretory-secretory products released by Paragonimus kellicotti adult worms cultured in vitro and EV isolated from lung cyst fluid recovered from infected gerbils.
[Scientific Reports] |
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| Scientists obtained a novel subunit vaccine that combines two regions of Zika genome, domain III of the envelope and the capsid, in a chimeric protein in E. coli bacteria.
[Vaccine] |
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| Researchers investigated the changes of toll-like receptor 4, proinflammatory cytokine expression, hepatitis B virus surface antigen, and hepatitis B virus envelope antigen expression as well as innate immune cell percentages in a mouse model of persistent hepatitis B virus infection.
[Viral Immunology] |
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| The authors summarize the gene regulation and post-translational modification of angiotensin-converting enzyme 2 (ACE2) in chronic disease and COVID-19. Understanding the regulation and modification of ACE2 may help to develop prevention or treatment strategies for ACE2-mediated diseases.
[Journal Of Biomedical Science] |
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| | Immune Therapeutics, Inc. d/b/a Biostax Corp. with Immgenuity, Inc. will focus on using Immgenuity’s IMTV014 and Biostax’s Lodonal™ and JKB-122 both independently and together to determine if the immune modulatory effects of the drug therapies combined can achieve remission with HIV patients.
[Immune Therapeutics, Inc.] |
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| September 27 – 30, 2023
Boston, Massachusetts, United States |
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| | Montana State University – Bozeman, Montana, United States |
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| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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| | The Scripps Research Institute – La Jolla, California, United States |
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| | WMU Homer Stryker MD School of Medicine – Kalamazoo, Michigan, United States |
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| | Creative Biolabs – New York, New York, United States |
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