 | | Vol. 11.36 – 13 September, 2023 |
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| Using Ebola virus (EBOV) L polymerase as a representative, investigators showed that de novo replication of L polymerase was controlled by the specific 3’ leader sequence of EBOV genome in an enzymatic assay, and formation of at least three base pairs can effectively drive the elongation process of RNA synthesis.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers presented the crystal structure of a main protease of SARS-CoV-2 point mutant (H163A) that showed an oxidized conformation with the catalytic cysteine in a disulfide bond.
[Nature Communications] |
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| Investigators expressed Orf9b in human HEK293 cells and observed an Orf9b-mediated depletion of mitochondrial proteins, particularly in respiring cells.
[Journal Of Cell Biology] |
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| Neutralizing antibody responses in sera, venous blood, and fingerstick blood stored on filter paper were measured. Samples were collected from SARS-CoV-2 acutely infected individuals, SARS-CoV-2 convalescent individuals, and SARS-CoV-2 vaccinated individuals.
[Scientific Reports] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Researchers demonstrated the mosaic vaccines induced stronger cross-reactive antibodies and robust more T cell responses compared to the quadrivalent inactivated influenza vaccine.
[NPJ Vaccines] |
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| Investigators reported that the human papillomavirus type 8 (HPV8) E6 protein could subvert Hippo signaling by activating Transcriptional Enhanced Associate Domain transcriptional programs that inhibited the expression of keratinocyte differentiation markers.
[mBio] |
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| To explore cell composition and CD8+ T cell infiltration during cerebral malaria, single-cell RNA sequencing was performed on the brainstems of healthy and experimental cerebral malaria mice.
[CNS Neuroscience & Therapeutics] |
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| Researchers selected the MOMP protein of C. pneumoniae as the antigen target, predicted the T and B cell epitopes of the MOMP protein and then connected the CTLA-4 extracellular structure with the predicted dominant epitopes by various linkers to construct a multi-epitope vaccine.
[Scientific Reports] |
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| To evaluate scalp bacteria’s effect on human keratinocyte cellular activity, including that of the hair follicular keratinocytes, the expression of several longevity genes was examined using HaCaT cells.
[Bioscience, Biotechnology, and Biochemistry] |
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| The authors explore how HIV has evolved to manipulate some of the physiological roles of these cells, thereby gaining access to strategic cellular niches that are critical for the spread and pathogenesis of HIV infection.
[Reviews In Medical Virology] |
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| GeoVax Labs, Inc. announced that it has met the enrollment target for its Phase II clinical trial evaluating GEO-CM04S1 as a booster for healthy patients who have previously received the Pfizer or Moderna mRNA vaccine
[Geovax Labs, Inc.] |
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| October 1 – 4, 2023
Whistler, British Columbia, Canada |
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| | National University of Singapore – Kent Ridge, Singapore |
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| | École polytechnique fédérale de Lausanne – Lausanne, Switzerland |
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| | George Washington University – Washington, District of Columbia, United States |
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| | Montana State University – Bozeman, Montana, United States |
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| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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