Immunology of Infectious Disease News Volume 11.38 | Sep 27 2023

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    2023-09-27 | IIDN 11.38


    Immunology of Infectious Disease News by STEMCELL Technologies
    Vol. 11.38 – 27 September, 2023
    TOP STORY

    A Molnupiravir-Associated Mutational Signature in Global SARS-CoV-2 Genomes

    Scientists showed that SARS-CoV-2 sequencing databases contained extensive evidence of molnupiravir mutagenesis.
    [Nature]

    AbstractPress Release
    Learn how to stay motivated in research.
    PUBLICATIONSRanked by the impact factor of the journal

    Baseline Gut Microbiota and Metabolome Predict Durable Immunogenicity to SARS-CoV-2 Vaccines

    Investigators identified potential microbiota-based adjuvants that may extend the durability of immune responses to SARS-CoV-2 vaccines.
    [Signal Transduction And Targeted Therapy]

    Full Article

    A Computationally Designed Antigen Eliciting Broad Humoral Responses against SARS-CoV-2 and Related Sarbecoviruses

    Researchers showed that a single antigen based on the receptor binding domain of the spike protein of sarbecoviruses elicited broad humoral responses against SARS-CoV-1, SARS-CoV-2, WIV16, and RaTG13 in mice, rabbits, and guinea pigs.
    [Nature Biomedical Engineering]

    Full ArticlePress Release

    Previous Infection with Seasonal Coronaviruses Does Not Protect Male Syrian Hamsters from Challenge with SARS-CoV-2

    Hamsters were initially inoculated with seasonal coronaviruses, or SARS-CoV-2 pango B lineage virus, then challenged with SARS-CoV-2 pango B lineage virus, or SARS-CoV-2 variants Beta or Omicron.
    [Nature Communications]

    Full Article

    Green Synthesis, Characterization, Anti-SARS-CoV-2 Entry, and Replication of Lactoferrin-Coated Zinc Nanoparticles with Halting Lung Fibrosis Induced in Adult Male Albino Rats

    Lactoferrin zinc nanoparticles showed potent in vitro retardation for SARS-CoV-2 entry to host cells by binding to the ACE2-receptor and spike protein receptor binding domain at IC50 values of 59.66 and μg/mL, respectively.
    [Scientific Reports]

    Full Article

    Initial Productive and Latent HIV Infections Originate In Vivo by Infection of Resting T Cells

    Productively and latently HIV-infected cells could originate by direct infection of resting CD4+ T cell populations in lymphoid tissues in Fiebig I, the earliest stage of detectable HIV infection.
    [Journal Of Clinical Investigation]

    AbstractGraphical Abstract

    Epithelial Plasticity and Innate Immune Activation Promote Lung Tissue Remodeling Following Respiratory Viral Infection

    Researchers showed that a subset of distal airway secretory cells, intralobar serous cells, were activated to assume basal cell fates following influenza virus infection.
    [Nature Communications]

    Full Article

    Chimeric Hemagglutinin Split Vaccines Elicit Broadly Cross-Reactive Antibodies and Protection Against Group 2 Influenza Viruses in Mice

    Scientists showed that immunization with group 2 chimeric hemagglutinin (HA) split vaccines in combination with the CpG 1018 adjuvant elicited broadly cross-reactive antibodies against all group 2 HAs, as well as systemic and local antigen-specific T cell responses.
    [Science Advances]

    Full Article

    Self-Assembled Virus-Like Particle Vaccines via Fluorophilic Interactions Enable Infection Mimicry and Immune Protection

    A novel virus-like particle platform was developed that could mimic infection and confer influenza protection through fluorination-driven self-assembly.
    [Advanced Healthcare Materials]

    Abstract
    An overview of human NK cell receptors, activation, and biological function. Download your free wallchart now.
    REVIEWS

    The Role of Cell Death in SARS-CoV-2 Infection

    The authors summarize the existing evidence concerning the molecular modulation of cell death in SARS-CoV-2 infection as well as viral-host interactions, which may shed new light on antiviral therapy against SARS-CoV-2.
    [Signal Transduction And Targeted Therapy]

    Full Article
    INDUSTRY AND POLICY NEWS

    BioNTech Secures $90M from CEPI to Partner on Mpox Vaccine As It Enters Clinic

    The German biotech is partnering with the Center for Epidemic Preparedness Innovations, accepting up to $90 million from the foundation as part of a broader pandemic preparation initiative.
    [Fierce Biotech]

    Press Release
    FEATURED EVENT

    Cell Symposia: Structural Biology from the Nanoscale to Cellular Mesoscale

    November 3 – 5, 2023
    Huangshan, China

    > See All Events

    JOB OPPORTUNITIES

    Research Opportunities – Pediatrics Infectious Diseases

    University of Washington – Medical Lake, Washington, United States

    Postdoctoral Position – Mucosal Immunity

    Stanford University – Stanford, California, United States

    Postdoctoral Associate – NMR-based Metabolomics and Metabolomic Imaging

    Massachusetts General Hospital – Boston, Massachusetts, United States

    Student Assistant – HIV Research

    Rutgers University – New Brunswick, New Jersey, United States

    Clinical/Non-Clinical Senior Lecturer – Experimental Medicine

    King’s College London – London, England, United Kingdom

    > See All Jobs

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