 | | Vol. 11.40 – 11 October, 2023 |
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| Scientists explored the diagnostic and therapeutic potential of MOTS-c in hepatitis B virus-related diseases and its molecular mechanism.
[Gut] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers developed an infection-competent human vascular organoid from pluripotent stem cells for modeling endotheliopathy. Longitudinal serum proteome analysis identified aberrant complement signature in critically ill patients driven by the amplification cycle regulated by complement factor B and D.
[Cell Stem Cell] |
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| The “Indoor Transmission of COVID-19” trial aimed to assess the risk of transmission of SARS-CoV-2 and other respiratory viruses during an indoor clubbing event among participants fully-vaccinated against COVID-19.
[Clinical Infectious Diseases] |
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| Investigators presented the high-resolution structure of stem-loop 4 of the 5′-untranslated region (UTR) of the SARS-CoV-2 genome solved by solution-state nuclear magnetic resonance spectroscopy.
[Nucleic Acids Research] |
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| By expressing the six-proline-stabilized prefusion spikes from three diverse SARS-CoV-2 strains in the MeV, MuV-JL1, and MuV-JL2 vaccine strains from MMR, researchers generated a MMS trivalent vaccine candidate.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Investigators used preclinical rodent models to establish the cross-protective and cross-neutralizing capacity of adenoviral-vectored vaccines expressing variants of concern-matched spike.
[NPJ Vaccines] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| This phase II, multi-center, double-blinded, randomized controlled trial compared high-dose trivalent influenza vaccine to standard-dose quadrivalent influenza vaccine in children 3–17 years old who were 3–35 months post-allogeneic hematopoietic cell transplant.
[Clinical Infectious Diseases] |
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| Scientists used CRISPR/Cas9 to generate homozygous gene edited chickens containing two ANP32A amino acid substitutions that prevented viral polymerase interaction.
[Nature Communications] |
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| Researchers documented the prevalence of nocturnal hypertension and isolated nocturnal hypertension and the clinical factors associated with these phenotypes.
[American Journal Of Hypertension] |
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| The authors examine the intersection of the HIV and SARS-CoV-2 pandemics. People with HIV are a heterogeneous group that differ in their degree of immune suppression, immune reconstitution, and viral control.
[Cellular & Molecular Immunology] |
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| This review of both in vivo and clinical studies has revealed a consistent decline in alpha diversity and increased dissimilarity in beta diversity of gut microbiota in comparison to healthy populations, observed during both the acute and post-infection phases of COVID-19.
[Life Sciences] |
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| Nipah, a deadly RNA virus that can spill over from bats to humans, has infected six people and killed two in the Indian state of Kerala since August. The virus can cause encephalitis — inflammation of the brain — which manifests as fever, headaches, vomiting and respiratory distress.
[Nature] |
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| The World Health Organization has endorsed a second malaria vaccine to protect children against the deadly disease, which killed 619,000 people in 2021. Researchers say that the vaccine, known as R21, is easier to make than the first-approved malaria vaccine, called RTS,S, and will be cheaper per dose.
[Nature] |
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| November 15 – 17, 2023
Seoul, Korea |
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| | University of Washington – Medical Lake, Washington, United States |
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| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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| | University of Washington – Medical Lake, Washington, United States |
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| | Stanford University – Stanford, California, United States |
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| | Massachusetts General Hospital – Boston, Massachusetts, United States |
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