 | | Vol. 11.42 – 25 October, 2023 |
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| Scientists demonstrated that unmodified red blood cell-derived extracellular vesicles could inhibit SARS-CoV-2 infection in a phosphatidylserine-dependent manner.
[ACS Nano] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers utilized transcriptomic and proteomic profiling to compare individuals who received two doses of Ad26.COV2.S with those vaccinated with BNT162b2 or mRNA-1273.
[Nature Communications] |
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| Investigators reported the application of ancestral sequence reconstruction on coronavirus spike protein, resulting in stable and highly soluble ancestral scaffold antigens.
[Nature Communications] |
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| This prospective cohort aimed to assess body composition, cardiopulmonary fitness, and long-term symptoms of overweight individuals affected by COVID-19. Participants were divided into three groups according to the severity of acute COVID-19: mild, moderate, and severe/critical cases.
[Scientific Reports] |
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| Researchers identified biological processes and pathways involved in various diseases which were most likely affected by COVID-19.
[Microbial Pathogenesis] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Researchers depleted innate and/or adaptive CD8+ lymphocytes in macaques and showed that loss of all CD8α+ cells significantly impaired early control of Mycobacterium tuberculosis infection, leading to increased granulomas, lung inflammation, and bacterial burden.
[Journal Of Experimental Medicine] |
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| Researchers identified a critical window of CD4+ T cell responses that were targeted by IL-27. Neutralization of IL-27 during acute infection with Plasmodium chabaudi expanded specific CD4+ T cells, which were maintained at high levels thereafter.
[EMBO Molecular Medicine] |
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| Scientists studied the differential expression of multiple human endogenous retroviruses (HERVs) families in the presence of HIV infection in the peripheral blood mononuclear cells of HIV-positive individuals, in HIV-infected cell lines, and in vitro HIV-infected macrophages/monocytes of healthy donors.
[Microbiology Spectrum] |
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| Investigators evaluated the combined effect of the pro-apoptotic protein rhTRAIL with the replication-competent wild-type HSV-1 virus in head and neck cancer cell lines.
[Scientific Reports] |
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| Scientists summarize the role of NF-κB activation during SARS-CoV-2 invasion and replication, particularly the angiotensin-converting enzyme 2-mediated NF-κB activation.
[Hypertension Research] |
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| The authors review strategies in hepatitis B virus (HBV) prevention among people living with HIV, focusing specifically on updates in HBV vaccination and chemoprophylaxis.
[Current HIV/Aids Reports] |
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| Six months after announcing the $5 billion Project NextGen to develop treatments and vaccines that can “stay ahead of COVID-19,” the US government has awarded 20 contracts that reveal what much of that sum will support.
[Science] |
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| Molnupiravir, an antiviral drug used to treat COVID-19, induces numerous mutations in the SARS-CoV-2 genome that can increase the rate at which the virus evolves — yielding viral variants that might survive and be passed on.
[Nature] |
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| November 28 – 30, 2023
San Francisco, California, United States |
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| | University of Minnesota Twin Cities – Minneapolis, Minnesota, United States |
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| | Karolinska Institutet – Solna, Sweden |
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| | King’s College London – Harrow, England, United Kingdom |
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| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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| | University of Washington – Medical Lake, Washington, United States |
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