Immunology of Infectious Disease News Volume 11.44 | Nov 08 2023

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    Jamie Kang
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    2023-11-08 | IIDN 11.44


    Immunology of Infectious Disease News by STEMCELL Technologies
    Vol. 11.44 – 8 November, 2023
    TOP STORY

    Latent Human Herpesvirus 6 Is Reactivated in CAR T Cells

    Through petabase-scale viral genomics mining, scientists examined the landscape of human latent viral reactivation and demonstrate that HHV-6B can become reactivated in cultures of human CD4+ T cells.
    [Nature]

    Full Article
    Quantify Cytokines with Confidence with High-Performance ELISA Kits
    PUBLICATIONSRanked by the impact factor of the journal

    SARS-CoV-2 Viral Persistence in Lung Alveolar Macrophages Is Controlled by IFN-γ and NK Cells

    Investigators used a model of viral infection in macaques to address whether SARS-CoV-2 persistsed in the body and which mechanisms regulated its persistence.
    [Nature Immunology]

    Full Article

    Respiratory Mucosal Immune Memory to SARS-CoV-2 after Infection and Vaccination

    Researchers showed using bronchoalveolar lavage samples that donors with a history of both infection and vaccination had more airway mucosal SARS-CoV-2 antibodies and memory B cells than those only vaccinated.
    [Nature Communications]

    Full Article

    SARS-CoV-2 Infection Engenders Heterogeneous Ribonucleoprotein Interactions to Impede Translation Elongation in the Lungs

    Researchers exploited tissue-optimized ribosome profiling and severe-COVID-19 model mice to establish the first temporal translation profiles of virus and host genes in the lungs during SARS-CoV-2 pathogenesis.
    [Experimental & Molecular Medicine]

    Full Article

    Dimeric Transmembrane Structure of the SARS-CoV-2 E Protein

    The transmembrane structure of the SARS-CoV-2 E protein was characterized by oriented sample and magic angle spinning solid-state NMR in lipid bilayers and refined by molecular dynamics simulations.
    [Communications Biology]

    Full Article

    Immune Responses and Clinical Outcomes after COVID-19 Vaccination in Patients with Liver Disease and in Liver Transplant Recipients

    After three COVID-19 vaccines, patients with liver disease generally developed robust antibody and T cell responses to vaccination and had mild COVID-19.
    [Journal Of Hepatology]

    Full ArticleGraphical Abstract

    Glycoengineered Keratinocyte Library Reveals Essential Functions of Specific Glycans for All Stages of HSV-1 Infection

    Researchers generated a glycoengineered keratinocyte library delineating human glycosylation pathways to uncover roles of specific glycans at different stages of herpes simplex virus type 1 infectious cycle.
    [Nature Communications]

    Full Article

    Aotus nancymaae Model Predicts Human Immune Response to the Placental Malaria Vaccine Candidate VAR2CSA

    Investigators immunized Aotus nancymaae monkeys with three placental malaria vaccine candidates adjuvanted with Alhydrogel and exploited the model to investigate boosting of functional vaccine responses during placental malaria episodes as well as with nanoparticle antigens.
    [labanimal]

    Full Article

    The Role of an Amphiphilic Helix and Transmembrane Region in the Efficient Acylation of the M2 Protein from Influenza Virus

    The M2 protein of the influenza virus, which is acylated at a membrane-near amphiphilic helix, served as a model for studying the intricate signals governing acylation and its interaction with the cognate enzyme, DHHC20, was investigated using both experimental and computational assays.
    [Scientific Reports]

    Full Article
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    REVIEWS

    Immune Imprinting and Next-Generation Coronavirus Vaccines

    Scientists critically examine the evidence for and against immune imprinting in host humoral responses to SARS-CoV-2 and its implications for COVID-19 booster vaccine programs.
    [Nature Biotechnology]

    Abstract

    The Innate Immune Factor RPRD2/REAF and Its Role in the Lv2 Restriction of HIV

    The authors examine lentiviral restriction 2 restriction and the antiviral role of regulation of nuclear pre-mRNA domain containing 2 (RPRD2) and consider potential mechanisms of action.
    [mBio]

    Full Article
    INDUSTRY AND POLICY NEWS

    SARS-CoV-2 Exploits Innate Miscommunication for Persistence

    Determining the immune crosstalk between macrophages and NK cells in bronchioalveolar lavage fluid during SARS-CoV-2 infection in macaques identifies immunoregulatory properties of NK cells and their implications for viral persistence.
    [Nature Immunology]

    Press Release

    Bavarian Nordic’s Mpox Vaccine Receives Recommendation from US CDC Advisory Committee for Routine Use in Adults at Risk

    Bavarian Nordic announced that the US Centers for Disease Control (CDC) and Prevention’s Advisory Committee on Immunization Practices has voted in favor of recommending the routine use of JYNNEOS®, the company’s FDA-approved mpox vaccine, in adults at risk of mpox infection.
    [Bavarian Nordic]

    Press Release
    FEATURED EVENT

    9th International Conference on Infectious Disease Dynamics

    November 28 – December 1, 2023
    Bologna, Italy

    > See All Events

    JOB OPPORTUNITIES

    Research Assistant – Infectious Diseases

    National University of Singapore – Singapore, Singapore

    Research Assistant – HIV Research

    Rutgers University – New Brunswick, New Jersey, United States

    Lab Coordinator – Infectious Disease

    University of Minnesota Twin Cities – Minneapolis, Minnesota, United States

    Research Associate – Department of Infectious Diseases

    King’s College London – London, England, United Kingdom

    Assistant Professor – Immunology

    Harvard Medical School – Boston, Massachusetts, United States

    > See All Jobs

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