 | | Vol. 11.47 – 29 November, 2023 |
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| Scientists investigated the impact of amino acid substitutions in variants of concern and on force-stability and bond kinetic of the receptor-binding domain–ACE2 interface at a single-molecule resolution.
[Nature Nanotechnology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors investigated how B cells respond to repeated SARS-CoV-2 antigen exposure by Wu01 booster vaccination and Omicron breakthrough infection by performing a molecular longitudinal analysis of the memory B cell pool.
[Science Immunology] |
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| Researchers found that direct infection of resting CD4+ T cells was correlated with the availability of susceptible target cells in lymphoid tissues largely restricted to resting CD4+ T cells in which expression of pTEFb enabled productive infection.
[Journal Of Clinical Investigation] |
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| Investigators identified compounds that showed potent inhibition of host proteases and determined their complex structures with their respective targets. Furthermore, they showed that applying inhibitors simultaneously that blocked both entry pathways had a synergistic antiviral effect.
[Nature Communications] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Scientists induced a pan-H1N1 antibody response in pigs by sequential vaccination with antigenically divergent H1N1 strains.
[Nature Communications] |
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| Investigators examined HIV-1 integrated DNA or transcribed RNA, intracellular p24 protein, and T cell activation markers in CD4+ T cells including in vitro HIV-1-infected cells, reactivated patient-derived cells, and in HIV-1-infected humanized mice, under NMN treatment.
[eBioMedicine] |
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| Multiple linear epitopes from the conserved stem domain of hemagglutinin and the ectodomain of matrix protein 2 were combined with the Helicobacter pylori ferritin, a stable self-assembled nanoplatform, to develop an influenza multiepitope nanovaccine, named MHF.
[Advanced Healthcare Materials] |
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| Researchers developed an innovative conjugate vaccine regimen that used a modified vaccinia virus Ankara co-expressing HIV-1 envelope and the hepatitis B virus surface antigen as a prime, followed by two envelope–hepatitis B virus surface antigen conjugate protein boosts.
[NPJ Vaccines] |
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| Synthesized compounds were tested for their potential inhibition of SARS-CoV-2 pseudovirus in BHK-21-hACE2 cells and H1N1 virus in MDCK cell culture.
[Journal Of Antibiotics] |
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| The authors discuss options for new chronic hepatitis B therapies that could address one or more of the barriers to functional cure, with particular emphasis on the potential role of immunotherapy.
[Expert Review Of Gastroenterology & Hepatology] |
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| Dr. Laura Gibson at UMass Chan Medical School, was among the first to be honored with a Central Mass Champions of Health Care Award from the Worcester Business Journal (WBJ). The award honors those in health care “who are excelling in helping others, promoting innovation or improving access to care”.
[UMass Chan Medical School] |
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| The World Health Organization and Chinese health officials convened via a conference call as the global health agency sought information about reports of increases in respiratory illnesses among children in China that have put disease watchers elsewhere on alert.
[Stat] |
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| January 16 – 19, 2024
San Diego, California, United States & Virtual |
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| | Washington University in St. Louis – Saint Louis, Missouri, United States |
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| | Rutgers Health – Newark, New Jersey, United States |
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| | Animal & Plant Health Agency – Addlestone, England, United Kingdom |
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| | Rutgers Health – Newark, New Jersey, United States |
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| | NIH National Cancer Institute – Bethesda, Maryland, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
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Neural Cell News
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Pancreatic Cell News
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