 | | Vol.11.48 – 6 December, 2023 |
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| To investigate the kinetics of spike-reactive T cells (TS) from SARS-CoV-2 infection, scientists identified the T cell receptor (TCR) sequences of thousands of index TS cells and tracked their frequency in bulk TCRβ repertoires sampled longitudinally from the peripheral blood of persons who had recovered from COVID-19.
[Nature Immunology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers evaluated the cellular immune responses after both SARS-CoV-2 infection and vaccination in patients receiving the anti-CD20 therapy rituximab and those with low B cell counts due to common variable immune deficiency disease.
[Science Translational Medicine] |
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| Investigators identified a human monoclonal antibody, 8-9D, with broad neutralizing potency against SARS-CoV-2 variants. The neutralization mechanism of this antibody was explained by the structural characteristics of 8-9D Fabs in complex with the Omicron BA.5 spike.
[Nature Communications] |
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| Scientists investigated the immunogenicity and efficacy of a prime-boost immunization regimen administered intranasally, intramuscularly, or combinations of the two.
[Scientific Reports] |
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| Researchers investigated the direct effects of spike receptor-binding domain on human cardiomyocytes differentiated from induced pluripotent stem cells.
[Scientific Reports] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Scientists isolated ER membranes from Zika virus-infected cells and determined their proteome. 46 host cell factors were enriched in Zika virus-remodeled membranes, several of these having a role in redox and methylation pathways.
[Nature Communications] |
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| ICR mice were pretreated with human umbilical cord (hUC) MSCs and then infected with the influenza H7N9 virus. Weight, survival days, and lung index of mice were recorded.
[Biochimica Et Biophysica Acta-Molecular Basis Of Disease] |
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| Researchers demonstrated that CD2 expression on CX3CR1+CD57+CD28− inflammescent CD8 T cells was increased on cells from cytomegalovirus-seropositive people with HIV. In vitro CD2/LFA-3 costimulation enhanced TCR-mediated activation of these inflammatory CD8 memory T cells.
[Journal Of Immunology] |
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| Investigators described the humoral and cell-mediated immune responses in 38 cancer patients treated with immune checkpoint inhibitors and receiving the glycoprotein E-based recombinant vaccine.
[Human Vaccines & Immunotherapeutics] |
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| The authors put special emphasis on discussing the methodological difficulties of viral detection in central nervous system (CNS) tissue and discuss immune-based effects contributing to COVID-19-related CNS affection.
[Nature Reviews Neuroscience] |
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| Scientists discuss the design of nanovaccines, including lipid-nanocarrier-based messenger RNA nanovaccines, highlighting engineering strategies for different administration routes, including nasal administration.
[Nature Reviews Bioengineering] |
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| Researchers reported a new mRNA vaccine that induced a tailored immune response in the livers of mice via the activation of liver-specific tissue-resident memory T cells, which control early stages of infection and prevent illness.
[The Scientist] |
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| The WHO report and a study explored a worrisome possibility: that the strain of virus in the Democratic Republic of the Congo, far deadlier than the one that drove the global outbreak, is in some cases spreading between sexual partners.
[Science] |
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| January 17 – 19, 2024
Chiba, Japan |
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| | University of Washington – Medical lake, Washington, United States |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | National University of Singapore – Singapore, Singapore |
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| | Westlake University – Zhejiang, China |
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| | Washington University in St. Louis – Saint Louis, Missouri, United States |
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