 | | Vol. 12.00 – 10 January, 2024 |
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| Investigators constructed dual-drug-combined nanocarriers conjugated with an anti-hACE2 antibody and employed red blood cell (RBC)-hitchhiking, termed “Nanoengineered RBCs,” for targeting lung cells.
[Advanced Materials] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers performed a genome-wide CRISPR dropout screen and integrate analyses of the multi-omics data of the CRISPR screen, genome-wide association studies, single-cell RNA-Seq, and host-virus proteins or protein/RNA interactome.
[Nature Communications] |
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| Scientists compared the ancestral SARS-CoV-2 Lineage A with the more transmissible Delta Variant of Concern. Airborne transmission was evaluated using SARS-CoV-2 infected donor animals at 24 hour post inoculation.
[npj Viruses] |
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| Researchers used an established SARS-like murine model in which responses to primary and/or secondary challenges with murine hepatitis virus type 1 (MHV-1) were analyzed.
[Journal Of Immunology] |
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| Investigators found a cytokine signature in patients receiving vedolizumab who were seropositive compared with seronegative for SARS-CoV-2 antibodies that may be linked to repeated SARS-CoV-2 infections.
[Scientific Reports] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Investigators revealed that placenta-expressed transcript 1 (Plet1) was released from alveolar macrophages, and acted as important mediator of macrophage-epithelial cross-talk during lung repair by inducing proliferation of alveolar epithelial cells and re-sealing of the epithelial barrier.
[Nature Communications] |
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| Investigators described the development of a new technological platform to elucidate the immune function differences in individuals with tuberculosis, integrating single-cell RNA sequencing and cell surface antibody sequencing to provide both genomic and phenotypic information from the same samples.
[Advanced Science] |
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| C57BL/6 mice were infected with influenza A/PR/8/34 as a model for severe viral lung infection and allowed to recover for 21 days. Mice were treated with rapamycin, a well-characterized mammalian target of rapamycin complex 1 inhibitor, on days 12 to 20 after infection, a time period after viral clearance.
[The American Journal Of Pathology] |
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| Scientists evaluated the protective efficacy of polyclonal avian antibodies raised against inactivated whole cells of the PAO1 strain in murine models of acute pneumonia and burn wound. The efficacy of generated antibodies was evaluated against different Pseudomonas aeruginosa strains.
[Scientific Reports] |
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| Scientists summarize the current literature describing the multistep progression from oral human papillomavirus (HPV) infection, persistence, and tumor development in the oropharynx.
[Oncogene] |
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| Researchers hope some of the first rigorous placebo-controlled clinical trials of possible Long Covid treatments will report outcomes, though they may be preliminary.
[Science] |
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| February 11 – 16, 2023
Barga, Italy |
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| | Washington University – Saint Louis, Missouri, United States |
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| | Guangzhou Institutes of Biomedicine and Health – Guangzhou, China |
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| | Emory University – Atlanta, Georgia, United States |
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| | Charité – Universitätsmedizin Berlin – Berlin, Germany |
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| | Virginia Tech – Blacksburg, Virginia, United States |
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