 | | Vol. 12.03 – 24 January, 2024 |
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| Scientists used ‘omic” assays and serology to deeply characterize the global and SARS-CoV-2-specific immunity in the blood of individuals with clear long COVID and non-long COVID clinical trajectories, 8 months post-infection.
[Nature Immunology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers examined the relationship between maternal COVID-19 vaccination and neonatal respiratory distress using a longitudinal cohort of mother-infant pairs in Los Angeles, CA.
[Nature Communications] |
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| Investigators developed lipid nanoparticles to provide safe and effective delivery of plasmid DNA and showed protection against variants of concerns in female small animal models.
[Nature Communications] |
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| Scientists investigated whether nirmatrelvir crossed the blood-placenta barrier to reach the conceptus during pregnancy and the blood–brain barrier in male rats.
[npj Viruses] |
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| Researchers investigated the conformational dynamics and stabilizing features using orthogonal SPR, SEC, nanoDSF, and HDX-MS techniques to better understand how this antigen elicits superior broad neutralizing antibodies as a variant booster vaccine.
[Scientific Reports] |
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| MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
| | Using an immunopeptidomics approach, naturally presented influenza A virus-derived ligands restricted to HLA-A*24:02, HLA-A*68:01, HLA-B*07:02, and HLA-B*51:01 molecules were identified.
[Emerging Microbes & Infections] |
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| Investigators hypothesized that Torque Teno Virus load could be an additional marker for immune function in people living with HIV.
[Journal Of Infectious Diseases] |
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| Researchers showed that IL-1β production was detrimental during Salmonella infection. Mice lacking IL-1β failed to recruit neutrophils to the gut during infection, which reduced tissue damage and prevented depletion of short-chain fatty acid-producing commensals.
[PLOS Biology] |
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| Scientists investigated the susceptibility and permissiveness of human primary immune cells for different Enterovirus D68 (EV-D68) isolates. In human peripheral blood mononuclear cells inoculated with EV-D68, only B cells were susceptible but virus replication was limited.
[mSphere] |
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| The authors discuss concerns, specifically how cell tropism and tissue distribution of mRNA and lipid nanoparticles can lead to toxicity, and their possible reactogenicity.
[Nature Reviews Drug Discovery] |
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| The laureate discusses the groundbreaking work that led to COVID-19 vaccines, why he persisted with RNA research despite repeated setbacks, and the value of scientists working in-person.
[AAMC] |
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| Researchers from Duke-NUS Medical School have discovered a new vaccine candidate that can be delivered through the nose in the form of a spray that promises better and longer-lasting immunity against COVID-19 compared to the conventional COVID-19 vaccine administered subcutaneously.
[NUS News] |
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| February 14 – 18, 2024
Cancun, Mexico |
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| | CSIRO – Canberra, Australia |
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| | Instituto Aragonés de Ciencias de la Salud – Zaragoza, Spain |
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| | Uppsala University – Uppsala, Sweden |
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| | University of Birmingham – Birmingham, England, United Kingdom |
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| | Washington University – Saint Louis, Missouri, United States |
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