 | | Vol. 12.04 – 31 January, 2024 |
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| Scientists examined the virological characteristics of the BA.2.86 variant. Their epidemic dynamics modeling suggested that the relative reproduction number of BA.2.86 was significantly higher than that of EG.5.1.
[Cell Host & Microbe] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators identified a highly conserved neutralizing epitope targeted by a broad-spectrum neutralizing antibody BA7535, which demonstrated high neutralization potency against previous variants, such as Alpha, Beta, Gamma, Delta, and Omicron BA.1-BA.5, and more recently emerged Omicron subvariants.
[Nature Communications] |
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| Researchers performed a prospective analysis of the Vax-On-Third-Profile study to investigate the incidence of HZ after the third dose of mRNA-BNT162b2 and its correlation with immune responses.
[Clinical And Experimental Medicine] |
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| Scientists investigated patterns of retesting in association with initial cycle threshold (Ct)-values. They performed a retrospective analysis of RT-PCR results for patients from whom ≥ 2 samples were collected within 14 days, the first of which had to be positive.
[Scientific Reports] |
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| ChulaCov19 mRNA vaccine demonstrated promising Phase I results. Healthy adults aged 18–59 years were double-blind randomized 4:1 to receive two intramuscular doses of ChulaCov19 50 µg or placebo.
[Scientific Reports] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Scientists developed a dual-color exosome labeling strategy that simultaneously labels the external and internal structures of exosomes with quantum dots. Their finding revealed that vExos contains the complete influenza A virus genome and viral ribonucleoprotein complexes proteins but lacks viral envelope proteins.
[ACS Nano] |
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| Researchers investigated the role of Bhlhe40 in protective T cell responses to the intracellular bacterium Chlamydia in the female reproductive tract.
[PLOS Pathogens] |
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| In several preclinical mouse models of cancer, including melanoma and colorectal cancer, investigators observed that influenza A virus infection in the lung significantly decreased the tumor burden.
[PLOS Pathogens] |
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| Immune indicators involved in innate, humoral, and cellular immune cells, as well as antigen-specific cells were simultaneously assessed in patients with active tuberculosis and latent tuberculosis infection.
[International Immunopharmacology] |
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| The authors consolidate the scientific body of literature on the diagnosis and management of Pneumocystis jirovecii pneumonia in people with HIV, as well as identify areas in need of more study and thoughtfully designed clinical trials.
[Clinical Microbiology Reviews] |
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| On 19 January, the UK Health and Security Agency, the public-health authority, declared a national incident over rising cases of measles. The agency has logged more than 200 cases since 1 October 2023.
[Nature] |
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| Longeveron Inc. announced it received a notice of patent allowance from the United States Patent and Trademark Office for Medicinal Signaling Cells. The allowance impacts patients with Aging-related Frailty receiving vaccines for conditions such as COVID and the flu.
[Longeveron Inc] |
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| February 14 – 16, 2024
Lorne, Australia |
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| | King’s College London – London, England, United Kingdom |
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| | Imperial College London – London, England, United Kingdom |
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| | CSIRO – Canberra, Australia |
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| | Instituto Aragon̩s de Ciencias de la Salud РZaragoza, Spain |
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| | Uppsala University – Uppsala, Sweden |
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