Immunology of Infectious Disease News Volume 12.04 | Feb 07 2024

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    2024-02-07 | IIDN 12.05


    Immunology of Infectious Disease News by STEMCELL Technologies
    Vol. 12.05 – 7 February, 2024
    TOP STORY

    Potent and Broadly Neutralizing Antibodies Against Sarbecoviruses Induced by Sequential COVID-19 Vaccination

    Researchers identified both potent and broadly neutralizing antibodies from a five-dose vaccinated donor who exhibited cross-reactive serum-neutralizing activity against diverse coronaviruses.
    [Cell Discovery]

    Full Article
    Explore Antibodies for Immunology Research
    PUBLICATIONSRanked by the impact factor of the journal

    Identification of Hammerhead-Variant Ribozyme Sequences in SARS-CoV-2

    Scientists reported the identification of 39 Hammerhead-variant ribozyme sequences in SARS-CoV-2. These sequences are highly conserved within SARS-CoV-2 variants but showed large diversity among other coronaviruses.
    [Nucleic Acids Research]

    Full Article

    A Monoclonal Antibody Targeting a Large Surface of the Receptor Binding Motif Shows Pan-Neutralizing SARS-CoV-2 Activity

    Researchers reported the characterization of 17T2, a SARS-CoV-2 pan-neutralizing human monoclonal antibody isolated from a COVID-19 convalescent individual infected during the first pandemic wave.
    [Nature Communications]

    Full Article

    Engineered Wnt7a Ligands Rescue Blood–Brain Barrier and Cognitive Deficits in a COVID-19 Mouse Model

    Investigators identified the underlying mechanisms mediating cerebrovascular dysfunction and inflammation following mild respiratory SARS-CoV-2 infection.
    [Brain]

    Abstract

    SARS-CoV-2 Vaccination May Mitigate Dysregulation of IL-1/IL-18 and Gastrointestinal Symptoms of the Post-COVID-19 Condition

    Scientists analyzed the plasma levels of 25 cytokines and SARS-CoV-2 directed antibodies in 540 individuals with or without post-COVID-19 conditions relative to one or two mRNA-based COVID-19 vaccinations as well as in 20 uninfected individuals one month after their initial mRNA-based COVID-19 vaccination.
    [NPJ Vaccines]

    Full Article

    A Non-Human Primate Model for Human Norovirus Infection

    Researchers established rhesus macaques as an animal model for human norovirus infection. They showed that rhesus macaques are susceptible to oral infection with human noroviruses from two different genogroups.
    [Nature Microbiology]

    Abstract

    Bystander Activated CD8+ T Cells Mediate Neuropathology During Viral Infection via Antigen-Independent Cytotoxicity

    Using a mouse model of Zika virus infection, scientists found that the severity of neurological disease did not correlate with brain Zika virus titers, but rather with infiltration of bystander-activated NKG2D+CD8+ T cells.
    [Nature Communications]

    Full Article

    The Host RNA Polymerase II C-Terminal Domain Is the Anchor for Replication of the Influenza Virus Genome

    Investigators provided evidence that the FluPol-RNAP II binding interface, beyond its well-acknowledged function in cap-snatching during transcription initiation, had also a pivotal role in replication of the viral genome.
    [Nature Communications]

    Full Article

    Epigenetic and Transcriptional Regulation of Cytokine Production by Plasmodium falciparum-Exposed Monocytes

    Scientists provided molecular evidence that histone 3 lysine 4 methylation was key for inflammatory cytokine production in P. falciparum-exposed monocytes.
    [Scientific Reports]

    Full Article
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    REVIEWS

    Organoids in Virology

    The authors highlight key insights that have been contributed by organoid models to virus research, the limitations that exist in current platforms, and outline novel approaches that are being applied to address these shortcomings.
    [npj Viruses]

    Full Article
    INDUSTRY AND POLICY NEWS

    Serious Bacterial Infections Causing Pneumonia, Meningitis on the Rise in Alberta

    Experts are watching closely as cases of invasive pneumococcal disease rise in Alberta. The potentially life-threatening illness is caused by bacteria known as Streptococcus pneumoniae, which often strike after viral illnesses.
    [CBC]

    Press Release
    FEATURED EVENT

    Nanomaterials in Biomedical Applications

    February 26 – 27, 2024
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    JOB OPPORTUNITIES

    Postdoctoral Fellowship – Infectious diseases

    National Research Council Canada – Ottawa West, Ontario, Canada

    Research Assistant – GI Medical Oncology Research Program

    University of Washington – Seattle, Washington, United States

    PhD Fellow – Viral Hepatitis and Disease Modelling

    University of Antwerp – Antwerp, Belgium

    Research Associate – Infectious Diseases

    King’s College London – London, England, United Kingdom

    Research Associate – Microbiomics and Metabonomics

    Imperial College London – London, England, United Kingdom

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