| Vol. 12.05 – 7 February, 2024 |
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| Researchers identified both potent and broadly neutralizing antibodies from a five-dose vaccinated donor who exhibited cross-reactive serum-neutralizing activity against diverse coronaviruses. [Cell Discovery] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists reported the identification of 39 Hammerhead-variant ribozyme sequences in SARS-CoV-2. These sequences are highly conserved within SARS-CoV-2 variants but showed large diversity among other coronaviruses. [Nucleic Acids Research] |
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| Researchers reported the characterization of 17T2, a SARS-CoV-2 pan-neutralizing human monoclonal antibody isolated from a COVID-19 convalescent individual infected during the first pandemic wave. [Nature Communications] |
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| Investigators identified the underlying mechanisms mediating cerebrovascular dysfunction and inflammation following mild respiratory SARS-CoV-2 infection. [Brain] |
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| Scientists analyzed the plasma levels of 25 cytokines and SARS-CoV-2 directed antibodies in 540 individuals with or without post-COVID-19 conditions relative to one or two mRNA-based COVID-19 vaccinations as well as in 20 uninfected individuals one month after their initial mRNA-based COVID-19 vaccination. [NPJ Vaccines] |
| MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Researchers established rhesus macaques as an animal model for human norovirus infection. They showed that rhesus macaques are susceptible to oral infection with human noroviruses from two different genogroups. [Nature Microbiology] |
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| Using a mouse model of Zika virus infection, scientists found that the severity of neurological disease did not correlate with brain Zika virus titers, but rather with infiltration of bystander-activated NKG2D+CD8+ T cells. [Nature Communications] |
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| Investigators provided evidence that the FluPol-RNAP II binding interface, beyond its well-acknowledged function in cap-snatching during transcription initiation, had also a pivotal role in replication of the viral genome. [Nature Communications] |
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| Scientists provided molecular evidence that histone 3 lysine 4 methylation was key for inflammatory cytokine production in P. falciparum-exposed monocytes. [Scientific Reports] |
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| The authors highlight key insights that have been contributed by organoid models to virus research, the limitations that exist in current platforms, and outline novel approaches that are being applied to address these shortcomings. [npj Viruses] |
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| Experts are watching closely as cases of invasive pneumococcal disease rise in Alberta. The potentially life-threatening illness is caused by bacteria known as Streptococcus pneumoniae, which often strike after viral illnesses. [CBC] |
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| February 26 – 27, 2024 Manipal, India |
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| National Research Council Canada – Ottawa West, Ontario, Canada |
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| University of Washington – Seattle, Washington, United States |
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| University of Antwerp – Antwerp, Belgium |
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| King’s College London – London, England, United Kingdom |
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| Imperial College London – London, England, United Kingdom |
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