Immunology of Infectious Disease News Volume 12.07 | Feb 21 2024

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    2024-02-21 | IIDN 12.07


    Immunology of Infectious Disease News by STEMCELL Technologies
    Vol. 12.07 – 21 February, 2024
    TOP STORY

    Asialoglycoprotein Receptor 1 Promotes SARS-CoV-2 Infection of Human Normal Hepatocytes

    Scientists performed a genome-wide CRISPR-Cas9 activation library screening and found that Asialoglycoprotein receptor 1 promoted SARS-CoV-2 pseudovirus infection of HeLa cells.
    [Signal Transduction And Targeted Therapy]

    Full Article
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    SARS-CoV-2 Spike Protein-ACE2 Interaction Increases Carbohydrate Sulfotransferases and Reduces N-Acetylgalactosamine-4-Sulfatase by p38 MAPK

    Human small airway epithelial cells were exposed to the SARS-CoV-2 spike protein receptor binding domain and transcriptional mechanisms were investigated.
    [Signal Transduction And Targeted Therapy]

    Full Article

    Mucosal and Systemic Immune Correlates of Viral Control after SARS-CoV-2 Infection Challenge in Seronegative Adults

    Researchers performed intranasal inoculation of 34 young adult, seronegative volunteers with a pre-Alpha SARS-CoV-2 strain.
    [Science Immunology]

    Abstract

    The Role of SARS-CoV-2 ORF7a in Autophagy Flux Disruption: Implications for Viral Infection and Pathogenesis

    Researchers highlighted that open reading frame 7a (ORF7a) could be a therapeutic target, and glecaprevir may hold potential as a drug against SARS-CoV-2 by targeting ORF7a.
    [Autophagy]

    Abstract

    HIV, HIV-Specific Factors, and Myocardial Disease in Women

    Scientists investigated the associations of HIV and HIV-specific factors with cardiac magnetic resonance phenotypes in female participants enrolled in the Women’s Interagency HIV Study’s New York and San Francisco sites.
    [Clinical Infectious Diseases]

    Abstract

    A TNF-IL-1 Circuit Controls Yersinia within Intestinal Pyogranulomas

    Investigators demonstrated that tumor necrosis factor signaling in monocytes is required for bacterial containment following enteric Yersinia infection.
    [Journal Of Experimental Medicine]

    Abstract

    The Effects of Human Immunodeficiency Virus Type 1 (HIV-1) Antigen-Expanded Specific T-Cell Therapy and Vorinostat on Persistent HIV-1 Infection in People with HIV on Antiretroviral Therapy

    Six people with HIV (PWH) received infusions of 2 × 107 HIV-specific T cells (HXTCs)/m² with vorinostat (VOR) 400 mg, and 3 PWH received infusions of 10 × 107 HXTCs/m² with VOR. The frequency of persistent HIV by multiple assays was measured before and after study therapy.
    [Journal Of Infectious Diseases]

    Abstract

    Exploring the Immunogenicity of Rv2201-519: A T-Cell Epitope-Based Antigen Derived from Mycobacterium tuberculosis AsnB with Implications for Tuberculosis Infection Detection and Vaccine Development

    Investigators constructed a T-cell epitope-rich tripeptide-splicing fragment of Rv2201 from the Mycobacterium tuberculosis genome, ultimately yielding the recombinant protein Rv2201-519 in Escherichia coli BL21.
    [International Immunopharmacology]

    Abstract

    Higher CCR5 Density on CD4+ T Cells in Mothers and Infants Is Associated with Increased Risk of In-Utero HIV-1 Transmission

    Researchers provided strong evidence of a protective role for a combined mother–infant low CD4+ T-cell CCR5 density phenotype in in-utero transmission/acquisition of HIV-1.
    [Aids]

    Abstract
    How to prioritize and manage your research projects
    REVIEWS

    Fighting Flu: Novel CD8+ T Cell Targets are Required for Future Influenza Vaccines

    The authors summarize many of the currently licensed influenza vaccines available across the world and current vaccines in clinical trials. They then briefly discuss the important role of CD8+ T cells during influenza infection and why future influenza vaccines should consider targeting CD8+ T cells.
    [Clinical & Translational Immunology]

    Full Article
    INDUSTRY AND POLICY NEWS

    COVID’s Preprint Bump Set to Have Lasting Effect on Research Publishing

    The COVID-19 pandemic saw an explosion in publication of preprint articles, many by authors who had never produced one before. Now it seems a high proportion of these scientists are likely to continue the practice.
    [Nature]

    Full Article
    FEATURED EVENT

    18th World Immune Regulation Meeting

    March 13 – 16, 2024
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    JOB OPPORTUNITIES

    Research Associate – Infectious Diseases

    King’s College London – London, England, United Kingdom

    Research Assistant – Microbial Biochemistry and Pathogenesis

    Queen’s University Belfast – Belfast, Ireland, United Kingdom

    Research Associate – Malarial Damage in the Placenta

    University of Alberta – Edmonton, Alberta, Canada

    Department Chair – Cell Biology and Human Anatomy

    UC Davis – Davis, California, United States

    Postdoctoral Position – Bacterial Gene Regulation

    Ume̴ University РUme̴, Sweden

    > See All Jobs

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