| Vol. 12.07 – 21 February, 2024 |
| |
|
|
| Scientists performed a genome-wide CRISPR-Cas9 activation library screening and found that Asialoglycoprotein receptor 1 promoted SARS-CoV-2 pseudovirus infection of HeLa cells. [Signal Transduction And Targeted Therapy] |
|
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
| |
|
|
| Human small airway epithelial cells were exposed to the SARS-CoV-2 spike protein receptor binding domain and transcriptional mechanisms were investigated. [Signal Transduction And Targeted Therapy] |
|
|
|
| Researchers performed intranasal inoculation of 34 young adult, seronegative volunteers with a pre-Alpha SARS-CoV-2 strain. [Science Immunology] |
|
|
|
| Researchers highlighted that open reading frame 7a (ORF7a) could be a therapeutic target, and glecaprevir may hold potential as a drug against SARS-CoV-2 by targeting ORF7a. [Autophagy] |
| MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
|
|
|
| Scientists investigated the associations of HIV and HIV-specific factors with cardiac magnetic resonance phenotypes in female participants enrolled in the Women’s Interagency HIV Study’s New York and San Francisco sites. [Clinical Infectious Diseases] |
|
|
|
| Investigators demonstrated that tumor necrosis factor signaling in monocytes is required for bacterial containment following enteric Yersinia infection. [Journal Of Experimental Medicine] |
|
|
|
| Six people with HIV (PWH) received infusions of 2 × 107 HIV-specific T cells (HXTCs)/m² with vorinostat (VOR) 400 mg, and 3 PWH received infusions of 10 × 107 HXTCs/m² with VOR. The frequency of persistent HIV by multiple assays was measured before and after study therapy. [Journal Of Infectious Diseases] |
|
|
|
| Investigators constructed a T-cell epitope-rich tripeptide-splicing fragment of Rv2201 from the Mycobacterium tuberculosis genome, ultimately yielding the recombinant protein Rv2201-519 in Escherichia coli BL21. [International Immunopharmacology] |
|
|
|
| Researchers provided strong evidence of a protective role for a combined mother–infant low CD4+ T-cell CCR5 density phenotype in in-utero transmission/acquisition of HIV-1. [Aids] |
|
|
|
|
| The authors summarize many of the currently licensed influenza vaccines available across the world and current vaccines in clinical trials. They then briefly discuss the important role of CD8+ T cells during influenza infection and why future influenza vaccines should consider targeting CD8+ T cells. [Clinical & Translational Immunology] |
|
|
|
|
| The COVID-19 pandemic saw an explosion in publication of preprint articles, many by authors who had never produced one before. Now it seems a high proportion of these scientists are likely to continue the practice. [Nature] |
|
|
|
|
| March 13 – 16, 2024 Davos, Switzerland |
|
|
|
|
|
| King’s College London – London, England, United Kingdom |
|
|
|
| Queen’s University Belfast – Belfast, Ireland, United Kingdom |
|
|
|
| University of Alberta – Edmonton, Alberta, Canada |
|
|
|
| UC Davis – Davis, California, United States |
|
|
|
| UmeÃ¥ University – UmeÃ¥, Sweden |
|
|
|
|