 | | Vol. 12.08 – 28 February, 2024 |
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| Investigators analyzed the kinetics and durability of the humoral responses to SARS-CoV-2 infection and vaccination using >8,000 longitudinal samples collected over a three-year period in New York City.
[Immunity] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers demonstrated that ATG5 deficiency in myeloid cells could significantly inhibit the growth of rodent blood-stage malarial parasites by selectively enhancing parasite-specific CD4+ Th1 cell responses. This effect was independent of ATG5-mediated canonical and non-canonical autophagy.
[Autophagy] |
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| Investigators identified human TfR, one of the most ubiquitously and highly expressed membrane components, as a receptor of SARS-CoV-2. TfR mediated SARS-CoV-2 infection by directly binding to the spike with high affinity and transporting the virus into the host cells.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Researchers prospectively evaluated esophageal muscle for SARS-CoV-2 from patients with rapid-onset achalasia post–COVID-19 and compare them with achalasia predating COVID-19 and achalasia with no COVID-19.
[American Journal Of Gastroenterology] |
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| MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
| | Scientists adapted a biochemical method and analysis pipeline to identify targets of miRNAs in lung cells infected with respiratory syncytial virus.
[Nucleic Acids Research] |
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| Non-hospitalized participants within five days of SARS-CoV-2 symptoms randomised to receive molnupiravir or Usual Care were recruited to study viral and antibody dynamics and the effect of molnupiravir on viral whole genome sequence from 1437 viral genomes.
[Nature Communications] |
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| Researchers assessed the efficacy of lipid nanoparticles-encapsulated mRNA booster vaccines encoding the spike protein of SARS-CoV-2 for variants of concern and using a predecessor strain spike protein to elicit durable cross-protective neutralizing antibody responses.
[NPJ Vaccines] |
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| Scientists reported that Chlamydia trachomatis (CT) infection supported HPV persistence by further suppressing the functions of Langerhans cells (LCs); in particular, CT further activated the PI3K pathway and inhibited the MAPK pathways in LCs.
[BMC Infectious Diseases] |
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| The authors provide an overview of the potential triggers of endothelial activation related to COVID-19 and COVID-19 under diabetic milieu.
[Cardiovascular Diabetology] |
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| A lack of funding and incentives for research into antimicrobial resistance is causing scientists to leave the field, finds a report by the AMR Industry Alliance, an industry body that brings together more than 100 pharmaceutical companies and associations.
[Nature] |
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| City of Hope treated the oldest person to be cured of blood cancer and then achieve remission for HIV after receiving a stem cell transplant from a donor with a rare genetic mutation.
[City of Hope] |
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| April 7 – 10, 2024
San Diego, California, United States |
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| | University of Washington – Medical Lake, Washington, United States |
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| | Queen’s University Belfast – Belfast, Ireland, United Kingdom |
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| | University of Alberta – Edmonton, Alberta, Canada |
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| | UC Davis – Davis, California, United States |
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| | Umeå University – Umeå, Sweden |
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