Immunology of Infectious Disease News Volume 12.09 | Mar 06 2024

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    2024-03-06 | IIDN 12.09


    Immunology of Infectious Disease News by STEMCELL Technologies
    Vol. 12.09 – 6 March, 2024
    TOP STORY

    Outcomes in Hematopoietic Cell Transplant and Chimeric Antigen Receptor T Cell Therapy Recipients with Pre-Cellular Therapy SARS-CoV-2 Infection

    Researchers conducted a retrospective cohort study of patients with SARS-CoV-2 infection within 90 days prior to hematopoietic cell transplant or CAR-T therapy between January 2020 and November 2022.
    [Clinical Infectious Diseases]

    Abstract
    March 2024 Science Events
    PUBLICATIONSRanked by the impact factor of the journal

    Frequency, Kinetics and Determinants of Viable SARS-CoV-2 in Bioaerosols from Ambulatory COVID-19 Patients Infected with the Beta, Delta or Omicron Variants

    Scientists confirmed variant-specific culturable SARS-CoV-2 in aerosol, inform the targeting of transmission-related interventions and public health containment strategies emphasizing improved ventilation.
    [Nature Communications]

    Full Article

    Impacts of Optimal Control Strategies on the HBV and COVID-19 Co-Epidemic Spreading Dynamics

    Researchers was to investigate the optimal impacts of four time-dependent control strategies on the HBV and COVID-19 co-epidemic transmission using a compartmental modeling approach.
    [Scientific Reports]

    Full Article

    Severe COVID-19 and Long COVID Are Associated with High Expression of STING, cGAS and IFN-α

    Investigators evaluated the association of cGAS and STING gene expression levels and plasma IFN-α, TNF-α and IL-6 levels with COVID-19 severity in acute infection and long COVID, based on analysis of blood samples from 148 individuals, 87 with acute COVID-19 and 61 in the post-COVID-19 period.
    [Scientific Reports]

    Full Article

    RNA–RNA Interactions Between Respiratory Syncytial Virus and miR-26 and miR-27 Are Associated with Regulation of Cell Cycle and Antiviral Immunity

    Scientists adapted a biochemical method and analysis pipeline to identify targets of miRNAs in lung cells infected with respiratory syncytial virus.
    [Nucleic Acids Research]

    Full Article
    Graphical Abstract

    Distinctive Antibody Responses to Mycobacterium tuberculosis in Pulmonary and Brain Infection

    Researchers characterized the antibody profiles across the blood and brain compartments during tuberculosis meningitis (TBM), and determined whether Mycobacterium tuberculosis (Mtb)-specific humoral immune responses differed between Mtb infection of the lung and TBM.
    [Brain]

    Abstract

    Stem Cell-Derived CAR T Cells Show Greater Persistence, Trafficking, and Plasma Viral Control Compared to Ex Vivo Transduced CAR T Cells In Vivo

    Using the humanized bone marrow/liver/thymus mouse model and nonhuman primate model of HIV infection, scientists evaluated two CAR-based gene therapy approaches.
    [Molecular Therapy]

    AbstractGraphical Abstract

    Conserved Molecular Chaperone PrsA Stimulates Protective Immunity Against Group A Streptococcus

    Investigators explored the potential of PrsA1 and PrsA2 as vaccine candidates for preventing Group A Streptococcus (GAS) infection. They found that PrsA1 and PrsA2 are highly conserved among GAS isolates, demonstrating minimal amino acid variation.
    [NPJ Vaccines]

    Full Article

    TLR2 on CD4+ and CD8+ T cells promotes control of Mycobacterium tuberculosis infection

    To address TLR2 on T cells, investigators generated Tlr2fl/flxCd4cre/cre mice, which lacked expression of TLR2 on both CD4 and CD8 T cells, to study the in vivo role of TLR2 on T cells after aerosol infection with virulent Mycobacterium tuberculosis.
    [NPJ Vaccines]

    Full Article

    circRNA_SLC8A1 Promotes the Survival of Mycobacterium tuberculosis in Macrophages by Upregulating Expression of Autophagy-Related Protein SQSTM1/p62 to Activate the NF-κB Pathway

    Researchers found that miR-20b-5p expression was decreased, while sequestosome 1 (SQSTM1) protein expression was increased in a time- and dose-dependent manner in the human macrophage U937 in response to Mycobacterium tuberculosis infection.
    [Scientific Reports]

    Full Article
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    REVIEWS

    The Effect of HIV and Mpox Co-Infection on Clinical Outcomes: Systematic Review and Meta-Analysis

    The authors provide insight into the impact of HIV and mpox co-infection on clinical outcomes. These findings highlight the significance of early diagnosis, prompt treatment initiation, and effective management strategies for people living with HIV and mpox.
    [HIV Medicine]

    Abstract
    INDUSTRY AND POLICY NEWS

    Two Very Rare COVID Vaccine Side-Effects Detected in Global Study of 99 Million

    Two new but exceptionally rare COVID-19 vaccine side effects – a neurological disorder and inflammation of the spinal cord – have been detected by researchers in the largest vaccine safety study to date.
    [The Guardian]

    Press Release

    BC Reports First Measles Case Since 2019

    A case of measles has been reported in British Columbia — the first since 2019 — as the number of infections rises in some parts of the world, and provincial health officials are urging residents to make sure they’re up to date on vaccines.
    [CBC]

    Press Release

    NEJM Features Patient Who Achieved HIV, Leukemia Remission

    City of Hope treated the oldest person to be cured of blood cancer and then achieve remission for HIV after receiving a stem cell transplant from a donor with a rare genetic mutation.
    [City of Hope]

    Press Release
    FEATURED EVENT

    Systems and Engineering Immunology: Advancing Immunological Insights in Health and Disease

    April 9 – 12, 2024
    Fairmont Banff Springs, Alberta, Canada

    > See All Events

    JOB OPPORTUNITIES

    Assistant Professor – Infectious Diseases

    Indiana University – Indiana, Pennsylvania, United States

    Clinical Laboratory Technician – Infectious Diseases

    University of Washington – Medical Lake, Washington, United States

    Research Associate – Malarial Damage in the Placenta

    University of Alberta – Edmonton, Alberta, Canada

    Department Chair – Cell Biology and Human Anatomy

    UC Davis – Davis, California, United States

    Postdoctoral Position – Bacterial Gene Regulation

    Ume̴ University РUme̴, Sweden

    > See All Jobs

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