 | | Vol. 12.10 – 13 March, 2024 |
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Researchers developed multiple chimeric antigen receptors based on single-chain variable fragments, respectively, targeting HBV large and small envelope proteins. Their impacts on hepatitis B surface antigen secretion and HBV infection, and the underlying mechanisms, were extensively investigated.
[Gut] |
|  | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using reverse mutagenesis, the authors found that a phenylalanine-to-serine mutation at position 375 in the spike protein of Omicron to revert it to the sequence found in Delta and other ancestral strains significantly enhanced the immunogenicity of Omicron vaccines.
[Nature Immunology] |
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| In the ENSEMBLE randomized, placebo-controlled phase III trial, estimated single-dose Ad26.COV2.S vaccine efficacy was 56% against moderate to severe–critical COVID-19.
[Nature Communications] |
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| Scientists evaluated antibody responses to SARS-CoV-2 spike and nucleocapsid antigens from Wuhan and variants of concern by Luminex and their role in preventing breakthrough infections 1 year after a third dose of mRNA vaccination, in a cohort of health care workers followed since the pandemic onset in Spain.
[BMC Medicine] |
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| Researchers evaluated the immunogenicity and efficacy of different rationally designed lipid and polymeric-based nanoparticle prototypes against SARS-CoV-2 infection.
[NPJ Vaccines] |
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| Scientists modeled the complete tertiary structure of native and mutated forms of the N protein using Alphafold2. Notably, the N protein contained three disordered regions.
[Scientific Reports] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Investigators found that CD38’s extracellular glycohydrolase activity restricts metabolic reprogramming after TCR-engaging stimulation in Jurkat T CD4 cells, together with functional responses, while reducing intracellular NAD and NMN concentrations.
[Journal Of Leukocyte Biology] |
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| Scientists identified PRMT5 as a critical regulator of CD4+ T follicular helper cell (Tfh) responses during influenza virus infection in mice. Conditional PRMT5 deletion in murine T cells results in almost complete ablation of both Tfh and T follicular regulatory populations.
[Journal Of Immunology] |
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| The authors investigated and compared the immune response in clinically defined cohorts of Dengue with and without warning signs, with the aim of identifying immunological correlates of clinical disease and potential markers of disease severity.
[Cytokine] |
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| The myeloid cell compartment represents an important target of HIV-1 infection. While myeloid reservoirs may be more difficult to measure than CD4+ T cell reservoirs, they are long-lived, contribute to viral persistence, and, unless specifically targeted, will prevent an HIV-1 cure.
[Current HIV/Aids Reports] |
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| People with HIV are the latest group to benefit from the new generation of anti-obesity drugs. If early data about the treatments’ effects are confirmed, the drugs could become key to controlling the metabolic problems often caused by anti-HIV medications.
[Nature] |
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| The Chan Zuckerberg Initiative announced a $4 million grant to support research led by the UCLA Samueli School of Engineering that will examine cellular behaviors, many of which play a key role in developing immunity to pathogens and disease.
[UCLA Samueli] |
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| Shima Shahbaz from the Elahi lab, the School of Dentistry at the University of Alberta has emerged as one of the first recipients of the Canadian Institutes of Health Research (CIHR) 2024 Research Excellence, Diversity, and Independence Early Career Transition Award.
[University of Alberta] |
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| April 17 – 20, 2024
Rotterdam, Netherlands |
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| | The University of Iowa – Iowa City, Iowa, United States |
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| | Indiana University – Indiana, Pennsylvania, United States |
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| | University of Washington – Medical Lake, Washington, United States |
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| | UC Davis – Davis, California, United States |
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| | Umeå University – Umeå, Sweden |
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