 | | Vol. 12.13 – 3 April, 2024 |
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| The authors engineered an anti–PD-1 chimeric antigen receptor (CAR) to assess the impact of PD-1 depletion on viral reservoirs and rebound dynamics in SIVmac239–infected rhesus macaques.
[Journal Of Clinical Investigation] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| To improve the antiviral potency of β-D-N4-hydroxycytidine (NHC), the metabolite of a recently approved treatment for COVID-19, researchers developed a panel of NHC conjugates with lipophilic vectors and ester derivatives with amino- and carboxylic-acids.
[Antiviral Research] |
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| Investigators reported that human transmembrane protease serine 2 (TMPRSS2) was a molecular determinant of viral entry for all the Omicron clinical isolates tested in human lung cells, including ancestral Omicron subvariants, contemporary Omicron subvariants and currently circulating Omicron BA.2.86.
[Antiviral Research] |
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| Scientists conducted a comprehensive metabolomic analysis of plasma samples obtained from pregnant women who displayed varying post-vaccination antibody titers after receiving mRNA-1273-SARS-CoV-2 vaccines.
[Journal Of Molecular Medicine] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Scientists demonstrated a protective role for autophagy in HIV-1 disease pathogenesis. Targeted analysis of genetic variation in core autophagy gene ATG16L1 revealed the previously unidentified rs6861 polymorphism, which correlated functionally with enhanced autophagy.
[Nature Communications] |
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| Researchers established a mouse model of co-infection with unrelated viruses, influenza A (IAV) and Semliki Forest virus (SFV), causing disease in different organ systems. SFV infection eight days before IAV infection results in prolonged IAV replication and exacerbated lung pathology.
[Nature Communications] |
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| Persons with HIV on antiretroviral therapy were enrolled in the clinical trial. Blood was collected at baseline and days 2,4,7,14, and 30 postimmunizations. Expression of immunological markers on T cell subsets were measured by flow cytometry.
[Aids] |
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| Researchers found that the presence of viral infection was evidently associated with improved outcomes in cancer patients undergoing immune checkpoint inhibitors, particularly in cases of HBV/HCV and HPV infections.
[Cancer Immunology Immunotherapy] |
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| Scientists used a systems biology approach to compare hematological, biochemical, transcriptomic, and innate and antibody-mediated immune responses in cynomolgus macaques and human participants following YF-17D vaccination.
[Journal Of Virology] |
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| The authors review similar and distinct innate immune manipulation strategies employed by the seven human coronaviruses. They further discuss the impact on pathogenesis, zoonotic emergence, and adaptation.
[Current Opinion In Microbiology] |
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| When Lisa McCorkell got COVID-19 in March 2020, her symptoms were mild, and was told to isolate herself from others and that she would recover in a few weeks. But the weeks stretched into months and McCorkell started having debilitating and bewildering symptoms.
[Nature] |
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| Creutzfeldt-Jakob disease is the most prominent of the handful of diseases, all fatal, that result when prions, proteins of uncertain function that are abundant in the brain, misfold into an infective form that spreads widely.
[Science] |
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| April 23-25, 2024
Boston, Massachusetts, United States |
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| | University of Washington – Medical Lake, Washington, United States |
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| | Johns Hopkins School of Medicine – Saint Petersburg, Florida, United States |
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| | Cellistic – Mont-Saint-Guibert, Belgium |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | University of Colorado – Aurora, Colorado, United States |
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