 | | Vol. 12.14 – 17 April, 2024 |
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| The authors investigated differences in the cellular landscape and function of pediatric, adult, and older adult ex vivo cultured nasal epithelial cells in response to infection with SARS-CoV-2.
[Nature Microbiology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that in this large national cohort comprising two years’ active surveillance over four SARS-CoV-2 variant periods and with near complete follow-up of pregnancy outcomes for 16,627 included women, severe perinatal outcomes were more common in women with moderate to severe COVID-19, during the delta dominant period and among unvaccinated women.
[Nature Communications] |
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| The authors established vascular immune organoids from human pluripotent stem cells and examined the effect of SARS-CoV-2 infection.
[Scientific Reports] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Investigators longitudinally analyzed immune responses in healthy adults after two-dose vaccination with either a virus-like particle COVID-19 vaccine (CoVLP), CoVLP adjuvanted with AS03, or a messenger RNA vaccination.
[Science Immunology] |
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| In a secondary analysis of the SHINE trial in rural Zimbabwe researchers explored biological pathways underlying infant mortality, and maternal factors shaping immune development in HIV-exposed uninfected infants.
[Nature Communications] |
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| Porcine epidemic diarrhea virus mutants containing a complete nsp2 deletion was entirely avirulent in vivo, with significantly increased productions of interferon beta and IFN-stimulated genes in various intestinal tissues of challenged newborn piglets.
[Autophagy] |
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| Investigators demonstrated that Pla2g2e-/- mice had significantly lower survival rates and higher viral loads in lungs compared to wild-type mice following influenza virus infection.
[Journal Of Virology] |
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| To assess the role of route and age at infection in modeling human cytomegalovirus in mice, scientists infected prepubescent and young sexually mature C57BL/6 mice intranasally, a likely physiological route in humans) and intraperitoneally, which was frequently used experimental route, and was possibly akin to transplant-mediated infection.
[Applied And Environmental Microbiology] |
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| Retrospective analysis at a tertiary care center in Canada of preterm infants less than or equal to 34 0/7 weeks’ gestation with umbilical cord blood culture (UCBC) taken at birth. Of 505 admitted infants, 195 had UCBC.
[Pediatric Research] |
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| Myeloid C-type lectin receptors exhibited a remarkable ability to recognize an extensive array of ligands, from carbohydrates and beyond, and encompass pattern-associated molecular patterns, damage-associated molecular patterns, and markers of altered self.
[Immunity] |
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| Understanding the factors and mechanisms of MDSC expansion during HIV infection is central to understanding the pathophysiology of HIV infection.
[Genes And Immunity] |
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| Long COVID has been a vexing foe, but these clinical trials mark a new chapter. They’re the first targeting the syndrome’s underlying biology, including the one Hayden joined, focus on a key question: Is lingering SARS-CoV-2 virus behind patients’ symptoms?
[Science Insider] |
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| Canada will not reach the original World Health Organization’s (WHO) target of eliminating the Hepatitis C virus by 2030 and lags in comparison to other developed countries, a new study led by researchers at the University of Waterloo has found.
[University of Waterloo] |
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| May 21-23, 2024
New York, New York, United States |
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| | Cold Spring Harbor Laboratory – Cold Spring Harbor, New York, United States |
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| | Indiana University School of Medicine – Indianapolis, Indiana, United States |
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| | EPFL – Lausanne, Switzerland |
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| | University of Washington – Medical Lake, Washington, United States |
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| | Johns Hopkins School of Medicine – Saint Petersburg, Florida, United States |
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