Immunology of Infectious Disease News Volume 12.15 | Apr 24 2024

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    2024-04-24 | IIDN 12.14


    Immunology of Infectious Disease News by STEMCELL Technologies
    Vol. 12.15 – 24 April, 2024
    TOP STORY

    Interferon-Induced Transmembrane Protein-1 Competitively Blocks Ephrin Receptor A2-Mediated Epstein–Barr Virus Entry into Epithelial Cells

    Scientists reported that interferon-induced transmembrane protein-1 (IFITM1) inhibited ephrin receptor A2-mediated Epstein–Barr virus (EBV) entry into epithelial cells (ECs). RNA-sequencing and clinical sample analysis showed reduced IFITM1 in EBV-positive ECs.
    [Nature Microbiology]

    Full Article
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    SARS-CoV-2 nsp15 Preferentially Degrades AU-Rich dsRNA via Its dsRNA Nickase Activity

    The authors prepared numerous RNA substrates, including both long substrates mimicking the viral genome and short defined RNA, to clarify the substrate preference and cleavage pattern of SARS-CoV-2 nsp15.
    [Nucleic Acids Research]

    Full ArticleGraphical Abstract

    COVID-19 and Asthma Onset in Children

    This retrospective cohort study examined children ages 1 to 16 within the Children’s Hospital of Philadelphia Care Network who received PCR testing for SARS-CoV-2 between March 1, 2020 and February 28, 2021.
    [Pediatrics]

    Full ArticlePress Release

    A Randomized Clinical Trial Investigating the Impact of Magnesium Supplementation on Clinical and Biochemical Measures in COVID-19 Patients

    Scientists examined the impact of magnesium supplementation on clinical outcomes and biochemical factors among hospitalized patients with COVID-19.
    [Virology Journal]

    Full Article

    Severity of COVID-19 Infection in Patients with COVID-19 Combined with Diabetes

    Investigators analyzed the correlation between blood glucose control and the severity of COVID-19 infection in patients with diabetes.
    [Journal Of Health Population And Nutrition]

    Full Article

    HIV-1–Infected T Cell Clones Are Shared across Cerebrospinal Fluid and Blood during ART

    Researchers profiled people with HIV and uninfected controls through single-cell transcriptomic and T cell receptor sequencing to understand the dynamics of HIV persistence in the central nervous system.
    [JCI Insight]

    Full Article

    In Silico Design of a Novel Multi-Epitope Vaccine Against HCV Infection through Immunoinformatics Approaches

    An immunoinformatics method was applied to design a multi-epitope vaccine against the hepatitis C virus (HCV). The best B- and T-cell epitopes from conserved regions of the E2 protein of seven HCV genotypes were joined with the appropriate linkers to design a multi-epitope vaccine.
    [International Journal Of Biological Macromolecules]

    Abstract

    Ripretinib Inhibits HIV-1 Transcription through Modulation of PI3K-AKT-mTOR

    Researchers performed a high-throughput screening of FDA-approved compound library in the J-Lat A2 cell line. They discovered ripretinib being an latency-promoting agent candidate, which was validated and observed to hinder proviral activation in cell models harboring latent infections.
    [Acta Pharmacologica Sinica]

    Abstract

    Indirect CD4+ T Cell Protection against Mouse Gamma-Herpesvirus Infection via Interferon Gamma

    Scientists showed that the action of IFNγ was indirect, as CD4+ T cell-mediated control of type 1 alveolar epithelial cell infection depended on IFNγ receptor expression in CD11c+ cells.
    [Journal Of Virology]

    Abstract
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    REVIEWS

    The Role and Impact of Viruses on Cancer Development

    Investigators focus on three major aspects of oncoviruses’ role in cancer development. They discuss geographic distribution, revealing that seven oncoviruses cause 20% of all human cancers worldwide.
    [Periodontology 2000]

    Abstract

    Exploring the Association Between Erythema Multiforme and HIV Infection: Some Mechanisms and Implications

    The authors highlight the potential direct and indirect role that HIV infection may play in the development of erythema multiforme and the clinical dilemma that arises in the management of HIV-infected patients with this condition.
    [Aids Research And Therapy]

    Full Article
    INDUSTRY AND POLICY NEWS

    WHO Clarifies What Counts as a Pathogen that Can Spread through the Air

    The World Health Organization is opening up the definition of airborne pathogens – such as Covid-19, influenza and measles – to include when respiratory droplets spread through the air and when they land on a person, regardless of the size of the droplet.
    [CNN Health]

    Press Release
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    JOB OPPORTUNITIES

    Senior Researcher – Pediatric Respiratory Viral Infections

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

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    Cold Spring Harbor Laboratory – Cold Spring Harbor, New York, United States

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    Indiana University School of Medicine – Indianapolis, Indiana, United States

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    University of Washington – Medical Lake, Washington, United States

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