| Vol. 12.15 – 24 April, 2024 |
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| Scientists reported that interferon-induced transmembrane protein-1 (IFITM1) inhibited ephrin receptor A2-mediated Epstein–Barr virus (EBV) entry into epithelial cells (ECs). RNA-sequencing and clinical sample analysis showed reduced IFITM1 in EBV-positive ECs. [Nature Microbiology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors prepared numerous RNA substrates, including both long substrates mimicking the viral genome and short defined RNA, to clarify the substrate preference and cleavage pattern of SARS-CoV-2 nsp15. [Nucleic Acids Research] |
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| This retrospective cohort study examined children ages 1 to 16 within the Children’s Hospital of Philadelphia Care Network who received PCR testing for SARS-CoV-2 between March 1, 2020 and February 28, 2021. [Pediatrics] |
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| Scientists examined the impact of magnesium supplementation on clinical outcomes and biochemical factors among hospitalized patients with COVID-19. [Virology Journal] |
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| Investigators analyzed the correlation between blood glucose control and the severity of COVID-19 infection in patients with diabetes. [Journal Of Health Population And Nutrition] |
| MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Researchers profiled people with HIV and uninfected controls through single-cell transcriptomic and T cell receptor sequencing to understand the dynamics of HIV persistence in the central nervous system. [JCI Insight] |
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| An immunoinformatics method was applied to design a multi-epitope vaccine against the hepatitis C virus (HCV). The best B- and T-cell epitopes from conserved regions of the E2 protein of seven HCV genotypes were joined with the appropriate linkers to design a multi-epitope vaccine. [International Journal Of Biological Macromolecules] |
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| Researchers performed a high-throughput screening of FDA-approved compound library in the J-Lat A2 cell line. They discovered ripretinib being an latency-promoting agent candidate, which was validated and observed to hinder proviral activation in cell models harboring latent infections. [Acta Pharmacologica Sinica] |
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| Scientists showed that the action of IFNγ was indirect, as CD4+ T cell-mediated control of type 1 alveolar epithelial cell infection depended on IFNγ receptor expression in CD11c+ cells. [Journal Of Virology] |
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| Investigators focus on three major aspects of oncoviruses’ role in cancer development. They discuss geographic distribution, revealing that seven oncoviruses cause 20% of all human cancers worldwide. [Periodontology 2000] |
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| The authors highlight the potential direct and indirect role that HIV infection may play in the development of erythema multiforme and the clinical dilemma that arises in the management of HIV-infected patients with this condition. [Aids Research And Therapy] |
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| The World Health Organization is opening up the definition of airborne pathogens – such as Covid-19, influenza and measles – to include when respiratory droplets spread through the air and when they land on a person, regardless of the size of the droplet. [CNN Health] |
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| May 6 – 9, 2024 Killarney, Ireland |
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| St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| Aarhus University – Aarhus, Denmark |
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| Cold Spring Harbor Laboratory – Cold Spring Harbor, New York, United States |
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| Indiana University School of Medicine – Indianapolis, Indiana, United States |
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| University of Washington – Medical Lake, Washington, United States |
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