Dengue Virus Envelope Protein Domain I/II Hinge Determines Long-Lived Serotype-Specific Dengue Immunity Scientists showed that the envelope glycoprotein domain I/II hinge of dengue virus (DENV)-3 and DENV-4 is the primary target of the long-term type-specific neutralizing antibodies response in humans. [Proc Natl Acad Sci USA] Abstract STING-Dependent Type I IFN Production Inhibits Cell-Mediated Immunity to Listeria monocytogenes The authors examined the role of STING in the development of protective cell-mediated immunity to L. monocytogenes. Mice deficient for STING or its downstream effector IRF3 restricted a secondary lethal challenge with L. monocytogenes and exhibited enhanced immunity that was MyD88-independent. [PLoS Pathog] Full Article C-Type Lectin Receptors Differentially Induce Th17 Cells and Vaccine Immunity to the Endemic Mycosis of North America Investigators showed that C-type lectin receptors exert divergent contributions to the development of antifungal Th17 cells and vaccine resistance against Blastomyces dermatitidis, Histoplasma capsulatum, and Coccidioides posadasii. [J Immunol] Abstract Virus Specific Cell-Mediated Immunity May Play a Role in Controlling Reactivated Human Herpesvirus 6B in Patients Under Measles Induced Immunosuppression For a better understanding of the cellular immune responses to reactivated human herpesvirus 6B (HHV 6B), the lymphoproliferative response to HHV 6B antigen was measured in three consecutive specimens obtained biweekly from 22 young children and infants suffering from acute measles, and in 19 influenza patients and nine healthy control subjects. [J Med Virol] Abstract HIV An Altered Intestinal Mucosal Microbiome in HIV-1 Infection Is Associated with Mucosal and Systemic Immune Activation and Endotoxemia Researchers investigated the impact of HIV-1 infection on the intestinal microbiome and its association with mucosal T-cell and dendritic cell frequency and activation, as well as with levels of systemic T-cell activation, inflammation, and microbial translocation. [Mucosal Immunol] Abstract Reduced Markers of HIV Persistence and Restricted HIV-Specific Immune Responses after Early Antiretroviral Therapy in Children The authors measured the markers of HIV persistence and HIV-specific immunity in early treated children. They performed a cross-sectional study that enrolled 15 children older than 2 years of age who initiated antiretroviral therapy before 6 months of age and had sustained viral suppression. [AIDS] Abstract The Majority of CD4+ T-Cell Depletion during Acute SHIV89.6P Infection Occurs in Uninfected Cells Investigators fit mathematical models to data from experiments testing an HIV eradication strategy in which five macaques with a proportion of CD4+ T-cells resistant to SHIV entry were challenged with SHIV89.6P, a highly pathogenic dual tropic chimeric SIV-HIV viral strain that results in rapid loss of both SHIV- susceptible and SHIV-resistant CD4+ T-cells. [J Virol] Abstract Higher CD27+CD8+ T Cells Percentages during Suppressive Antiretroviral Therapy Predict Greater Subsequent CD4+ T Cell Recovery in Treated HIV Infection Scientists analyzed cellular biomarkers of immunological inflammation, maturation, and senescence in HIV-infected subjects on early suppressive antiretroviral therapy (ART). They performed longitudinal analyses of peripheral immunological biomarkers of subjects on suppressive ART from early treatment to 1-2 years of follow-up. [PLoS One] Full Article |