PCSK9 Is a Critical Regulator of the Innate Immune Response and Septic Shock Outcome The authors show that reduced proprotein convertase subtilisin/kexin type 9 (PCSK9) function is associated with increased pathogen lipid clearance via the low-density lipoprotein receptor, a decreased inflammatory response, and improved septic shock outcome. [Sci Transl Med] Abstract | Press Release ‘Division of Labor’ in Response to Host Oxidative Burst Drives a Fatal Cryptococcus gattii Outbreak Investigators show that a subpopulation of intracellular C. gattii adopts a tubular mitochondrial morphology in response to host reactive oxygen species. These fungal cells then facilitate the rapid growth of neighboring C. gattii cells with non-tubular mitochondria, allowing for effective establishment of the pathogen within a macrophage intracellular niche. [Nat Commun] Full Article | Press Release ​Interleukin-1α Released from HSV-1-Infected Keratinocytes Acts as a Functional Alarmin in the Skin The authors report that herpes simplex virus-1 (HSV-1)-infected keratinocytes actively release the also pro-inflammatory ​interleukin (IL)-1α, preserving the ability of infected cells to signal danger to the surrounding tissue. In vivo recruitment of leukocytes to early HSV-1 microinfection sites within the epidermis is dependent upon IL-1 signaling. [Nat Commun] Abstract Role of Disease-Associated Tolerance in Infectious Superspreaders Investigators show that superspreader hosts remain asymptomatic when they are treated with oral antibiotics. In contrast, nonsuperspreader Salmonella-infected hosts that are treated with oral antibiotics rapidly shed superspreader levels of the pathogen but display signs of morbidity. This morbidity is linked to an increase in inflammatory myeloid cells in the spleen followed by increased production of acute-phase proteins and proinflammatory cytokines. [Proc Natl Acad Sci USA] Abstract | Press Release Female Resistance to Pneumonia Identifies Lung Macrophage Nitric Oxide Synthase-3 as a Therapeutic Target To identify new approaches to enhance innate immunity to bacterial pneumonia, scientists investigated the natural experiment of gender differences in resistance to infections. In vitro, lung macrophages from female mice and humans show better killing of ingested bacteria. [eLife] Abstract | Full Article | Editorial Protection and Mechanism of Action of a Novel Human Respiratory Syncytial Virus Vaccine Candidate Based on the Extracellular Domain of Small Hydrophobic Protein Scientists demonstrate that a vaccine based on the extracellular domain (SHe) of the small hydrophobic (SH) protein of human respiratory syncytial virus, reduced viral replication in challenged laboratory mice and in cotton rats. Using a conditional cell depletion method, they provide evidence that alveolar macrophages are involved in the protection by SHe-specific antibodies. [EMBO Mol Med] Full Article | Press Release HIV Slaying the Trojan Horse: Natural Killer Cells Exhibit Robust Anti-HIV-1 Antibody-Dependent Activation and Cytolysis against Allogeneic T-Cells As HIV-1 vaccines need to elicit immune responses capable of controlling both free and cell-associated virus, researchers evaluated the potential of natural killer cells to respond in an antibody-dependent manner to allogeneic T-cells bearing HIV-1 antigens. [J Virol] Abstract Contact-Induced Mitochondria Polarization Supports HIV-1 Virological Synapse Formation Investigators report that contact between an HIV-1 infected T cell and an uninfected target T cell specifically triggers polarization of mitochondria concomitant with recruitment of the major HIV-1 structural protein Gag to the site of cell-cell contact. [J Virol] Abstract | Full Article Shorter Telomere Length Predicts Poorer Immunological Recovery in Virologically Suppressed HIV-1 Infected Patients Treated with Combined Antiretroviral Therapy Because telomere dysregulation can lead to an abnormal cell proliferation, researchers hypothesized that lack of CD4 recovery may be related to telomere defects so they evaluated the association between telomere length and CD4+ T-cell recovery 48 weeks aftercombined antiretroviral therapy initiation in virologically suppressed patients, and its possible relation with the oxidative and nitrosative stress markers. [J Acquir Immune Defic Syndr] Abstract Suppression of Foxo1 Activity and Down-Modulation of CD62L (L-Selectin) in HIV-1 Infected Resting CD4 T Cells Investigators report that HIV-1 down-modulates CD62L in productively infected naïve and memory resting CD4 T cells while suppressing Foxo1 activity and the expression of KLF2 mRNA. Partial T cell activation was further evident as an increase in CD69 expression. [PLoS One] Full Article Don’t forget to subscribe to our sister publications: Human Immunology News and Immune Regulation News! |