A Spaetzle-Like Role for Nerve Growth Factor β in Vertebrate Immunity to Staphylococcus aureus Nerve growth factor β was released by macrophages in response to S. aureus exoproteins through activation of the NOD-like receptors NLRP3 and NLRP4 and enhanced phagocytosis and superoxide-dependent killing, stimulated proinflammatory cytokine production, and promoted calcium-dependent neutrophil recruitment. [Science] Abstract Autophagy Is Essential for Effector CD8+ T Cell Survival and Memory Formation Researchers report that autophagy was dynamically regulated in virus-specific CD8+ T cells during acute infection of mice with lymphocytic choriomeningitis virus. In contrast to the current paradigm, autophagy decreased in activated proliferating effector CD8+ T cells and was then upregulated when the cells stopped dividing just before the contraction phase. [Nat Immunol] Abstract CD28 Expression Is Required after T Cell Priming for Helper T Cell Responses and Protective Immunity to Infection Investigators show that continued CD28 expression is important for effector CD4+ T cells following infection; maintained CD28 is required for the expansion of T helper type 1 cells, and for the differentiation and maintenance of T follicular helper cells during viral infection. [eLife] Abstract | Full Article Failure of Antigen-Specific CD4+ T Cell Recruitment to the Kidney during Systemic Candidiasis Using Ag-loaded immunoliposomes to artificially reverse the defective migration of Ag-specific CD4+ T cells into infected kidneys, scientists show that recruited cells polarize toward a Th17 phenotype in the kidney and are protective during fungal infection. [J Immunol] Abstract | Full Article CD4+ T Cell Help Is Dispensable for Protective CD8+ T Cell Memory against Mousepox following Vaccinia Virus Immunization Researchers show that CD4+ T helper cells play a role but are not essential for the maintenance, proliferation and effector differentiation of polyclonal memory CD8+ T cells after infection with wild type vaccinia virus WR. [J Virol] Abstract HIV CD4 Depletion in SIV-Infected Macaques Results in Macrophage and Microglia Infection with Rapid Turnover of Infected Cells Scientists used the rhesus recombinant anti-CD4 antibody CD4R1 to deplete RM CD4+ T-cells prior to SIVmac251 infection and investigated the sources of the increased viral burden and the lifespan of productively infected cells. [PLoS Pathog] Full Article | Press Release Multiplexing 7 miRNA-Based shRNAs to Suppress HIV Replication The authors describe a simple strategy to express a large number of miRNA-based shRNAs (shRNA-miR) using minimal flanking sequences from multiple endogenous miRNAs. The lentiviral construct was pseudotyped with HIV-1 envelope to allow transduction of both resting and activated primary CD4 T cells. Unlike single shRNA-miRs, the 7shRNA-miR transduced T cells nearly abrogated HIV-1 infection in vitro. [Mol Ther] Abstract Virological and Immunological Characterization of Novel NYVAC-Based HIV/AIDS Vaccine Candidates Expressing Clade C Trimeric Soluble gp140(ZM96) and Gag(ZM96)-Pol-Nef(CN54) as VLPs Analysis of the immune responses elicited in mice after homologous NYVAC prime/NYVAC boost immunization shows that recombinant viruses induced polyfunctional Env-specific CD4 or Gag-specific CD8 T cell responses. [J Virol] Abstract Reconstitution of Intestinal CD4 and Th17 T Cells in Antiretroviral Therapy Suppressed HIV-Infected Subjects: Implication for Residual Immune Activation from the Results of a Clinical Trial Researchers examined intestinal and peripheral CD4+ T-cell subsets reconstitution under combined antiretroviral therapy (cART) and systemic immune activation markers. Eight months of cART increased intestinal CD4+ and Th17 cells and reduced levels of T-cell activation and proliferation. [PLoS One] Full Article Don’t forget to subscribe to our sister publications: Human Immunology News and Immune Regulation News! |