Immunology of Infectious Disease News Volume 7.28 | Jul 24 2019

TOP STORY

The Secreted Kinase ROP17 Promotes Toxoplasma gondii Dissemination by Hijacking Monocyte Tissue Migration

Scientists analyzed the migration of parasitized monocytes in model endothelial and interstitial environments. They report that infection enhanced monocyte locomotion on the surface of endothelial cells, but profoundly inhibited monocyte transmigration across endothelial barriers. [Nat Microbiol] Abstract

(Ranked by impact factor of the journal)

Multimeric Epitope-Scaffold HIV Vaccines Target V1V2 and Differentially Tune Polyfunctional Antibody Responses

To focus immune responses on V1V2, the authors engrafted the native, glycosylated V1V2 domain onto five different multimeric scaffold proteins and conducted comparative immunogenicity studies in macaques. [Cell Rep] Full Article | Graphical Abstract

Multiple Viral Proteins and Immune Response Pathways Act to Generate Robust Long-Term Immunity in Sudan Virus Survivors

Scientists characterized antigen-specific immune responses in whole blood samples of fifteen years post-infected survivors of the Sudan virus (SUDV) outbreak in Gulu, Uganda. They examined T cell and IgG responses against SUDV complete antigen and four SUDV proteins; glycoprotein, nucleoprotein, and viral protein 30, and 40. [EBioMedicine] Full Article

Intraperitoneal Injection with Dengue Virus Type 1-Infected K562 Cells Results in Complete Fatality among Immunocompetent Mice

To contribute to the development of preventative measures, investigators established an immunocompetent-mouse infection model using dengue virus type 1 Mochizuki strain. [Antiviral Res] Abstract

HCV-Specific CD4⁺ T Cells of Patients with Acute and Chronic HCV Infection Display High Expression of TIGIT and Other Co-Inhibitory Molecules

Researchers found a higher expression level of TIGIT⁺ PD-1⁺ on HCV-specific CD4⁺ T cells during acute and chronic HCV infection compared to patients with spontaneously resolved HCV infection. [Sci Rep] Full Article

Antibody-Dependent IFN-γ-Independent Sterilizing Immunity, Induced by a Subunit Malaria Vaccine

The authors report that immunization with recombinant circumsporozoite protein from Plasmodium yoelli, when delivered in Montanide ISA 51, induced sterilizing immunity against sporozoite challenge in C57BL/6 and BALB/c strains of mice. [Infect Immun] Abstract

Staphylococcus aureus Lipoic Acid Synthesis Limits Macrophage Reactive Oxygen and Nitrogen Species Production to Promote Survival during Infection

Researchers found that enhanced innate immune cell activation after infection with a ΔlipA mutant was central to attenuation in vivo, whereas a growth defect imparted by the lipA mutation made a negligible contribution to overall clearance. [Infect Immun] Abstract

T Cell-Mediated Immunity in CBA Mice during Schistosoma japonicum Infection

Twenty CBA mice were infected with cercariae of S. japonicum and the immune response at different time points was determined. [Exp Parasitol] Abstract | Graphical Abstract

Combined Bivalent Human Papillomavirus Vaccine and Candida Antigen versus Candida Antigen Alone in the Treatment of Recalcitrant Warts

Investigators evaluated the potential therapeutic role of combined bivalent human papillomavirus vaccine and Candida antigen versus Candida antigen alone in the treatment of multiple recalcitrant warts. [J Cosmet Dermatol] Abstract

Subscribe to our sister publications: Human Immunology News & Immune Regulation News.

γδ T‐Cell Responses during HIV Infection and Antiretroviral Therapy

The authors review the impact of acute, chronic untreated and treated HIV infection on circulating and mucosal γδ T‐cell subsets and highlight novel approaches to harness γδ T cells as components of anti‐HIV immunotherapy. [Clin Transl Immunology] Full Article

Visit our reviews page to see a complete list of reviews in the immunology of infectious disease research field.

Spring Bank Announces Research Agreement with The National Institute of Allergy and Infectious Diseases to Evaluate HBV Antisense Oligonucleotide Compounds

Spring Bank Pharmaceuticals, Inc. announced that it has entered into a research agreement with The National Institute of Allergy and Infectious Diseases to evaluate Spring Bank’s hepatitis B virus (HBV) antisense oligonucleotide compounds. [Spring Bank Pharmaceuticals, Inc.] Press Release

Roche Expands the Global Access Program Beyond HIV to Also Include Diagnostic Tests for Tuberculosis, Hepatitis, and Human Papillomavirus

Roche announced the Global Access Program is expanding beyond HIV, to include Mycobacterium tuberculosis, hepatitis B and C, and human papillomavirus for low and middle income country programs where the disease burden is the highest. [Roche] Press Release

Science under Fire: Ebola Researchers Fight to Test Drugs and Vaccines in a War Zone

Violence in the Democratic Republic of the Congo has interrupted clinical trials and forced scientists to change how they immunize people. [Nature News] Editorial

A Vaunted Program for Boosting the Diversity of US Academic Scientists Is Starting to Spread

Many institutions already operate programs to attract and retain more minorities in STEM fields. But change is occurring at a glacial pace. Overall, black and Hispanic people each make up only about 4% of all tenured faculty at US PhD-granting institutions, percentages that have remained nearly flat for each group since 2013. And the numbers appear to be worse within the STEM disciplines. [ScienceInsider] Editorial

Mexico’s New President Shocks Scientists with Budget Cuts and Disparaging Remarks

A package of harsh austerity measures implemented, has had a deep impact on federally funded laboratories and institutes; it includes a 30% cut to fuel for vehicles and office supplies and a 50% cut to international travel funds and payments to contract workers. Scientists say the cuts are a serious threat to the future of Mexican research. [ScienceInsider] Editorial

NEW British Society for Immunology Congress 2019
December 2-5, 2019
Liverpool, United Kingdom

Visit our events page to see a complete list of events in the community.

NEW Scientific Communications Coordinator (STEMCELL Technologies Inc.)

NEW Postdoctoral Fellow – Influenza (University of Georgia)

Research Associate – Immune Cell Culture (STEMCELL Technologies Inc.)

Postdoctoral Research Fellow – Antibody-Mediated Protection of EBV (Fred Hutchinson Cancer Research Center)

Senior Staff Fellow – Viral Vaccines (Center for Biologics Evaluation and Research)

Postdoctoral Position – Mucosal Immunology (University of California, San Diego)

PhD Studentship – Infection, Immunology and Global Health Research (Karolinska Institutet)

Postdoctoral Position – Infectious Disease (National Institute of Health)

Postdoctoral Positions – Infectious Disease (The Laboratory for Molecular Infection Medicine)

Scientist – Infectious Diseases (Genentech, Inc.)

Research Associate – Immunology (Evotec)

Postdoctoral Position – Innate Immune Signaling in Spirochetal Diseases (UConn Health)

Postdoctoral Associate Positions – Infectious Diseases (University of Minnesota)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Immunology of Infectious Disease News? Click here to submit!

Comments or suggestions? Submit your feedback here.