 | | Vol. 8.26 – 15 July, 2020 |
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Investigators conducted a Phase I, dose-escalation, open-label trial including 45 healthy adults, 18 to 55 years of age, who received two vaccinations, 28 days apart, with mRNA-1273 in a dose of 25 μg, 100 μg, or 250 μg. There were 15 participants in each dose group.
[New England Journal of Medicine] |
|  | | PUBLICATIONSRanked by the impact factor of the journal |
| | | From a larger panel of human monoclonal antibodies targeting the spike glycoprotein, scientists identified several that exhibited potent neutralizing activity and fully blocked the receptor-binding domain of S from interacting with human ACE2.
[Nature] |
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| Researchers performed an integrated immune analysis on a cohort of 50 COVID-19 patients with various disease severity.
[Science] |
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| Scientists analyzed 294 anti-SARS-CoV-2 antibodies and found that IGHV3-53 was the most frequently used IGHV gene for targeting the receptor-binding domain of the spike protein.
[Science] |
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| Investigators used a rapid antibody discovery platform to isolate hundreds of human monoclonal antibodies against the SARS-CoV-2 spike protein.
[Nature Medicine] |
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| To identify SARS-CoV-2 neutralizing antibodies, the authors analyzed the antibody response of 12 COVID-19 patients from 8 to 69 days post diagnosis.
[Cell] |
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| Researchers determined cryo-EM structures for RaTG13 S and for both furin-cleaved and uncleaved SARS-CoV-2 spike protein (S); they compared these with recently reported structures for uncleaved SARS-CoV-2 S.
[Nature Structural & Molecular Biology] |
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| Scientists observed remarkably high and dose-dependent SARS-CoV-2 specific antibody titers in mouse sera, as well as robust neutralization of both a pseudo-virus and wild-type virus.
[Nature Communications] |
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| Investigators constructed a SARS-CoV-2 proteome microarray containing 18 out of the 28 predicted proteins and applied it to the characterization of the IgG and IgM antibodies responses in the sera from 29 convalescent patients.
[Nature Communications] |
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| Scientists report that remdesivir potently inhibited SARS-CoV-2 replication in human lung cells and primary human airway epithelial cultures.
[Cell Reports] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Researchers investigated the impact of therapeutic vaccination inducing virus-specific CD8+ T-cell responses under anti-retroviral therapy on viral control in a macaque AIDS model.
[Scientific Reports] |
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| Scientists studied the relationship between macrophages and HIV-2, focusing on post-entry steps. HIV-2-infected monocyte-derived macrophages produced substantial amounts of viral particles that were largely harbored intracellularly.
[Frontiers in Microbiology] |
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| Investigators showed that two FDA-approved Na+/K+-ATPase inhibitors, ouabain and digoxin, could block Zika virus infection at the replication stage by targeting Na+/K+-ATPase.
[Communications Biology] |
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| Comprehensive studies are urgently needed to define clinical correlates of protective immunity against SARS-CoV-2. Since scientists cannot predict antibody-dependent enhancement of disease reliably after either vaccination or treatment with antibodies, regardless of what virus is the causative agent, it will be essential to depend on careful analysis of safety in humans as immune interventions for COVID-19 disease move forward.
[Nature] |
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| The rapid development, distribution and administration of a vaccine to the global population is the most effective approach to quell this pandemic and the only one that will lead to a complete lifting of restrictions.
[Nature Nanotechnology] |
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| Angiotensin-converting enzyme 2 (ACE2) catalyzes angiotensin II conversion to angiotensin-(1–7), and the ACE2/angiotensin-(1–7)/MAS axis counteracts the negative effects of the renin-angiotensin, which plays important roles in maintaining the physiological and pathophysiological balance of the body.
[Critical Care] |
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| So far, sub-Saharan Africa has not faced the extreme numbers of cases and deaths from the novel coronavirus some public health experts feared would occur. Yet the numbers across Africa are ticking up, and Chikwe Ihekweazu, director of the Nigeria Centre for Disease Control, is far from complacent.
[Science Insider] |
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| More than six months into the pandemic, the virus’ potential to evolve in a nastier direction-or, if we’re lucky, become more benign-is unclear. In part that’s because it changes more slowly than most other viruses, giving virologists fewer mutations to study.
[Science Insider] |
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| China’s wildlife trade should be thoroughly investigated as part of efforts to uncover the origin of the coronavirus pandemic, say researchers. The call comes as the World Health Organization is sending scientists to China this weekend, ahead of plans for a larger international research team to probe the pandemic’s origin.
[Nature News] |
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| PDS Biotechnology Corporation announced that PDS Biotech collaborator, Professor J. Woodward of the University of Kentucky School of Medicine, has been awarded a grant from the National Institute of Allergy and Infectious Diseases’ Collaborative Influenza Vaccine Innovation Centers program to progress development of a Versamune®-based universal influenza vaccine.
[PDS Biotechnology Corporation] |
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| September 24 – September 25
Virtual |
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| | University of Würzburg – Würzburg, Germany |
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| | University of British Columbia – Vancouver, British Columbia, Canada |
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| | Ohio State University – Columbus, Ohio, United States |
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| | Terasaki Institute for Biomedical Innovation – Los Angeles, California, United States |
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| | Lund University – Lund, Sweden |
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