 | | Vol. 8.33 – 02 September, 2020 |
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| Of the 1797 persons who had recovered from SARS-CoV-2 infection, 1107 of the 1215 who were tested were seropositive; antiviral antibody titers assayed by two pan-Ig assays increased during two months after diagnosis by qPCR and remained on a plateau for the remainder of the study.
[New England Journal of Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists examined sex differences in viral loads, SARS-CoV-2-specific antibody titers, plasma cytokines, as well as blood cell phenotyping in COVID-19 patients.
[Nature] |
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| Using a transposon-mediated gene-activation screen in human cells, researchers identified that the MHC class II transactivator (CIITA) had antiviral activity against ebola virus.
[Science]Full Article |
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| NASAR mRNAs delivered by lipid‐derived TT3 nanoparticles triggered a dramatic expression of potential SARS‐CoV‐2 antigens.
[Advanced Materials] |
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| Scientists ccompared the immunopathology of COVID-19 acute respiratory distress syndrome (ARDS) to that of non-COVID-19 ARDS, and identified biomarkers associated with mortality in patients with COVID-19 ARDS.
[American Journal of Respiratory and Critical Care Medicine] |
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| Researchers generated a versatile imaging probe using recombinant Spike receptor binding domain conjugated to fluorescent quantum dots. This probe was capable of engaging in energy transfer quenching with ACE2-conjugated gold nanoparticles to enable monitoring of the binding event in solution.
[ACS Nano] |
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| Investigators showed the prodrug and its parent GC373 were effective inhibitors of the Mpro from both SARS-CoV and SARS-CoV-2 with IC50 values in the nanomolar range.
[Nature Communications] |
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| The authors describe an unbiased, system-wide and time-resolved analysis of the proteome and phosphoproteome of human cells infected with coxsackievirus B3.
[Nature Communications] |
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| In a cohort of 59 recovered patients with disease severity including severe, moderate, mild, and asymptomatic, scientists observed the positive correlation between serum neutralizing capacity and disease severity.
[Signal Transduction and Targeted Therapy] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Investigators revealed the functional diversity of hemocytes, with different subtypes of granulocytes expressing distinct and evolutionarily conserved subsets of effector genes.
[Science] |
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| Dual-CAR T cells exhibited expansion kinetics that exceeded 4-1BB-, CD28- and third-generation costimulated CAR T cells, elicited effector functions equivalent to CD28-costimulated CAR T cells and prevented HIV-induced CD4+ T cell loss despite persistent viremia.
[Nature Medicine] |
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| Highly multimerized immunogens preferentially rapidly activated cognate B cells, with little affinity discrimination.
[Immunity] |
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| The authors evaluated the presence of plasma bnAbs in a cohort of 51 HIV-1 clade-C infected infants and identify viral factors associated with early broadly neutralizing antibodies responses.
[Nature Communications] |
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| Scientists identified and characterized a multidonor antibody class targeting the hemagglutinin head.
[Cell Reports] |
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| Researchers report that plasmacytoid dendritic cells constitutively populated naïve corneas and were increased during sterile injuries or acute herpes simplex virus 1 keratitis.
[Cell Reports] |
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| Investigators revisit the current classification of memory subsets, elaborate on functional and migratory properties attributed to central memory CD8 T cells (Tcm), Tem, and Trm, and discuss how potential heterogeneity within these populations arises and persists.
[Cold Spring Harbor Perspectives in Biology] |
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| Investigators summarize the recent findings that contribute to deciphering the molecular mechanisms downstream of glucocorticoid receptor activation.
[Cellular & Molecular Immunology]
Full Article
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| Everest Medicines announced that it completed patient enrollment for its Phase III clinical trial of eravacycline for the treatment of complicated intra-abdominal infections in patients in China.
[Everest Medicines] |
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| AZD1222 development expanded into a Phase III clinical trial in the US to assess its safety, efficacy and immunogenicity.
[BusinessWire, Inc.] |
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| Laurent Pharmaceuticals Inc. announced that it has received approval from the FDA to start enrolling US patients in RESOLUTION, a multicentric Phase II randomized placebo-controlled trial testing once-a-day oral LAU-7b as a potential treatment against COVID-19 disease.
[Laurent Pharmaceuticals Inc.] |
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| In March and April, when national statistics offices began to release tallies of the number of deaths, it confirmed his suspicions: the pandemic was killing a lot more people than the COVID-19 figures alone would suggest.
[Nature News] |
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| The Africa Regional Certification Commission, an independent body responsible for overseeing the eradication of polio, has certified that all 47 countries in the WHO’s Africa Region have eradicated the virus after a long programme of vaccination and surveillance.
[Nature News] |
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| | Benaroya Research Institute at Virginia Mason – Seattle, Washington, United States |
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| | STEMCELL Technologies – Flexible |
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| | The Research Institute at Nationwide Children’s Hospital – Columbus, Ohio, United States |
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| | Princeton University – Princeton, New Jersey, United States |
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| | Rush University Medical Center – Chicago, Illinois, United States |
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