 | | Vol. 8.40 – 21 October, 2020 |
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| In vitro, dACE2, which lacked 356 amino-terminal amino acids, was non-functional in binding the SARS-CoV-2 spike protein and as a carboxypeptidase.
[Nature Genetics] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors constructed a VH-phage library and targeted the angiotensin-converting enzyme 2 binding interface of the SARS-CoV-2 Spike receptor-binding domain.
[Nature Chemical Biology] |
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| Researchers analyzed the viral genome on maternal and newborns nasopharyngeal swabs, vaginal swabs, maternal and umbilical cord plasma, placenta and umbilical cord biopsies, amniotic fluids and milk from 31 mothers with SARS-CoV-2 infection.
[Nature Communications] |
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| Scientists present a high-throughput nanoluciferase severe respiratory syndrome coronavirus 2 that was genetically stable and replicated similarly to the wild-type virus in cell culture.
[Nature Communications] |
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| Investigators report high-speed in vitro selection of multiple high-affinity antibody-like proteins against various targets including the SARS-CoV-2 spike protein.
[Science Advances] |
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| Using single-cell RNA sequencing, researchers characterized the peripheral blood mononuclear cells from uninfected controls and COVID-19 patients and cells in paired broncho-alveolar lavage fluid.
[Cell Discovery] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Researchers tested the antiviral potential of MAIT cells, and investigated their dynamic changes and regulating factors during chronic HBV infection.
[Hepatology] |
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| Scientists showed changes in the abundance and activation states of more than 50 immune cell subsets in 35 individuals over 11 time points during human A/California/2009 (H1N1) virus challenge monitored using mass cytometry along with other clinical assessments.
[Journal of Clinical Investigation] |
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| The authors investigated how flaviviruses exploit Src family kinases for exit from infected cells. They identifyied Lyn as a critical component for secretion of Dengue and Zika infectious particles and their corresponding virus like particles.
[Nature Communications] |
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| Investigators demonstrated that envelope glycoproteins (Env)-induced oxidative stress was responsible for their death by apoptosis. Moreover, they report that peroxisomes, organelles involved in the control of oxidative stress, are targeted by Env-mediated autophagy.
[Autophagy] |
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| Pregnant rhesus macaques were infected with HEV to explore the pathogenesis of genotype 4 HEV infection during pregnancy. Active HEV infections were established with shedding viruses in the feces and blood, and elevated liver enzymes.
[Scientific Reports] |
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| The authors investigate future possibilities of materials science in antiviral research and treatment development, examining the role of materials in antiviral-drug design, including the importance of synthetic material platforms for organoids and organs-on-a-chip, in drug delivery and vaccination, and for the production of medical equipment.
[Nature Reviews Materials] |
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| Scientists discuss recent insights into herpesvirus entry by analyzing the structures of entry glycoproteins, including the diverse receptor-binding glycoproteins, as well gH–gL and the fusion protein gB, which are conserved in all herpesviruses.
[Nature Reviews Microbiology] |
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| Insights into the pathogenic mechanisms underlying SARS-CoV-2 infection and COVID-19 progression are emerging and highlight the critical role of the immunological hyper-response – characterized by widespread endothelial damage, complement-induced blood clotting and systemic microangiopathy – in disease exacerbation.
[Nature Reviews Nephrology] |
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| Orion Biotechnology Canada Ltd. announced the results of their Phase I study of OB-002H which is an investigational candidate microbicide for HIV prevention.
[Orion Biotechnology Canada Ltd.] |
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| Arch Biopartners, Inc. announced it has dosed the first patient in the Phase II trial of its lead drug LSALT peptide, targeting prevention of acute lung injury, acute kidney injury and other complications caused by inflammation in hospitalized patients with moderate to severe cases of COVID-19.
[Arch Biopartners, Inc.] |
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| Unchecked ivermectin use in the region is making it difficult to test the anti-parasite drug’s effectiveness against the coronavirus.
[Nature News] |
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| Proponents of the trials say they can be run safely and help to identify effective vaccines, but others have questioned their value.
[Nature News] |
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| One of the world’s largest nongovernmental funders of science, the Wellcome Trust, is enlarging its focus to include goal-oriented, as well as basic research. The London-based philanthropy, which spends more than £1 billion per year, said it will boost funding for research on infectious diseases, the health effects of global warming, and mental health.
[ScienceInsider] |
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| April 9 – April 14, 2021
Washington, DC, United States |
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| | Swiss Federal Institute of Technology in Lausanne – Lausanne, Vaud, Switzerland |
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| | Rheinische Friedrich-Wilhelms-Universität – Bonn, Germany |
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| | Purdue University – West Lafayette, Indiana, United States |
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| | Lerner Research Institute – Cleveland, Ohio, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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