 | | Vol. 8.41 – 28 October, 2020 |
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| The authors demonstrated that respiratory viral infection induces distinct fibroblast activation states, which they term extracellular matrix-synthesizing, damage-responsive and interferon-responsive states. They provide evidence that excess activity of damage-responsive lung fibroblasts drives lethal immunopathology during severe influenza virus infection.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators report a feeder-free, scalable, chemically-defined, and modular alveolosphere culture system for propagation and differentiation of human alveolar type 2 cells/pneumocytes derived from primary lung tissue.
[Cell Stem Cell] |
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| Researchers developed a feeder-free, long-term three-dimensional culture technique for human lung alveolar type 2 cells derived from primary human lung tissue, and investigate infection response to SARS-CoV-2.
[Cell Stem Cell] |
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| Scientists used an unbiased, genome-wide screening technology to determine the precise peptide sequences in SARS-CoV-2 that were recognized by the memory CD8+ T cells of COVID-19 patients.
[Immunity] |
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| The authors adapted a CRISPR-Cas9 system to carbapenem-resistant Klebsiella pneumoniae (CRKP) to elucidate how mutations in clinical CRKP isolates induce polymyxin resistance (PR). They demonstrated that CrrB was a positive regulator of PR, and common clinical mutations lead to the addition of both 4-amino-4-deoxy-L-arabinose and phosophethanolamine to lipid A.
[Cell Reports] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Scientists showed that low levels of P. falciparum parasites persist in the blood of asymptomatic Malian individuals during the five to six month dry season, rarely causing symptoms and minimally affecting the host immune response.
[Nature Medicine] |
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| By mapping the long-term development of CD8+ T cell families derived from single naive precursors, researchers found that fate decisions made during the acute phase of murine cytomegalovirus infection could alter the level of memory inflation by more than 1,000-fold.
[Nature Immunology] |
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| By analyzing more than 500 monoclonal antibodies (mAbs) derived from B cells induced by numerous influenza virus vaccines and infections, investigators found mAbs targeting conserved neutralizing influenza virus hemagglutinin epitopes were polyreactive.
[Immunity] |
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| Scientists showed that human endogenous retroviruses activation in tumors leads to the up-regulation of hundreds of transcriptional suppressors, namely, Krüppel-associated box domain–containing zinc-finger family proteins.
[Science Advances] |
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| Investigators showed that the cytosolic pattern recognition receptor Nod-like Receptor CARD 4 suppressed, rather than facilitated, effector and memory CD4+ T-cell responses against Salmonella in mice.
[Nature Microbiology] |
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| Researchers present crystal structures of BBRF2 alone and in complex with BSRF1. BBRF2 has a compact globular architecture featuring a central β-sheet that is surrounded by ten helices, it represented a novel fold distinct from other known protein structures.
[Nature Communications] |
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| Investigators established cell lines expressing each of the human Arfs fused to a fluorescent tag and investigated their behavior during enterovirus infection.
[Journal of Virology] |
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| Scientists summarize the first discoveries that shape our current understanding of SARS-CoV-2 infection throughout the intracellular viral life cycle and relate that to our knowledge of coronavirus biology.
[Nature Reviews Microbiology] |
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| Researchers focus on direct and indirect interactions between bacteria and B cells and how such interactions regulate B-cell phenotype, namely antibody production and regulatory B-cell function.
[Mucosal Immunology] |
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| The authors discuss the mechanisms exploited by Gram-positive bacteria to circumvent killing by antimicrobial peptides. Specifically, the most clinically relevant genera, Streptococcus spp., Staphylococcus spp., Enterococcus spp. and Gram-positive bacilli, have been explored.
[Frontiers in Microbiology] |
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| VAXIL BIO LTD. announced that it has entered into a cooperative research and development agreement with USAMRIID under which USAMRIID will test CorVax™ for its ability to specifically prevent COVID-19 in mice.
[VAXIL BIO LTD. (GlobeNewswire, Inc.)] |
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| Symvivo Corporation announced that it is receiving advisory services and funding of up to $2.8 million from the National Research Council Industrial Research Assistance Program to support the clinical advancement of bacTRL-Spike™, the company’s oral, room temperature-stable DNA vaccine candidate for the prevention of COVID-19.
[Symvivo Corporation] |
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| April 11 – April 15, 2021
Killarney, Co. Kerry, Ireland |
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| | Swiss Federal Institute of Technology in Lausanne – Lausanne, Vaud, Switzerland |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| | Rheinische Friedrich-Wilhelms-Universität – Bonn, Germany |
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| | Lerner Research Institute – Cleveland, Ohio, United States |
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| | Purdue University – West Lafayette, Indiana, United States |
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