 | | Vol. 9.02 – 20 January, 2021 |
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| Scientists showed that a bacterial infection and bacterial toxins could trigger an immune response that leads to the production of dietary-antigen-specific IgE antibodies in mice, which were limited to the intestine.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators report on the humoral memory response in a cohort of 87 individuals assessed at 1.3 and 6.2 months after infection. They found that IgM, and IgG anti-SARS-CoV-2 spike protein receptor binding domain antibody titres decreased significantly with IgA being less affected.
[Nature] |
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| Researchers screened human monoclonal antibodies targeting the receptor binding domain of the viral spike protein via antibody library constructed from peripheral blood mononuclear cells of a convalescent patient.
[Nature Communications] |
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| Scientists found that SARS-CoV-2 replication induced a delayed interferon response in lung epithelial cells. By screening 16 putative sensors involved in sensing of RNA virus infection, they found that MDA5 and LGP2 primarily regulated IFN induction in response to SARS-CoV-2 infection.
[Cell Reports] |
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| The authors measured the binding affinity of predicted interactions between short linear motifs in the cytoplasmic tails of angiotensin-converting enzyme 2 and integrin β3 with proteins that mediated endocytic trafficking and autophagy.
[Science Signaling] |
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| Researchers studied cross-reactivity using a highly multiplexed peptide assay to generate an epitope-resolved view of IgG reactivity across all human coronaviruses in both COVID-19 convalescent and negative donors.
[Cell Reports Medicine] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Scientists showed that gut microbiota from previously infected hosts display enhanced resistance to infection. This long-term functional remodeling was associated with altered bile acid metabolism leading to the expansion of taxa that utilized the sulfonic acid taurine.
[Cell] |
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| Using sequential immunization of immunoglobulin-humanized mice expressing diverse unmutated VRC01-class antibody precursors, investigators elicited serum responses capable of neutralizing viruses bearing glycan276 and isolated multiple lineages of VRC01-class bnAbs.
[Immunity] |
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| Using a targeted small interfering RNA screen, scientists identified a viral inhibitor found in cowpox virus and other orthopoxviruses that bound to the host SKP1-Cullin1-F-box machinery and the essential necroptosis kinase receptor interacting protein kinase 3.
[Immunity] |
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| Researchers characterized the IFN-I sensitivity of 500 clonally derived HIV-1 isolates from the plasma and CD4+ T cells of 26 individuals sampled longitudinally after transmission or after antiretroviral therapy and analytical treatment interruption.
[Science Translational Medicine] |
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| Invasion of macrophages by L. monocytogenes induced mitochondrial Ca2+ (mtCa2+) uptake through the mtCa2+ uniporter, which in turn increased acetyl-coenzyme A production by pyruvate dehydrogenase.
[Nature Microbiology] |
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| The authors showed that, after both polyclonal and HIV-1-specific activation, CD8A T-cells from antiretroviral treatments displayed reduced autophagy-dependent degradation of lysosomal contents when compared to naturally HIV-1 protected elite controllers.
[Autophagy] |
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| GPI-anchored m36.4, a single-domain antibody targeting the coreceptor-binding site of gp120, was constructed with a lentiviral vector. Scientists verified that m36.4 was efficiently expressed on the plasma membrane of transduced TZM-bl cells and targeted lipid raft sites without affecting the expression of HIV receptors
[Cellular & Molecular Immunology] |
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| Researchers identified that STAT1 activation is independent of cytokines and JAKs at the early infection stage of some viruses, including influenza A virus.
[Cell Reports] |
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| Investigators review chemical methods for the generation of bispecific antibodies, showing that the newest examples of these techniques are worthy competitors to the industry-standard expression-based strategies.
[Nature Reviews Chemistry] |
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| Scientists summarize existing data on the replication of SARS-CoV-2 in different tissues in both patients and ex vivo models.
[Clinical Microbiology Reviews] |
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| The authors discuss how the healthy microbiota protects against pneumonia and how host factors and medical interventions alter the microbiota, thus influencing susceptibility to pneumonia.
[Science Translational Medicine] |
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| Phathom Pharmaceuticals, Inc. announced that it has completed patient enrollment in PHALCON-HP, a pivotal Phase III clinical trial of vonoprazan in combination with amoxicillin and vonoprazan in combination with amoxicillin and clarithromycin for the eradication of H. pylori infection.
[Phathom Pharmaceuticals, Inc. (Globe Newswire, Inc.)] |
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| Merck announced the FDA accepted for priority review a Biologics License Application for V114, Merck’s investigational 15-valent pneumococcal conjugate vaccine, for the prevention of invasive pneumococcal disease in adults 18 years of age and older.
[Merck (BusinessWire, Inc)] |
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| AvantGen, Inc. announced licensing of a panel of its anti-SARS-CoV-2 antibody clones to IGM Biosciences for COVID-19 therapy development.
[AvantGen, Inc. (BusinessWire, Inc)] |
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| February 3 – 5, 2021
Virtual |
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| | University of Strasbourg – Strasbourg, France |
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| | University of Gothenburg – Gothenburg, Sweden |
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| | Stanford School of Medicine – Stanford, California, United States |
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| | Salk Institute of Biological Studies – La Jolla, California, United States |
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| | Karolinska Institutet – Huddinge, Sweden |
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