 | | Vol. 9.08 – 3 March, 2021 |
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| Researchers report a trans-complementation system that produced single-round infectious SARS-CoV-2 that recapitulated authentic viral replication.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The receptor binding domain mutations provided tighter ACE2 binding and widespread escape from monoclonal antibody neutralization largely driven by E484K although K417N and N501Y acted together against some important antibody classes.
[Cell] |
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| Scientists examined the ability of B.1.1.7 to evade antibody responses elicited by natural SARS-CoV-2 infection or vaccination.
[Cell] |
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| Investigators analyzed peripheral blood immune responses in hospitalized SARS-CoV-2 infected pediatric patients and patients with Multisystem Inflammatory Syndrome in Children.
[Science Immunology] |
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| The authors developed and assessed the protective efficacy and immunogenicity of an inactivated SARS-CoV-2 vaccine in rhesus macaques.
[Nature Communications] |
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| Scientists investigated the seroprevalence of SARS-CoV-2 antibodies among blood donors in the cities of Wuhan, Shenzhen, and Shijiazhuang in China.
[Nature Communications] |
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| Researchers report that SARS-CoV-2 nsp12, the viral RNA-dependent RNA polymerase, suppressed host antiviral responses.
[Cellular & Molecular Immunology] |
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| By interrogating metabolic programs of immune cells in severe and recovered COVID-19 patients compared to other viral infections, researchers identified a unique population of T cells.
[Cell Reports] |
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| Scientists showed that SARS-CoV-2 engaged inflammasome and triggered pyroptosis in human monocytes, experimentally infected, and from patients under intensive care.
[Cell Death Discovery] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| The authors determined the effect of long-term CD8+ T cell depletion using a rhesusized anti-CD8β monoclonal antibody on barcoded SIVmac239 dynamics on stable ART.
[Journal of Clinical Investigation] |
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| Researchers showed that Group A Streptococcus extracellular protease ScpC N-terminally cleaved LL-37 into two fragments of 8 and 29 amino acids, preserving its bactericidal activity.
[Cell Reports] |
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| Investigators identified IL-33 as a critical regulator of the immune response to the enteric pathogen Citrobacter rodentium.
[Mucosal Immunology] |
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| Building upon the COBRA technology, nine next-generation H3N2 influenza hemagglutinin (HA) vaccines were designed using a next generation algorithm and design methodology.
[Scientific Reports] |
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| Scientists explore some of these recent findings that extend our understanding for proliferation, establishment and control of toxoplasmosis in humans.
[Nature Reviews Microbiology] |
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| The authors outline factors driving SARS-CoV-2 variant evolution, explore the potential impact of specific mutations, examine the risk of further mutations.
[Cell Host & Microbe] |
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| Different vaccine platforms are being used for vaccine development, each one presenting several advantages and disadvantages.
[npj Vaccines] |
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| Arch Biopartners, Inc. announced that the Peter Lougheed Center in Calgary, Alberta has joined the Phase II trial of its lead drug LSALT peptide, targeting the prevention of acute lung injury, acute kidney injury, and other complications caused by inflammation in hospitalized patients with moderate to severe cases of COVID-19.
[Arch Biopartners, Inc.] |
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| March 16 – 17, 2021
Virtual |
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| | The University of British Columbia- Vancouver, British Columbia, Canada |
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| | University of California Merced – Merced, California, United States |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| | NCCR AntiResist – Basel, Switzerland |
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| | UT Health Science Center at Tyler – Tyler, Texas, United States |
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