 | | Vol. 9.10 – 17 March, 2021 |
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| Researchers report findings from a multicenter Phase Ib–II trial in South Africa evaluating the safety, immunogenicity, and efficacy of the ChAdOx1 nCoV-19 vaccine in preventing symptomatic Covid-19.
[New England Journal of Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators describe a panel of human monoclonal antibodies binding to diverse epitopes on the N-terminal domain of S protein from SARS-CoV-2 convalescent donors and found a minority of these possessed neutralizing activity.
[Cell] |
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| Scientists evaluated the neutralization potency of 99 individuals that received one or two doses of either BNT162b2 or mRNA-1273 vaccines against pseudoviruses representing ten globally circulating strains of SARS-CoV-2.
[Cell] |
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| Researchers identified 309 host proteins that bound the SARS-CoV-2 RNA during active infection.
[Cell] |
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| In COVID-19 airways, T cells exhibited activated, tissue-resident, and protective profiles; higher T cell frequencies correlated with survival and younger age.
[Immunity] |
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| Researchers investigated SARS-CoV-2 antibody and T cell responses in matched samples of COVID-19 convalescent individuals up to six months post-infection.
[Science Translational Medicine] |
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| The authors report that ISG15 conjugation was essential for antiviral IFN responses mediated by the viral RNA sensor MDA5.
[Nature Microbiology] |
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| Scientists developed a medium-throughput drug screening system and identified a small molecule library of 34 of 430 protein kinase inhibitors that were capable of inhibiting SARS-CoV-2 cytopathic effect in human epithelial cells.
[Cell Reports] |
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| Investigators identified a dual-functional cross-linking peptide 8P9R which could inhibit the two entry pathways of SARS-CoV-2 in cells.
[Nature Communications] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Researchers used 16S rRNA gene sequencing and HLA peptidomics to identify a peptide repertoire derived from intracellular bacteria that was presented on HLA-I and HLA-II molecules in melanoma tumors.
[Nature] |
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| Scientists applied electron cryotomography and subtomogram averaging to describe the structural basis for hexagonal lattice formation by haemagglutinin-esterase-fusion on the viral surface.
[Nature Communications] |
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| The twenty-first century has already recorded more than ten major epidemic or pandemic virus emergence events. Rather than only focusing on known risks, dedicated efforts must be made toward pre-emptive research focused on outbreak-prone virus families, ultimately offering a strategy to shorten the gap between outbreak and response.
[Nature Medicine] |
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| Scientists discuss the current understanding of the bacterial effectors that manipulate the different stages of the host IFN response: IFN induction, downstream signaling pathways, and target ISGs.
[Frontiers in Cellular and Infection Microbiology] |
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| Moderna Inc. announced that the first participants have been dosed in the Phase II/III study, called the KidCOVE study, of mRNA-1273, the Company’s vaccine candidate against COVID-19, in children ages six months to less than 12 years.
[Moderna Inc. (BusinessWire, Inc)] |
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| March 29 – 30, 2021
Virtual |
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| | University of California Merced – Merced, California, United States |
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| | Uni Tübingen- Tübingen, Germany |
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| | The University of British Columbia- Vancouver, British Columbia, Canada |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| | NCCR AntiResist – Basel, Switzerland |
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