Immunology of Infectious Disease News Volume 9.11 | Mar 24 2021

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    IIDN 9.11 | Mar 24 2021


    Immunology of Infectious Disease News by STEMCELL Technologies
    Vol. 9.11 – 24 March, 2021
    TOP STORY

    A Non-Canonical Type 2 Immune Response Coordinates Tuberculous Granuloma Formation and Epithelialization

    Researchers found that type 2 immune signaling, mediated via stat6, was absolutely required for epithelialization and granuloma formation.
    [Cell]

    AbstractGraphical Abstract

    Quantify Cytokines with Confidence with High-Performance ELISA Kits
    PUBLICATIONSRanked by the impact factor of the journal

    SARS-CoV-2 Variants B.1.351 and P.1 Escape from Neutralizing Antibodies

    Using pseudoparticles, researchers showed that entry of all variants into human cells was susceptible to blockade by the entry inhibitors soluble ACE2, Camostat, EK-1 and EK-1-C4.
    [Cell]

    AbstractFull Article

    Infection and Vaccine-Induced Antibody Binding and Neutralization of the B.1.351 SARS-CoV-2 Variant

    The authors compared antibody binding and live virus neutralization of sera from naturally infected and Moderna vaccinated individuals against two SARS-CoV-2 variants.
    [Cell Host & Microbe]

    AbstractFull ArticleGraphical Abstract

    Membrane Nanoparticles Derived from ACE2-Rich Cells Block SARS-CoV-2 Infection

    Membrane nanoparticles prepared from ACE2-rich cells were discovered to have potent capacity to block SARS-CoV-2 infection.
    [ACS Nano]

    AbstractGraphical Abstract

    Exposure to SARS-CoV-2 Generates T-Cell Memory in the Absence of a Detectable Viral Infection

    Scientists demonstrated the size and quality of the memory T-cell pool of COVID-19 patients were larger and better than those of close contacts.
    [Nature Communications]

    Full Article

    Chronic Infection Drives Dnmt3a-Loss-of-Function Clonal Hematopoiesis via IFNγ Signaling

    Investigators created Dnmt3a-mosaic mice by transplanting Dnmt3a−/− and WT hematopoietic stem cells into WT mice and observed the substantial expansion of Dnmt3a−/− HSCs during chronic mycobacterial infection.
    [Cell Stem Cell]

    AbstractGraphical Abstract

    Effector Function Does Not Contribute to Protection from Virus Challenge by a Highly Potent HIV Broadly Neutralizing Antibody in Nonhuman Primates

    Researchers used variants of the potent HIV bnAb, PGT121, to investigate whether Fc receptor function was required for the protective effects elicited by antibody treatment.
    [Science Translational Medicine]

    Abstract

    The Shape of Pleomorphic Virions Determines Resistance to Cell-Entry Pressure

    Scientists suggest that therapeutics targeting filamentous virus particles could overcome antiviral drug resistance and immune evasion in pleomorphic viruses.
    [Nature Microbiology]

    Abstract

    Robust Hepatitis B Vaccine-Reactive T Cell Responses in Failed Humoral Immunity

    Investigators showed that HBV-reactive polyfunctional T cells were present in the majority of hemodialysis patients even if humoral immunity failed.
    [Molecular Therapy-Methods & Clinical Development]

    AbstractFull ArticleGraphical Abstract

    Explore Antibodies for Immunology Research
    REVIEWS

    Novel Approaches for Vaccine Development

    The authors discuss the current state of RNA vaccines, recombinant adenovirus vector-based vaccines, and advances from biomaterials and engineering that address these important public health challenges.
    [Cell]

    Abstract

    Antivirals with Common Targets against Highly Pathogenic Viruses

    Scientists reviewed the development of antivirals with common targets, including those against the same protein across viruses, or the same viral function, to provide clues for development of antivirals for future epidemics.
    [Cell]

    Abstract

    The Struggle of a Good Friend Getting Old: Cellular Senescence in Viral Responses and Therapy

    The authors describe which sequelae due to viral infections and treatment can be partly due to excessive and aberrant senescence.
    [EMBO Reports]

    Full Article

    INDUSTRY AND POLICY NEWS

    Organicell and The Centers for Disease Control and Prevention Enter Into Agreement to Conduct Research on Influenza Viruses of Pandemic Potential

    Organicell Regenerative Medicine, Inc. announced that it has entered into a Material Cooperative Research and Development Agreement with the Centers for Disease Control and Prevention to determine the anti-inflammatory and anti-infective effectiveness of Zofinâ„¢ in experimental models of influenza infection.
    [Organicell Regenerative Medicine, Inc. (BusinessWire, Inc.)]

    Press Release

    Dyadic and Medytox to Develop Vaccines against COVID-19 Variants

    Dyadic International, Inc. announced that the Company has expanded its partnership with South Korea’s Medytox, Inc. Dyadic and Medytox will co-develop C1 manufactured COVID-19 vaccines and/or boosters, which will, if successful, be used to immunize people against two or more of the current and future COVID-19 variants.
    [Dyadic International, Inc. (Globe Newswire, Inc.)]

    Press Release

    FEATURED EVENT

    America’s Antibody Congress (Festival of Biologics USA)

    March 29 – April 1, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    New Group Leaders – Microbiology and Infection Biology

    IPBS-Toulouse – Toulouse, France

    Full Professor – Translational Infectiology and Vaccine Development

    Uni Tübingen – Tübingen, Germany

    Postdoctoral Fellow – Human COVID Immunology

    Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

    Assistant Professor – Infectious Diseases

    University of California Merced – Merced, California, United States

    Postdoctoral Researcher – 3D In Vitro Systems for Respiratory Bacterial Infections

    NCCR AntiResist – Basel, Switzerland

    > See All Jobs

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