 | | Vol. 9.12 – 31 March, 2021 |
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| Researchers designed and synthesized 32 new bicycloproline-containing Mpro inhibitors derived from either boceprevir or telaprevir. All compounds inhibited SARS-CoV-2 Mpro activity in vitro.
[Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| In contrast, sera from convalescent or vaccinated individuals similarly bound the three spike proteins in a flow cytometry-based serological assay. Neutralizing antibodies were rarely detected in nasal swabs from vaccinees.
[Nature Medicine] |
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| Investigators found that the viral load was substantially reduced for infections occurring 12-37 days after the first dose of vaccine.
[Nature Medicine] |
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| Researchers present the development and validation of a rapid, low-cost, solution-based assay to detect antibodies in serum, plasma, whole blood and to a lesser extent saliva, using rationally designed split luciferase antibody biosensors.
[Nature Biotechnology] |
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| The authors suggest that, in severe COVID-19, SARS-CoV-2 triggered a chronic immune reaction that was instructed by TGF-β, and was distracted from itself.
[Nature Communications] |
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| Investigators profiled metabolic changes conferred by SARS-CoV-2 infection in kidney epithelial cells and lung air-liquid interface (ALI) cultures, and showed that SARS-CoV-2 infection increased glucose carbon entry into the TCA cycle via increased pyruvate carboxylase expression.
[Nature Communications] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Scientists assessed Th1 cell generation in vivo by studying antigen-specific CD4+ T cells during infection with the phagosomal pathogen Salmonella enterica, or influenza A virus, for which CD4+ T cells were less important.
[Immunity] |
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| The authors analyzed the transcriptome of CD4+ T cells from patients with HIV-1 and revealed that the elevated oxidative phosphorylation pathway was associated with poor outcomes.
[Nature Immunology] |
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| Researchers report that recombinant poliovirus therapy primarily mediated antitumor immunotherapy via direct infection of non-malignant tumor microenvironment cells, independent of malignant cell lysis.
[Nature Communications] |
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| Scientists report that during herpes simplex virus type 1 infection, two microRNAs whose levels significantly decreased due to their interaction with the lncRNA Oasl2-209 directly regulated the expression of cGAS.
[Cellular & Molecular Immunology] |
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| Tryptophan biosynthesis represents an important potential drug target for new anti-TB drugs. Scientists identified a series of indole-4-carboxamides with potent antitubercular activity.
[Cell Chemical Biology] |
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| Researchers found that HBV and HPV genotype and co-infection serve as significant predictors of patient survival and immune activation.
[iScience] |
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| Scientists summarize and discuss the current understanding of how neutrophils in the lung direct immune responses to viruses.
[Mucosal Immunology] |
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| The Clinical Research Forum announced Moderna and Pfizer as the recipients of the first ever Award for Extraordinary Impact on Health.
[The Clinical Research (CR) Forum (BusinessWire, Inc)] |
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| Curevo Vaccine announced that approval was granted to move forward with a Phase Ib pediatric clinical trial in South Africa to evaluate the safety, efficacy, and immunogenicity of its non-live investigational vaccine, CRV-101, against varicella in immunocompromised pediatric HIV-infected populations.
[Curevo Vaccine (BusinessWire, Inc)] |
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| April 12 – 15, 2021
Virtual |
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| | The University of Warwick – Coventry, England, United Kingdom |
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| | IPBS-Toulouse – Toulouse, France |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| | NCCR AntiResist – Basel, Switzerland |
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| | University of California Merced – Merced, California, United States |
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