 | | Vol. 9.14 – 14 April, 2021 |
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| The authors generated a library of Fc variants with identical antigen-binding fragments from an Ebola virus neutralizing antibody.
[Immunity] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists unexpectedly found that the complement system was one of the intracellular pathways most highly induced by SARS-CoV-2 infection in lung epithelial cells.
[Science Immunology] |
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| Investigators created a structure-based phylogenetic computational tool named 3DPhyloFold to systematically identify structurally similar serine proteases with known therapeutic inhibitors and demonstrated effective inhibition of SARS-CoV-2 infection in vitro and in vivo.
[Journal of Clinical Investigation] |
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| The authors developed primary human lung epithelial infection models to understand initial responses of proximal and distal lung epithelium to SARS-CoV-2 infection.
[Cell Reports] |
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| Researchers report that propagating SARS-CoV-2 on the human airway cell line Calu-3 prevented cell culture adaptations in the multibasic cleavage sites. Similar results were obtained using a human airway organoid-based culture system for SARS-CoV-2 propagation.
[eLife] |
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| Scientists report that SARS-CoV-2 productively infected both proximally and distally patterned human induced pluripotent stem cell-derived intestinal organoids, leading to the release of infectious viral particles while stimulating a robust transcriptomic response.
[Stem Cell Reports] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| The authors showed that HIV could penetrate the epithelial surface to interact with sub-epithelial resident mononuclear phagocytes in anogenital explants and defined the full array of subsets that were present in the human anogenital and colorectal tissues that HIV may encounter during sexual transmission.
[Nature Communications] |
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| Mycobacterium tuberculosis-specific CD4 T cells producing TNF-α, IL-2 and IL-17 were highly expanded in the lung compared to matched blood samples, in which IL-17+ cells were largely absent.
[Journal of Clinical Investigation] |
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| Scientists evaluated the activity of 13 non-neutralizing monoclonal antibodies against Mayaro virus, an emerging arthritogenic alphavirus.
[Cell Reports] |
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| Neonatal C57BL/6 alveolar macrophages mobilized very weakly the IFN-I pathway upon Respiratory Syncytial Virus (RSV) infection in vitro and failed to restrain virus replication.
[Mucosal Immunology] |
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| Researchers showed that mRNA-LNP immunization compared to protein immunization elicits either the same or superior magnitude and breadth of HIV-1 Env-specific polyfunctional antibodies.
[npj Vaccines] |
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| Scientists found that these neutrophil subtypes showed distinct migratory and motility patterns and different ability to interact with CD8 T cells in the spleen following vaccinia virus infection.
[npj Vaccines] |
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| Investigators designed two triplex droplet digital PCR assays, each with two unique targets and one in common, and normalize the results to PCR-based T cell counts.
[Cell Reports Medicine] |
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| The unprecedented scale and rapidity of dissemination of recent emerging infectious diseases pose new challenges for vaccine developers, regulators, health authorities and political constituencies.
[Nature Medicine] |
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| The authors summarize what is now known about adaptive immunity to SARS-CoV-2 and draw comparisons with immunity to other respiratory viruses, focusing on the longevity of protective responses.
[Trends in Microbiology] |
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| Kiniksa Pharmaceuticals, Ltd. announced the Phase II portion of the Phase II/III trial of mavrilimumab in non-mechanically-ventilated patients with severe COVID-19 pneumonia and hyperinflammation achieved its primary efficacy endpoint of the proportion of patients alive and free of mechanical ventilation at Day 29.
[Kiniksa Pharmaceuticals, Ltd. (Globe Newswire, Inc.)] |
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| AB Science SA announced the signing of an exclusive licensing agreement for conducting research on the prevention and treatment of humans infected with nidoviruses, coronaviruses and picornaviruses.
[AB Science SA (Globe Newswire, Inc.)] |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | NIH National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States |
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| | The University of Warwick – Coventry, England, United Kingdom |
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| | IPBS-Toulouse – Toulouse, France |
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