 | | Vol. 9.15 – 21 April, 2021 |
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| Scientists demonstrated the capacity of a subunit vaccine, comprising the SARS-CoV-2 spike receptor binding domain displayed on a protein nanoparticle, to stimulate robust and durable neutralizing antibody responses and protection against SARS-CoV-2 in non-human primates.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators identified an emerging SARS-CoV-2 variant by viral whole-genome sequencing of 2,172 nasal/nasopharyngeal swab samples from 44 counties in California.
[Cell] |
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| Scientists highlight the coordinated immune response that contributed to COVID-19 pathogenesis and revealed discrete cellular components that could be targeted for therapy.
[Nature Medicine] |
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| Researchers report that another emergent variant from Brazil, P.1, was not only refractory to multiple neutralizing monoclonal antibodies, but also more resistant to neutralization by convalescent plasma and vaccinee sera.
[Cell Host & Microbe] |
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| The authors compared SARS-CoV-2 sequences from natural and experimental mustelid infections and identified two surface glycoprotein spike mutations associated with mustelids.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators showed that classically activated M1 alveolar macrophages (AMs) facilitated viral spread; however, alternatively activated M2 AMs limited the spread.
[Cell Discovery] |
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| Researchers identified distinct signatures of microbial dysbiosis among severely ill COVID-19 patients on broad spectrum antimicrobial therapy.
[Cell Discovery] |
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| The authors describe the efforts to utilize an mRNA platform for rational design and evaluations of mRNA vaccine candidates based on the spike glycoprotein of SARS-CoV-2.
[npj Vaccines] |
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| Investigators showed preclinical data for our clinical candidate CVnCoV, a lipid nanoparticle-encapsulated mRNA vaccine that encoded full-length, pre-fusion stabilized SARS-CoV-2 spike protein.
[npj Vaccines] |
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| Scientists found that human iPS cells expressing the SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) could be infected with SARS-CoV-2. In infected ACE2-iPS cells, the expression of SARS-CoV-2 nucleocapsid protein, budding of viral particles, production of progeny virus, double membrane spherules, and double-membrane vesicles were confirmed.
[iScience] |
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| MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
| | The authors showed that pediatric Pandemrix-associated NT1 patients had enhanced T-cell immunity against the viral epitopes, neuraminidase 175–189 and nucleoprotein 214–228.
[Nature Communications] |
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| Researchers showed that suitable nucleic acid was sufficient to trigger a dynamic transformation of VP40 dimer into the octameric ring.
[Cell Reports] |
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| Scientists examined the role of Mint3 in macrophages, which promoted glycolysis via hypoxia-inducible factor-1 activation, during the initiation of pyroptosis following Listeria monocytogenes infection.
[Cell Death & Disease] |
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| The authors review the precedent for passive immunization and lessons learned from using antibody therapies for viral infections such as respiratory syncytial virus, Ebola virus and SARS-CoV infections.
[Nature Reviews Immunology] |
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| Trevena, Inc. announced that TRV027, the company’s novel AT1 receptor selective agonist, has been selected for inclusion in an international, multi-site, adaptive, Phase II-Phase III trial in COVID-19 patients.
[Trevena, Inc. (Globe Newswire, Inc.)] |
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| May 10 – 15, 2021
Virtual |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | NIH National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States |
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| | The University of Warwick – Coventry, England, United Kingdom |
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| | IPBS-Toulouse – Toulouse, France |
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