 | | Vol. 9.16 – 28 April, 2021 |
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| In a cohort of 417 persons who had received the second dose of BNT162b2 or mRNA-1273 vaccine at least two weeks previously, scientists identified two women with vaccine breakthrough infection.
[New England Journal of Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| A single dose of Ad26.COV2.S protected against symptomatic Covid-19 and asymptomatic SARS-CoV-2 infection and was effective against severe–critical disease, including hospitalization and death.
[New England Journal of Medicine] |
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| Scientists combined B cell sorting with single-cell VDJ and RNA-seq and mAb structures to characterize B cell responses against SARS-CoV-2.
[Cell] |
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| The authors showed that stabilization of different Spike conformations led to modulation of Spike-mediated membrane fusion, with profound implications in COVID-19 pathology and immunity.
[Cell] |
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| Researchers investigated SARS-CoV-2 antibody and T cell responses in matched samples of COVID-19 convalescent individuals up to six months post-infection.
[Science Translational Medicine] |
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| Exposure of human induced pluripotent stem cell (iPSC)–derived heart cells to SARS-CoV-2 revealed productive infection and robust transcriptomic and morphological signatures of damage, particularly in cardiomyocytes.
[Science Translational Medicine] |
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| Investigators showed that the polybasic insertion endows SARS-CoV-2 with a selective advantage in lung cells and primary human airway epithelial cells, but impaired replication in Vero E6, a cell line used for passaging SARS-CoV-2.
[Nature Microbiology] |
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| The authors investigated m6A modification of SARS-CoV-2 gene in regulating host cell innate immune response.
[Cell Reports] |
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| Scientists report that co-culture of human cells expressing the receptor ACE2 with cells expressing SARS-CoV-2 spike, resulted in synapse-like intercellular contacts that initiated cell-cell fusion, producing syncytia resembling those they identified in lungs of COVID-19 patients.
[eLife] |
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| Investigators demonstrated that SARS-CoV-2 infection induced a type I IFN response in vitro and in moderate cases of COVID-19.
[iScience] |
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| Researchers describe the identification of several monoclonal antibodies that target SARS-CoV-2 Spike protein. One human antibody, CA521FALA, demonstrated neutralization potential by immunizing human antibody transgenic mice.
[Communications Biology] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| The authors used RNA sequencing to define, in a mouse model, the metabolic states of wild-type C. difficile and of an isogenic mutant that lacks toxins.
[Nature] |
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| Scientists mapped the responses of Pseudomonas aeruginosa to treatment in high definition during a lung infection of a single ICU patient.
[Nature Communications] |
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| Immune-related manifestations are increasingly recognized conditions in patients with COVID-19, with around 3,000 cases reported worldwide comprising more than 70 different systemic and organ-specific disorders. Although the inflammation caused by SARS-CoV-2 infection is predominantly centred on the respiratory system, some patients can develop an abnormal inflammatory reaction involving extrapulmonary tissues.
[Nature Reviews Rheumatology] |
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| The authors review how maternal NK cells balance their double duty both in the local microenvironment of the uterus and systemically, during toxoplasmosis, influenza, cytomegalovirus, malaria and other infections that threat pregnancy.
[Mucosal Immunology] |
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| Organicell Regenerative Medicine, Inc. announced that the company has completed enrollment for its FDA granted expanded access trial for Zofin for the treatment of COVID-19.
[Organicell Regenerative Medicine, Inc.] |
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| May 17 – 21, 2021
Virtual |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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| | NIH National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States |
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| | The University of Warwick – Coventry, England, United Kingdom |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | IPBS-Toulouse – Toulouse, France |
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