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| Proteomic deconvolution of the immunoglobulin G (IgG) repertoire to the spike glycoprotein in convalescent subjects revealed that the response was directed predominantly against epitopes residing outside the receptor-binding domain.
[Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| | | Investigators analyzed T and B cell responses after first dose vaccination with the Pfizer/BioNTech mRNA vaccine BNT162b2 in healthcare workers followed longitudinally, with or without prior Wuhan-Hu-1 SARS-CoV-2 infection.
[Science] |
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| Scientists evaluated SARS-CoV-2 antibody dynamics over ten months in 963 individuals who predominantly experienced mild COVID-19.
[Cell Host & Microbe] |
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| Investigators assessed the magnitude, function and phenotype of SARS-CoV-2-specific CD4 T cells in 95 hospitalized COVID-19 patients and 38 non-COVID-19 patients, using flow cytometry.
[Journal of Clinical Investigation] |
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| The authors tested SARS-CoV-2-specific T-cell (CοV-2-ST) immunity and expansion in unexposed donors, COVID-19 infected individuals, asymptomatic PCR-positive subjects, vaccinated individuals, non-ICU hospitalized patients, and ICU patients.
[Clinical Infectious Diseases] |
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| Researchers analyzed antibody responses in a cohort of 55 convalescent patients and isolated 54 potent neutralizing monoclonal antibodies.
[Cell Reports] |
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| Investigators showed that SARS-CoV-2 proteins synergized to counteract antiviral immune responses. For example, Nsp14 targeted the type I interferon receptor for lysosomal degradation, ORF3a prevented fusion of autophagosomes and lysosomes, and ORF7a interfered with autophagosome acidification.
[Cell Reports] |
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| The authors present a 2.9-Ã… resolution cryo-electron microscopy structure of the complex between the ACE2 receptor and N501Y spike protein ectodomains that shows Y501 inserted into a cavity at the binding interface near Y41 of ACE2.
[PLoS Biology] |
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| Researchers report the isolation, characterization and recombinant production of 12 neutralizing human monoclonal antibodies, targeting three distinct epitopes on the spike N-terminal domain of the virus.
[iScience] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Deletion of Notch4 in Treg cells or therapy with anti-Notch4 antibodies in conventional and humanized mice normalized the dysregulated innate immunity and rescued disease morbidity and mortality induced by a synthetic analog of viral RNA or by influenza H1N1 virus.
[Immunity] |
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| By applying bioinformatics analysis to mass cytometry-phenotyped specimens from individuals with viremia and in vitro-infected cells from uninfected donors, scientists provide an atlas of the phenotypes of in vivo and in vitro HIV-susceptible cells.
[Cell Reports] |
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| Investigators demonstrated that T cell phenotypic signatures associate with viral reservoir size in a cohort of HIV vertically infected children and young adults under durable viral control, and who initiated anti-retroviral therapy under two years old.
[PLoS Pathogens] |
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| Researchers characterized the constituent monocyte and lymphocyte populations between macaque species, and profile other major immune cell subsets including: CD4+ and CD8+ T cells, NK cells, B cells, monocyte subsets and myeloid dendritic cells.
[Scientific Reports] |
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| The authors summarize the current understanding of immune responses to and immune control of SARS-CoV-2 and the implications for prevention of reinfection.
[Nature Reviews Immunology] |
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| Scientists summarize the effects of TTP-mediated regulation of mRNA stability in dendritic cells (DCs), focusing on DC maturation and antigen presentation, T cell activation and differentiation, immune tolerance and inflammation.
[RNA Biology] |
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| Indian researchers say they urgently need better access to data collected by government agencies to help them understand and fight the country’s devastating second pandemic wave. An open letter published on April 29 has 740 signatories so far asks the government for access to databases on COVID-19 testing and genomic sequencing and urges it to remove other obstacles to research.
[ScienceInsider] |
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| PhysIQ Inc., Johns Hopkins University, Duke University and The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. announced their collaboration to deploy physIQ’s platform to support a clinical trial to evaluate investigational products for early treatment and post-exposure prophylaxis of COVID-19.
[PhysIQ, Inc.] |
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| Ocugen, Inc. announced that in a new study, scientists at Indian Council of Medical Research-National Institute of Virology have found that COVAXIN demonstrated potential effectiveness against the Brazil variant of SARS-CoV-2, B.1.128.2.
[Ocugen, Inc.] |
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| | Pfizer – Pearl River, New York, United States |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | NIH National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States |
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| | The University of Warwick – Coventry, England, United Kingdom |
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