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| Across some heterogeneity in tumor type, stage, and treatment, virus-exposed solid cancer patients displayed a dominant impact of SARS-CoV-2, apparent from the resemblance of their immune signatures to those for COVID-19+ non-cancer patients
[Cancer Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The presence of neutralizing antibodies within the first weeks from symptoms onset correlated with time to a negative swab result, while the lack of neutralizing capacity correlated with an increased risk of a fatal outcome.
[Nature Communications] |
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| Scientists found target site duplications flanking the viral sequences and consensus LINE1 endonuclease recognition sequences at the integration sites, consistent with a LINE1 retrotransposon-mediated, target-primed reverse transcription and retroposition mechanism.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| SARS-CoV-2 spike-specific IgG memory B cells were evaluated in a randomly selected group of COVID-19 recovering subjects by reversed B-cell FluroSpot based on human IgG SARS-CoV-2 receptor-binding domain.
[Clinical Microbiology and Infection] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Researchers treated 50 patients with Severe combined immunodeficiency due to adenosine deaminase (ADA) with an investigational gene therapy composed of autologous CD34+ hematopoietic stem and progenitor cells transduced ex vivo with a self-inactivating lentiviral vector encoding human ADA.
[New England Journal of Medicine] |
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| Investigators reported the dynamics of 18 important immune parameters, related to clinical, genetic and virological factors, in influenza patients across different severity levels.
[Nature Communications] |
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| CD34+ cells derived in vitro from induced pluripotent stem (iPS) cells genetically modified to carry the CCR5Δ32 mutant alleles did not engraft in humanized immunodeficient mice.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors report its effect at birth and on antibody-mediated immune responses to a DTaP-IPV-HB-PRP~T vaccine in preterm compared to term infants.
[Clinical infectious Diseases] |
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| Researchers found significant infiltration of IL-17-secreting CD4+ tissue-resident memory T cells and Siglec-F+ neutrophils into the nasal tissue during primary infection with B. pertussis.
[Mucosal Immunology] |
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| Since inflammation is known to facilitate HIV sexual transmission, researchers investigated the role of hyaluronic acid in genital mucosal fibroblast-mediated enhancement of HIV infection.
[Mucosal Immunology] |
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| Investigators showed that mitofusin-2, a mitochondrial fusion protein, promoted innate host defense through the maintenance of aerobic glycolysis and xenophagy via hypoxia-inducible factor-1α during intracellular bacterial infection.
[Communications Biology] |
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| The authors summarize the current understanding of immune responses to and immune control of SARS-CoV-2 and the implications for prevention of reinfection.
[Nature Reviews Immunology] |
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| Scientists summarize the effects of TTP-mediated regulation of mRNA stability in dendritic cells (DCs), focusing on DC maturation and antigen presentation, T cell activation and differentiation, immune tolerance and inflammation.
[RNA Biology] |
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| The World Health Organization (WHO) was too cautious in communicating the risks of COVID-19 early last year, according to the first major investigation of the global pandemic response. Had it been bolder, and had nations heeded its guidance, the pandemic might have been curtailed, say the authors of the report.
[Nature News] |
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| Pfizer, Inc. and BioNTech SE announced that the FDA has expanded the Emergency Use Authorization for their COVID-19 vaccine to include individuals 12 to 15 years of age. This is the first COVID-19 vaccine authorized in the US for use in this age group.
[Pfizer, Inc.] |
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| With the pandemic now deep into its second year, it’s clear the crisis has exposed major weaknesses in the production and use of research-based evidence- failures that have inevitably cost lives.
[Nature News] |
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| | Trinity College Dublin – Dublin, Republic of Ireland |
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| | Pfizer – Pearl River, New York, United States |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | NIH National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States |
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