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| Overall, 2260 adolescents 12 to 15 years of age received injections; 1131 received BNT162b2, and 1129 received placebo.
[New England Journal of Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Colchicine is an oral anti-inflammatory medication beneficial in gout, pericarditis, and coronary disease. Researchers investigated the effect of colchicine on the composite of COVID-19-related death or hospital admission.
[Lancet] |
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| Scientists reported on the development of a highly efficacious mRNA vaccine, SW0123 that is composed of sequence-modified mRNA encoding the full-length SARS-CoV-2 Spike protein packaged in core–shell structured lipopolyplex nanoparticles.
[Signal Transduction and Targeted Therapy] |
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| Using Syrian hamsters that modeled moderate to severe COVID-19 disease, the authors demonstrated the high efficacy of PiN-21 to prevent and treat SARS-CoV-2 infection.
[Science Advances] |
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| Using a comprehensive translational approach, researchers unraveled the virological and immunological responses following treatment to disentangle which COVID-19 patients may benefit and should be the focus of future studies.
[Nature Communications] |
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| Investigators hypothesized that divergent infection outcomes were a natural result of mutual negative feedbacks between pathogens and the host immune response.
[Proceedings of the Royal Society B-Biological Sciences] |
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| Researchers ivestigated the immune response in acute or convalescent COVID19 patients. They characterized the peripheral blood mononuclear cells using flow cytometry and found that CD8+ T cells were significantly subsided in moderate COVID-19 and convalescent patients.
[Heliyon] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| The authors characterized the human immune response to natural Crimean-Congo hemorrhagic fever virus infection to identify potent neutralizing monoclonal antibodies targeting the viral glycoprotein.
[Cell] |
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| Scientists showed that E3 ubiquitin ligase TRIM7 is a cell-intrinsic antiviral effector that restricted multiple human enteroviruses by targeting viral 2BC, a membrane remodeling protein, for ubiquitination and proteasome-dependent degradation.
[Cell] |
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| Investigators showed remarkably similar transcriptional profiles for atypical B cells (ABCs) clusters in malaria, HIV, and autoimmune diseases and demonstrated that interferon-γ drove the expansion of ABCs in malaria.
[Science Advances] |
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| Researchers profiled the host immunotranscriptome response in humans before, during, and after infection with a partially attenuated rDEN2Δ30 challenge virus.
[Nature Communications] |
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| Investigators examined whether lung lung-resident memory B cells cells were elicited by the respiratory pathogen pneumococcus, were present in humans, and were important in pneumonia defense
[Journal of Clinical Investigation] |
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| Scientists characterized the metabolic and transcriptional responses of murine macrophages to Mycobacterium tuberculosis in order to disentangle the underlying mechanisms.
[Cell Reports] |
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| The authors investigated the role of the versatile posttranslational modification persulfidation for both fungal virulence and antifungal host defense.
[PLoS Biology] |
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| Investigators summarize the literature on mutations of the SARS-CoV-2 spike protein, the primary antigen, focusing on their impacts on antigenicity and contextualizing them in the protein structure, and discuss them in the context of observed mutation frequencies in global sequence datasets.
[Nature Reviews Microbiology] |
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| With COVID-19 suppression measures like mask wearing, school closures, and travel restrictions driving flu transmission rates to historically low levels around the world, it appears that one of the H3N2 clades may have disappeared — gone extinct.
[STAT News] |
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| Kedrion Biopharma and Kamada Ltd. announced that the FDA has approved a label update for KEDRAB®, a human rabies immune globulin, establishing the product’s safety and effectiveness in children.
[Kamada Ltd.] |
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| June 28 – 30, 2021
Virtual |
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| | Uppsala University – Uppsala, Sweden |
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| | Salk Institute – La Jolla, California, United States |
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| | The University of Edinburgh – Edinburgh, Scotland, United Kingdom |
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| | Rochester Regional Health – Rochester, New York, United States |
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| | The Journal of Infectious Diseases – Arlington, Virginia, United States |
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