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| Investigators described HIV-1 Env Fab-dimerized glycan-reactive broadly neutralizing Ab without VH-swapped domains from simian-human immunodeficiency virus-infected macaques.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Unexposed patients with hematological malignancies presented with reduced prevalence of pre-existing SARS-CoV-2 cross-reactive CD4+ T cell responses and signs of T cell exhaustion when compared to solid tumor patients and healthy volunteers.
[Cancer Discovery] |
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| Investigators reported the humoral immune response to circulating SARS-CoV-2 variants, such as 501Y.V2, of the plasma and neutralizing antibodies elicited by CoronaV, ZF2001 and natural infection.
[Cell Research] |
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| The authors recently reported a SARS-CoV-2 human Fc-conjugated receptor-binding domain mRNA vaccine delivered via lipid nanoparticles.
[ACS Nano] |
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| Scientists identified circulating virus-specific T cell responses during acute infection with functional, migratory and apoptotic patterns modulated by viral proteins and associated with clinical outcome.
[Nature Communications] |
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| The authors obtained serum and saliva samples from groups of vaccinated, infected and uninfected individuals and characterize the antibody response to receptor binding domain mutant strains.
[Nature Communications] |
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| Researchers provided substantial evidence for the effect of BNT162b2 mRNA vaccine versus native infection on maternal humoral, as well as transplacentally acquired fetal immune response, potentially providing newborn protection.
[Journal of Clinical Investigation] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Scientists employed murine cytomegalovirus as a model to study the consequences of viral infection on pregnancy outcome and fertility maintenance.
[Immunity] |
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| The authors integrated single-cell RNA and surface protein data from 500,089 memory T cells to define 31 cell states from 259 individuals in a Peruvian tuberculosis progression cohort.
[Nature Immunology] |
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| Investigators hypothesized that bacterial/fungal pathogens triggering RA-synthesizing (RALDH) activity in dendritic cells fueled HIV reservoir establishment/outgrowth in pathogen-reactive CD4+ T cells.
[Journal of Immunology] |
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| The authors hypothesized that divergent infection outcomes were a natural result of mutual negative feedbacks between pathogens and the host immune response.
[Proceedings of the Royal Society B-Biological Sciences] |
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| Scientists investigated the role of ascorbic acid, calcitriol, retinoic acid, and alfa-tocopherol as inductors of molecules related to mycobacterial contention in macrophages and epithelial cells.
[Peptides] |
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 |
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| Investigators review how epitopes identified throughout the SARS-CoV-2 proteome reveal significant correlation between number of epitopes defined and size of the antigen provenance.
[Cell Host & Microbe] |
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| Since the SARS-CoV-2 variant known as B.1.617 was first reported in India late last year, it has spread to dozens of other countries— including the United States, Singapore and the United Kingdom, where it has become dominant in some regions.
[Nature News] |
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| Emergent BioSolutions, Inc. announced two-year persistence data from its Phase II clinical study evaluating the safety and immunogenicity of the company’s investigational chikungunya virus virus-like particle vaccine candidate in 415 healthy adults.
[Emergent BioSolutions, Inc.] |
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| June 21 – 22, 2021
Virtual |
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| | The University of Edinburgh – Edinburgh, Scotland, United Kingdom |
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| | Rochester Regional Health – Rochester, New York, United States |
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| | The Journal of Infectious Diseases – Arlington, Virginia, United States |
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| | Kings’s College London – London, England, United Kingdom |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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