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| Scientists profiled vaccine-induced polyclonal antibodies as well as plasmablast derived mAbs from individuals who received SARS-CoV-2 spike mRNA vaccine.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors identified 24 full-length coronavirus genomes, including four novel SARS-CoV-2 related and three SARS-CoV related viruses.
[Cell] |
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| Researchers interrogated the brain stem and olfactory bulb in COVID-19 patients postmortem using imaging mass cytometry to understand the local immune response at a spatially resolved, high-dimensional single-cell level and compared their immune map to non-COVID respiratory failure, multiple sclerosis and control patients.
[Immunity] |
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| Investigators showed that early-phase SARS-CoV-2 spike protein–specific immunoglobulin G (IgG) in serum of critically ill COVID-19 patients induced excessive inflammatory responses by human alveolar macrophages.
[Science Translational Medicine] |
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| Researchers reported evidence that the olfactory neuroepithelium was a major site of SARS-CoV2 infection with multiple cell types, including olfactory sensory neurons, support cells, and immune cells, becoming infected.
[Science Translational Medicine] |
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| The authors report ed cryo-EM structures of both trimeric spike ectodomains in complex with the 47D11 Fab. 47D11 bound to the closed receptor-binding domain, distal to the ACE2 binding site.
[Science Advances] |
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| Scientists demonstrated that despite the large size of the viral RNA genome, infectious full-length cDNA was readily assembled in vitro by a circular polymerase extension reaction methodology without the need for technically demanding intermediate steps.
[Nature Communications] |
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| To understand the structural basis for SARS-CoV-2 viral-host protein recognition, investigators used cryo-electron microscopy to determine a complex structure of the human cell junction protein PALS1 and SARS-CoV-2 viral envelope protein.
[Nature Communications] |
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| The authors reported SARS-CoV-2 spike ΔH69/V70 in multiple independent lineages, often occurring after acquisition of the receptor binding motif replacements such as N439K and Y453F known to increase binding affinity to the ACE2 receptor and confer antibody escape.
[Cell Reports] |
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| Comparison of the transcriptomes of the bronchoalveolar microenvironment and peripheral blood indicates alveolar macrophages, alveolar epithelial cells, and monocytes in lungs as the potential main sources of elevated cytokines mediating systemic immune responses and organ damages.
[Cell Discovery] |
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| Scientists showed that Hantaan viruses (HTNV) could infect CD8+ T cells in vivo in patients diagnosed with hemorrhagic fever with renal syndrome.
[Communications Biology] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| In co-cultures, investigators found that Streptomyces altered the fungal acetylome leading to substantial induction of fungal autophagy.
[Microbiome] |
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| Researchers showed that CDT induced premature senescence in activated CD4 T cells in vitro and provided evidence suggesting that infection with genotoxin-producing bacteria promoted T cell senescence in vivo.
[Cell Reports] |
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| Scientists explore the involvement of diverse mechanisms, including trained immunity, and their relevance for infections and cardiovascular disease, as these prevalent conditions are heavily influenced by immune cell abundance and phenotypic adaptions.
[Immunity] |
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| Investigators discuss the recent advancement in understanding the molecular events during SARS-CoV-2 entry which would contribute to developing vaccines and therapeutics.
[Trends in Biochemical Sciences] |
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| The authors provide an overview of neutrophil characteristics, their classic effector functions, as well as more recently described antibody-mediated effector functions.
[Viruses-Basel] |
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| Twist Bioscience Corporation announced that it has started shipping its synthetic RNA reference controls for the SARS-CoV-2 Kappa variant strain.
[Twist Bioscience Corporation] |
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| Researchers have been monitoring how COVID-19 vaccinations perform to determine whether booster shots will be needed, as variants of the novel coronavirus continue to mutate and spread. Now, the NIH announced they are beginning a Phase I/II clinical trial to test the safety and efficacy of different booster schedules.
[National Institutes of Health] |
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| June 21 – 26, 2021
Virtual |
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| | University of Washington – Seattle, Washington, United States |
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| | Uppsala University – Uppsala, Sweden |
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| | The University of Edinburgh – Edinburgh, Scotland, United Kingdom |
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| | Salk Institute – La Jolla, California, United States |
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| | Rochester Regional Health – Rochester, New York, United States |
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