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Vol. 9.24 – 30 June, 2021
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Single-cell ATAC-seq analysis revealed an epigenomically distinct subcluster of monocytes with reduced chromatin accessibility at AP-1-targeted loci after vaccination.
[Cell]
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PUBLICATIONSRanked by the impact factor of the journal
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SARS-CoV-2-naı̈ve individuals achieved levels similar to mild natural infection after the first vaccination; a second dose generated levels approaching severe natural infection.
[ACS Nano]
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With the rising burden of the pandemic, it is vital to identify not only active disease but any post-recovery complications as well. This study was conducted with the aim of identifying the presence of post-viral symptomatology in patients recovered from mild COVID-19 disease.
[Signal Transduction and Targeted Therapy]
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SARS-CoV-2-infected cells showed accumulation of key metabolites, activation of autophagy inhibitors and reduction of proteins responsible for autophagy initiation, membrane nucleation, and phagophore formation, as well as autophagosome-lysosome fusion.
[Nature Communications]
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Researchers identified two public clonotypes of IGHV3-53/3-66 receptor binding domain antibodies with a 9-residue complementarity-determining region H3 that paired with different light chains.
[Nature Communications]
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The authors described an engineered human virus receptor, ACE2, by mutagenesis and screening for binding to the receptor binding domain.
[Nature Communications]
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The efficacy of spike encoding mRNA vaccines against the ancestral strain and the VOC B.1.351 was tested in a K18-hACE2 transgenic mouse model. Naive mice and mice immunized with a formalin-inactivated SARS-CoV-2 preparation were used as controls.
[Nature Communications]
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Investigating SARS-CoV-2 infection in tissue culture, researchers found that the protease TMPRSS2 determined the entry pathway used by the virus.
[EMBO Journal]
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Scientists determined the x-ray structures of the SARS-CoV-2 2′-O-methyltransferase in complex with its reaction substrates, products, and divalent metal cations.
[Science Signaling]
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In lieu of tissue samples, the authors measured cytokines, inflammatory markers, viral RNA, microbiome composition, and antibody responses in stool samples from a cohort of 44 hospitalized COVID-19 patients.
[Scientific Reports]
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MORE IMMUNOLOGY OF INFECTIOUS DISEASE
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Investigators studied a patient with inherited PD-1 deficiency and tuberculosis who died of pulmonary autoimmunity. The patient’s leukocytes did not express PD-1 or respond to PD-1-mediated suppression.
[Nature Medicine]
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Scientists investigated the single-cell phenotypes associated with antimicrobial responses in human leprosy granulomas by applying single-cell and spatial sequencing to leprosy biopsy specimens.
[Nature Immunology]
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Researchers showed that nasal infection controls two sequential processes to induce neutralizing IgG antibodies recognizing the hemagglutinin of heterotypic strains.
[Nature Communications]
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By combining single-cell RNA and B cell receptor sequencing of antigen-specific cells in lymph nodes, spleen, and lungs after influenza infection in mice, the authors identified several germinal center B cell subpopulations and organ-specific differences that persisted over the course of the response.
[Cell Reports]
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Scientists showed that viral infection attenuated the expression of genes related to lipid metabolism in murine CD4+ T cells, which in turn increased the expression of antiviral genes.
[Communications Biology]
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Researchers demonstrated that prostaglandin E2 (PGE2) exerted a potent immunosuppressive action during the immune response of the human host against Mycobacterium tuberculosis infection.
[Scientific Reports]
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HIV host genomic research, which aims to understand how human genetic variation affects our response to HIV infection, has progressed from early candidate gene studies to recent multi-omic efforts, benefiting from spectacular advances in sequencing technology and data science.
[Nature Reviews Genetics]
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Tiziana Life Sciences plc announced that it has signed an agreement with FHI Clinical, a global clinical contract research organization, to conduct a Phase II Proof-of-concept study in Brazil to evaluate the safety, tolerability and efficacy of intranasal Foralumab in hospitalized patients with COVID-19 and pulmonary inflammation.
[Tiziana Life Sciences plc]
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Venatorx Pharmaceuticals announced that the first patient was dosed in a Phase I clinical trial evaluating VNRX-9945, a highly potent, broadly active viral replication inhibitor for the treatment of chronic hepatitis B virus infection.
[Venatorx Pharmaceuticals]
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Moderna, Inc. announced that the government of India has issued a registration certificate and a permission to import the COVID-19 Vaccine Moderna for restricted use in an emergency situation.
[Moderna, Inc.]
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September 1 – 4, 2021
Virtual
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The European Molecular Biology Laboratory – Barcelona, Spain
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Hummingbird Bioscience – Singapore, Singapore
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University of Gothenburg – Gothenburg, Sweden
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Brigham and Women’s Hospital – Boston, Massachusetts, United States
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University of Washington – Seattle, Washington, United States
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