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| Investigators applied structure-based network analysis and assessments of HLA class I-peptide stability to define mutationally constrained CD8+ T cell epitopes across the SARS-CoV-2 proteome.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| To elucidate the immunopathology underlying COVID-19 severity, researchers performed cytokine and multiplex immune profiling in COVID-19 patients.
[Nature Communications] |
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| The authors conducted a 12-month longitudinal study through collecting a total of 1,782 plasma samples from 869 convalescent plasma donors in Wuhan, China and tested specific antibody responses
[Nature Communications] |
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| The Co-Stars study prospectively enrolled 3679 healthcare workers to comprehensively characterize the kinetics of SARS-CoV-2 spike, receptor-binding-domain and nucleoprotein antibodies in parallel.
[Clinical Infectious Diseases] |
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| When comparing nasopharyngeal swabs from cancer and noncancer patients for RT-qPCR cycle thresholds measuring acute respiratory SARS-CoV-2 in 1063 patients, researchers found that malignant disease favored the magnitude and duration of viral RNA shedding concomitant with prolonged serum elevations of type 1 IFN that anticorrelated with anti-RBD IgG antibodies.
[Cell Death & Differentiation] |
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| Antibody immunoreactivity against SARS-CoV-2 antigens and Spike variants, inhibition of Spike-driven virus–cell fusion, and infectious SARS-CoV-2 neutralization were characterized in 807 serial samples.
[PLOS Medicine] |
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| Scientists generated a series of deuterated variants of a 3CLpro inhibitor, GC376, and evaluated the antiviral effect against SARS-CoV-2.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors investigated the antiviral activities of long-chain polyPs against SARS-CoV-2 infection.
[Science Signaling] |
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| Researchers demonstrated that intranasal inoculation with SARS-CoV-2 induced robust viral replication in the olfactory epithelium, not the olfactory bulb, resulting in transient olfactory dysfunction in humanized ACE2 mice.
[Cell Discovery] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Scientists demonstrated that precursors of exhausted T cells sustained mitochondrial fitness, including high spare respiratory capacity, while exhausted effector T cells deteriorated metabolically over time.
[Immunity] |
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| Investigators detected rapid, dynamic changes in translocated microbial constituents during two years after cART initiation.
[Cell] |
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| An in silico approach was adopted to construct a multi-epitope vaccine from selected immunogenic extracellular vesicle proteins to elicit a cellular as well as a humoral immune response.
[Scientific Reports] |
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| Scientists identify the mechanisms of protection as well as correlates of protection is crucially important to inform further vaccine development and guide the use of licensed COVID-19 vaccines worldwide.
[Nature Reviews Immunology] |
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| The authors discuss the latest developments in the immunopathological characteristics of COVID-19 and focus on cytokine storm including the current research status of the different cytokines involved.
[Signal Transduction and Targeted Therapy] |
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| SAB Biotherapeutics announced that the first participant has been dosed in its Phase IIa clinical trial evaluating the safety and efficacy of SAB-176 in a human challenge study.
[SAB Biotherapeutics] |
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| August 1 – 2, 2021
Brisbane, Australia |
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| | Roswell Park – Colorado Springs, Colorado, United States |
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| | Hummingbird Bioscience – Singapore, Singapore |
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| | University of Gothenburg – Gothenburg, Sweden |
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| Brigham and Women’s Hospital – Boston, Massachusetts, United States |
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| | University of Washington – Seattle, Washington, United States |
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