Immunology of Infectious Disease News Volume 9.27 | Jul 21 2021

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    2021-07-21 | IIDN 9.27


    Immunology of Infectious Disease News by STEMCELL Technologies
    Vol. 9.27 – 21 July, 2021
    TOP STORY

    Broad Sarbecovirus Neutralization by a Human Monoclonal Antibody

    Scientists described a human monoclonal antibody, designated S2X259, recognizing a highly conserved cryptic receptor-binding domain epitope and cross-reacting with spikes from all sarbecovirus clades.
    [Nature]

    AbstractFull Article

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    PUBLICATIONSRanked by the impact factor of the journal

    Interferon-Armed RBD Dimer Enhances the Immunogenicity of RBD for Sterilizing Immunity against SARS-CoV-2

    To enhance antigen processing and cross-presentation in draining lymph nodes, researchers developed an interferon-armed receptor-binding domain dimerized by an immunoglobulin fragment.
    [Cell Research]

    Full Article

    Generation of Glucocorticoid-Resistant SARS-CoV-2 T Cells for Adoptive Cell Therapy

    The authors expanded SARS-CoV-2 T cells from the peripheral blood of COVID-19-recovered donors and non-exposed controls using different culture conditions.
    [Cell Reports]

    Full ArticleGraphical Abstract

    SARS-CoV-2 Variant B.1.617 Is Resistant to Bamlanivimab and Evades Antibodies Induced by Infection and Vaccination

    Scientists analyzed whether B.1.617 is more adept in entering cells and/or evades antibody responses. B.1.617 entered two of eight cell lines tested with roughly 50% increased efficiency and was equally inhibited by two entry inhibitors.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Dendritic Cell Deficiencies Persist Seven Months after SARS-CoV-2 Infection

    Researchers described that in addition to dendritic cell (DC) deficiency, several DC activation and homing markers were altered in acute COVID-19 patients, which were associated with multiple inflammatory markers.
    [Cellular & Molecular Immunology]

    Abstract

    Three Epitope-Distinct Human Antibodies from RenMab Mice Neutralize SARS-CoV-2 and Cooperatively Minimize the Escape of Mutants

    Investigators utilized RenMab, a novel mouse carrying the entire human antibody variable region, for neutralizing antibody discovery.
    [Cell Discovery]

    Full Article

    Danshensu Alleviates Pseudo-Typed SARS-CoV-2 Induced Mouse Acute Lung Inflammation

    Scientists investigated the antiviral effects of a Salvia miltiorrhiza compound, Danshensu, in vitro and in vivo, including the mechanism of S protein-mediated virus attachment and entry into target cells.
    [Acta Pharmacologica Sinica]

    Full Article

    Intranasal plus Subcutaneous Prime Vaccination with a Dual Antigen COVID-19 Vaccine Elicits T-Cell and Antibody Responses in Mice

    The authors demonstrated subcutaneous (SC) prime and SC boost vaccination of CD-1 mice with a dual-antigen vaccine elicits T-helper cell 1 biased T-cell and humoral responses to both spike (S) and nucleocapsid that were greater than those seen with human adenovirus serotype 5 S wild type delivering only unmodified S.
    [Scientific Reports]

    Full Article

    BATF Regulates Progenitor to Cytolytic Effector CD8+ T Cell Transition during Chronic Viral Infection

    Researchers demonstrated that CX3CR1+ effector cells bore a striking similarity to short-lived effector cells during acute infection.
    [Nature Immunology]

    Abstract

    MX2-Mediated Innate Immunity against HIV-1 Is Regulated by Serine Phosphorylation

    Investigators demonstrated that serine phosphorylation of the N-terminal domain at positions 14, 17 and 18 suppressed myxovirus resistance 2 (MX2) antiviral function, prevented interactions with the HIV-1 capsid and nuclear transport factors, and was reversed by myosin light chain phosphatase.
    [Nature Microbiology]

    Abstract

    MARCH8 Inhibits Influenza A Virus Infection by Targeting Viral M2 Protein for Ubiquitination-Dependent Degradation in Lysosomes

    Scientists demonstrated that membrane-associated RING-CH 8, E3 ubiquitin protein ligase (MARCH8) profoundly inhibited influenza A virus replication both in vitro and in mice.
    [Nature Communications]

    Full Article

    Probiotic Supplementation Reduces Inflammatory Profiles but Does Not Prevent Oral Immune Perturbations during SIV Infection

    Researchers revealed that similar to the GI mucosae, oral CD4+ T cells were rapidly depleted, and as one of the first comprehensive analyses of the oral microflora in SIV infection, they also observed significant modulation among two genera, Porphyromonas and Actinobacillus, early after infection.
    [Scientific Reports]

    Full Article

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    REVIEWS

    The Success of SARS-CoV-2 Vaccines and Challenges Ahead

    The rapid and remarkably successful development, manufacture, and deployment of several effective SARS-CoV-2 vaccines is now tempered by three key challenges.
    [Cell Host & Microbe]

    Full Article

    INDUSTRY AND POLICY NEWS

    Japan Becomes First Country to Approve Ronapreve (Casirivimab and Imdevimab) for the Treatment of Mild to Moderate COVID-19

    Roche announced that Japan’s Ministry of Health, Labour and Welfare has approved Ronapreve™, for the treatment of patients with mild to moderate COVID-19 via intravenous infusion.
    [Roche (GlobeNewswire, Inc.)]

    Press Release

    Enzo Biochem Receives FDA Emergency Use Authorization for Rapid Extraction Method on Proprietary Test System for Detection of Coronavirus SARS-CoV-2

    Enzo Biochem, Inc. announced that it has received an expansion of its FDA Emergency Use Authorization for the company’s rapid extraction method on its proprietary test system for the detection of coronavirus SARS-CoV-2 including the genetic variants that are now proliferating globally.
    [Enzo Biochem, Inc. (GlobeNewswire, Inc.)]

    Press Release

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    JOB OPPORTUNITIES

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    Johns Hopkins University – Baltimore, Maryland, United States

    Senior Research Scientist/Principal Scientist – Immunology

    Hummingbird Bioscience – Singapore, Singapore

    Postdoctoral Fellow – Vascular Dysfunction in SARS-CoV-2

    The European Molecular Biology Laboratory – Barcelona, Spain

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