 | | Vol. 9.28 – 28 July, 2021 |
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| Researchers performed single cell RNA-sequencing on nasopharyngeal swabs from 58 healthy and COVID-19 participants. During COVID-19, they observed expansion of secretory, loss of ciliated, and epithelial cell repopulation via deuterosomal expansion.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Spike-specific CD8 T cell levels after heterologous vaccination were significantly higher than after homologous regimens. Spike-specific T cells were predominantly polyfunctional with largely overlapping cytokine-producing phenotypes in all three regimens.
[Nature Medicine] |
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| Investigators used single-cell RNA sequencing to identify and profile SARS-CoV-2-reactive T cells from COVID-19 patients.
[Nature Communications] |
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| Researchers characterized the neutralizing activity of post-Sputnik V vaccination sera against the ensemble of S mutations present in alpha and beta variants of concern.
[Nature Communications] |
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| Investigators showed that the nucleocapsid of SARS-CoV-2 inhibited host pyroptosis by blocking Gasdermin D cleavage. SARS-CoV-2-infected monocytes showed enhanced cellular interleukin 1b (IL-1b) expression, but reduced IL-1b secretion.
[EMBO Journal] |
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| The authors tested small molecule inhibitors that targeted the PI3 kinase VPS34 or fatty acid metabolism for anti-SARS-CoV-2 activity. Their studies determined that compounds targeting VPS34 were potent SARS-CoV-2 inhibitors.
[Cell Reports] |
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| Researchers demonstrated that serum from 58 COVID-19 patients could induce complement-mediated cell death in a functional assay and increase membrane attack complex deposition on the cell surface.
[Haematologica] |
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| Scientists designed and produced ConVac, a replication-competent vesicular stomatitis virus vaccine vector that expressed the S1 subunit of SARS-CoV-2 spike protein.
[npj Vaccines] |
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| To investigate the specific role of T cells in recovery from SARS-CoV-2 infections, researchers studied rhesus macaques that were depleted of either CD4+, CD8+, or both T cell subsets prior to infection.
[mBio] |
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| The authors aimed to decipher SARS-CoV-2 infected cell types, the consequent host immune response and their interplay in lung of COVID-19 patients.
[EBiomedicine] |
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| Using a novel SARS-Cov-2-specific artificial antigen presenting cell, coupled with a rapid expansion protocol as practiced in tumor infiltrating lymphocytes therapy, scientists generated an immune catalytic quantity of VIL.
[Scientific Reports] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| The authors confirmed pervasive phenotypic, functional and transcriptional differences between memory and exhausted antigen-specific CD8+ T cells in human hepatitis C virus infection before and after treatment.
[Nature Immunology] |
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| Researchers investigated the impact of IL-27 in both autophagy induction and HIV-1 infection in macrophages.
[Scientific Reports] |
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| Mucosal vaccines offer the potential to trigger robust protective immune responses at the predominant sites of pathogen infection. The identification of safe and effective mucosal adjuvants allied to innovative antigen discovery and delivery strategies is key to advancing mucosal vaccines.
[Nature Reviews Immunology] |
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| Ottawa researchers have been awarded more than $8 million to lead four national studies in pursuit of answers about how well COVID-19 vaccines work in people with cancer and other health conditions.
[Ottawa Citizen] |
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| September 21 – 24, 2021
Virtual |
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| | University of California Irvine – Irvine, California, United States |
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| Johns Hopkins University – Baltimore, Maryland, United States |
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| | Hummingbird Bioscience – Singapore, Singapore |
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| | University of Basel – Basel, Switzerland |
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| | Tübingen University – Tuebingen, Germany |
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