 | | Vol. 9.29 – 4 August, 2021 |
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| The authors initiated a prospective Phase IV controlled trial in 910 adults with autoimmune rheumatic diseases and 182 age- and sex-frequency-matched healthy adults who received two doses of CoronaVac.
[Nature Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists analyzed six independent groups of clonally related SARS-CoV-2 spike receptor-binding domain-specific antibodies from five individuals shortly after infection and later in convalescence to determine the impact of maturation over months.
[Immunity] |
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| Investigators inspected sex differences in SARS-CoV-2 infection, hospitalization, admission to the intensive care unit, sera inflammatory biomarker profiling, and single-cell RNA-sequencing profiles across nasal, bronchoalveolar lavage fluid, and peripheral blood mononuclear cells from COVID-19 patients with varying degrees of disease severities.
[Signal Transduction and Targeted Therapy] |
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| Scientists reported SARS-CoV-2 specific T cell responses in infected adults and children and found that the acute and memory CD4+ T cell responses to structural SARS-CoV-2 proteins increased with age, whereas CD8+ T cell responses increased with time post-infection.
[Nature Communications] |
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| The authors studied spike-specific antibody responses following first and/or second COVID-19 vaccination in 299 patients with chronic lymphocytic leukemia compared with healthy donors.
[Blood Cancer Journal] |
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| Researchers investigated the seroprevalence and the quantity of SARS-CoV-2 antibodies in a cohort of patients with multiple sclerosis or neuromyelitis optica spectrum disorders.
[Journal of Neurology, Neurosurgery & Psychiatry ] |
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| Investigators used samples from health care workers to perform a longitudinal analysis of the antibody responses using a research-grade receptor binding domain and spike based enzyme-linked immunosorbent assay, and a commercial nucleoprotein based chemiluminescent microparticle immunoassay.
[iScience] |
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| Key elements for viral pathogenesis include viral strains, viral load, co-infection, and host responses, and the authors sought to understand how these four key components interplay in a cohort of COVID-19 patients.
[Scientific Reports] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Researchers showed that SAMHD1 was SUMOylated on residue K595, a modification that relied on the presence of a proximal SUMO-interacting motif.
[Nature Communications] |
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| Scientists investigated gene delivery approaches via recombinant adeno-associated virus and simian immunodeficiency virus vectors to achieve sustained in vivo production of palivizumab in a murine model.
[Scientific Reports] |
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| The authors review the emerging roles of complex organoids in the study of SARS-CoV-2 infection, modeling of COVID-19 disease pathology and in drug, antibody and vaccine development.
[Nature Cell Biology] |
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| Moderna, Inc. announced that the FDA has granted Fast Track designation for mRNA-1345, its investigational single-dose mRNA vaccine against RSV in adults older than 60 years of age.
[Moderna, Inc.] |
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| September 27 – October 1, 2021
Orlando, Florida, United States |
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| | University of California Irvine – Irvine, California, United States |
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| Johns Hopkins University – Baltimore, Maryland, United States |
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| | Hummingbird Bioscience – Singapore, Singapore |
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| | University of Basel – Basel, Switzerland |
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| | Dalhousie University – Halifax, Nova Scotia, Canada |
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