Immunology of Infectious Disease News Volume 9.31 | Aug 18 2021

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    2021-08-18 | IIDN 9.31


    Immunology of Infectious Disease News by STEMCELL Technologies
    Vol. 9.31 – 18 August, 2021
    TOP STORY

    Durability of mRNA-1273 Vaccine–Induced Antibodies against SARS-CoV-2 Variants

    Scientists assessed the impact of SARS-CoV-2 variants B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma), B.1.429 (Epsilon), B.1.526 (Iota), and B.1.617.2 (Delta) on binding, neutralizing, and ACE2-competing antibodies elicited by the vaccine mRNA-1273 over seven months.
    [Science]

    Full Article

    View tips on how to organize your lab notebooks, references and protocols.
    PUBLICATIONSRanked by the impact factor of the journal

    Rapid Induction of Antigen-Specific CD4+ T Cells Is Associated with Coordinated Humoral and Cellular Immune Responses to SARS-CoV-2 mRNA Vaccination

    Researchers performed longitudinal antigen-specific T cell analyses on healthy SARS-CoV-2 naïve and recovered individuals prior to and following mRNA prime and boost vaccination.
    [Immunity]

    AbstractFull ArticleGraphical Abstract

    A Vaccine-Induced Public Antibody Protects against SARS-CoV-2 and Emerging Variants

    Scientists analyzed receptor binding domain-binding monoclonal antibodies derived from SARS-CoV-2 mRNA vaccine-elicited germinal center B cells for neutralizing activity against the WA1/2020 D614G SARS-CoV-2 strain and variants of concern.
    [Immunity]

    AbstractGraphical Abstract

    Intranasal ChAdOx1 nCoV-19/AZD1222 Vaccination Reduces Viral Shedding after SARS-CoV-2 D614G Challenge in Preclinical Models

    The authors investigated whether intranasally administered ChAdOx1 nCoV-19 reduces detection of virus in nasal swabs after challenging vaccinated macaques and hamsters with SARS-CoV-2 carrying a D614G mutation in the spike protein.
    [Science Translational Medicine]

    Full Article

    Protective Antibodies Elicited by SARS-CoV-2 Spike Protein Vaccination Are Boosted in the Lung after Challenge in Nonhuman Primates

    Soluble prefusion-stabilized spike protein trimers from SARS-CoV-2 were formulated with the adjuvant AS03 and administered twice to nonhuman primates.
    [Science Translational Medicine]

    Full Article

    HIF-1α Promotes SARS-CoV-2 Infection and Aggravates Inflammatory Responses to COVID-19

    Investigators identified that SARS-CoV-2 ORF3a and host hypoxia-inducible factor-1α (HIF-1α) play key roles in the virus infection and pro-inflammatory responses.
    [Signal Transduction and Targeted Therapy]

    Full Article

    Combining Spike- and Nucleocapsid-Based Vaccines Improves Distal Control of SARS-CoV-2

    The authors interrogated whether SARS-CoV-2 vaccines could be improved by incorporating nucleocapsid as an antigen.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Potent Prophylactic and Therapeutic Efficacy of Recombinant Human ACE2-FC against SARS-CoV-2 Infection In Vivo

    Researchers developed recombinant human ACE2-Fc fusion protein (hACE2-Fc) and a hACE2-Fc mutant with reduced catalytic activity.
    [Cell Discovery]

    Full Article

    Offspring Born to Influenza A Virus Infected Pregnant Mice Have Increased Susceptibility to Viral and Bacterial Infections in Early Life

    Scientists investigated whether maternal influenza infection had adverse effects on immune responses in offspring.
    [Nature Communications]

    Full Article

    Rapid Selection of HIV Envelopes That Bind to Neutralizing Antibody B Cell Lineage Members with Functional Improbable Mutations

    Researchers demonstrated that less complex B cell evolutionary pathways than those naturally observed existed for the induction of HIV bnAbs by vaccination, and they established rational approaches to identify boosting candidate immunogens.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Facts Vs. claims. Three scientists peer reviewed a life science vendor to get to the truth. See for yourself.
    REVIEWS

    Distinguishing Features of Current COVID-19 Vaccines: Knowns and Unknowns of Antigen Presentation and Modes of Action

    The authors review the relevance of structural modifications of S in different vaccines and the different modes of antigen expression after vaccination with genetic adenovirus-vector and mRNA vaccines.
    [npj Vaccines]

    Full Article

    INDUSTRY AND POLICY NEWS

    MyOwnMed Partners with National Institutes of Health to Identify Long-Term Consequences of COVID-19 Infection and Recovery

    My Own Med, Inc. is playing an important role in support of the new NIH IMPACC (IMmunoPhenotyping Assessment in a COVID-19 Cohort) study.
    [My Own Med, Inc. (BusinessWire, Inc.)]

    Full Article

    FEATURED EVENT

    Vitamin D Workshop

    October 13 – 14, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – HIV Infection

    University Hospital Heidelberg – Heidelberg, Germany

    Investigator – Host Immunity and Microbiome

    National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States

    Principal Bioinformatician – Bacterial Infections

    Wellcome Trust Sanger Institute – Cambridge, England, United Kingdom

    Postdoctoral Scholar – Immunology, Cancer Immunotherapy, and Protein Engineering

    University of California Irvine – Irvine, California, United States

    Postdoctoral Research Fellow – Viral and Bacterial Lung Infections

    Johns Hopkins University – Baltimore, Maryland, United States

    > See All Jobs

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