 | | Vol. 9.32 – 25 August, 2021 |
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| Scientists provided data showing that potent cross-clade pan-sarbecovirus neutralizing antibodies were induced in survivors of SARS-CoV-1 infection who had been immunized with the BNT162b2 messenger RNA vaccine.
[New England Journal of Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators screened a library of 1900 clinically safe drugs against OC43, a human beta coronavirus that causes the common cold, and evaluated the top hits against SARS-CoV-2.
[Science] |
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| Researchers isolated E1-specific human monoclonal antibodies with diverse patterns of recognition for alphaviruses (ranging from Eastern equine encephalitis virus -specific to alphavirus cross-reactive) from survivors of natural Eastern equine encephalitis virus infection.
[Cell] |
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| Scientists identified DC2.112 and DC2.315, two pan-protective yet poorly neutralizing human monoclonal antibodies that avidly bind to viral antigen on the surface of cells infected with arthritogenic and encephalitic alphaviruses.
[Cell] |
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| The authors found that mRNA and protein expression of angiotensin-converting enzyme 2, the cell entry receptor for the novel SARS-CoV-2 that causes COVID-19, increased with advancing age in distal lung epithelial cells.
[Science Advances] |
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| Investigators identified twelve potentially functional structural elements within the SARS-CoV-2 genome, observed that subgenomic RNAs could form different structures, and that WT and Δ382 virus genomes folded differently.
[Nature Communications] |
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| The authors reported a high-resolution atlas of the translatome and transcriptome of SARS-CoV-2 for various time points after infecting human cells.
[Nature Communications] |
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| Researchers found increased mouse IL-33 expression in CD8+ T cells following cell activation via anti-CD3/CD28 stimulation in vitro or Lymphocytic choriomeningitis virus infection in vivo.
[Immunology] |
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| Scientists showed that SARS-CoV-2 could establish a robust infection in HEK293T cells that overexpressed human angiotensin-converting enzyme 2 without triggering significant host immune response.
[Scientific Reports] |
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| MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
| | The authors used whole-genome sequencing to compare avian IAV H7N9 patients with healthy controls and observed a strong association between H7N9 infection and rare, heterozygous single-nucleotide variants in the MX1 gene.
[Science] |
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| Researchers reported that acute orthohantavirus infection increases the level of Ig free light chains in serum of both hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome patients, and that the increase correlated with the severity of acute kidney injury in HFRS.
[PLOS Pathogens] |
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| In vitro analysis of macrophage and dendritic cell function revealed deficits in phagocytosis and increased cytokine production upon bacterial stimulation that was, in part, due to increased NF-κB signaling.
[Journal of Immunology] |
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| The authors describe the technologies that underlie mRNA vaccines, with an emphasis on lipid nanoparticles and other non-viral delivery vehicles.
[Nature Reviews Drug Discovery] |
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| | The FDA announced the approval of the Pfizer-BioNTech COVID-19 vaccine, making it the first fully approved COVID-19 vaccine in the country, according to a statement from the federal agency.
[The Scientist] |
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| | Pfizer, Inc. and BioNTech SE announced the initiation of a supplemental Biologics License Application to the FDA for the approval of a booster dose of COMIRNATY® to prevent COVID-19 in individuals 16 years of age and older.
[Pfizer, Inc. (BusinessWire, Inc.)] |
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| | Moderna, Inc. announced it has completed the rolling submission process for its Biologics License Application to the FDA for the full licensure of the Moderna COVID-19 Vaccine for active immunization to prevent COVID-19 in individuals 18 years of age and older.
[Moderna, Inc.] |
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| | | October 13 – 14, 2021
London, England, United Kingdom |
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| | | | | Cleveland Clinic – Port Saint Lucie, Florida, United States |
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| | | University Hospital Heidelberg – Heidelberg, Germany |
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| | | Wellcome Trust Sanger Institute – Cambridge, England, United Kingdom |
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| | Johns Hopkins University – Baltimore, Maryland, United States |
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| | | University of California Irvine – Irvine, California, United States |
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