 | | Vol. 9.33 – 1 September, 2021 |
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| Investigators showed that C-type lectin receptors, DC-SIGN, L-SIGN and the sialic acid-binding Ig-like lectin 1 function as attachment receptors by enhancing ACE2-mediated infection and modulating the neutralizing activity of different classes of spike-specific antibodies.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors revealed that tensile force, generated by bending of the host cell membrane, strengthened spike recognition of ACE2 and accelerated the detachment of spike’s S1 subunit from the S2 subunit to rapidly prime the viral fusion machinery.
[Cell Research] |
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| Scientists performed an integrated analysis of SARS-CoV-2 spike-specific antibodies, cytokines, viral load and bacterial communities in paired nasopharyngeal swabs and plasma samples from a cohort of clinically distinct patients with COVID-19 during acute infection.
[Nature Immunology] |
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| The authors demonstrated that targeting the receptor-binding domainof the SARS-CoV-2 spike protein to CD40 induced significant levels of specific T and B cells, with long-term memory phenotypes, in a humanized mouse model.
[Nature Communications] |
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| Investigators demonstrated that prime or prime-boost administration of mRNA-1273 in hamsters elicited robust neutralizing antibodies, ameliorated weight loss, suppressed SARS-CoV-2 replication in the airways, and better protected against disease at the highest prime-boost dose.
[Journal of Clinical Investigation] |
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| Scientists reported the development of an intranasal subunit vaccine that uses lyophilized spike protein and liposomal STING agonist as an adjuvant.
[iScience] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| By sensing IL-2 and cross-presenting hepatocellular antigens, a subset of kupffer cells overcame the tolerogenic potential of the hepatic microenvironment, suggesting new strategies for boosting hepatic T cell immunity.
[Immunity] |
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| The authors investigated the effect of ABX464 on HIV transcription and total and intact HIV DNA in CD4+ T cells from antiretroviral therapy-suppressed participants enrolled in the ABIVAX-005 clinical trial.
[Clinical Infectious Diseases] |
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| Using multiple Plasmodium species, genetically modified parasites, and combinations of host genetic and pharmacologic approaches, researchers found that the deposition of the malarial pigment hemozoin directly limited the abundance and capacity of conventional type 1 dendritic cells to prime helper T cell responses.
[Cell Reports] |
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| Scientists reported the development of an improved system for monitoring HIV-1 fate at single-cell and population levels and showed the diverse applications of this system to study specific aspects of HIV-1 fate in different cell types and under different environments.
[Cell Reports] |
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| Utilizing two models of pulmonary bacterial infection combined with multi-omic approaches, researchers identified persistent, pathogen-specific changes to the lung lipidome that correlated with differences in the trained immune response against a third unrelated pathogen.
[iScience] |
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| Scientists summarize insights into the proviral host factors that are required for SARS-CoV-2 infection that were mainly obtained using functional genetic and interactome screens.
[Nature Microbiology] |
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| The authors review the works that have elucidated the function of SARS-CoV-2-specific T cells in patients and in vaccinated individuals.
[Cellular & Molecular Immunology] |
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| HDT Bio Corp. announced that they will co-develop HDT Bio’s RNA COVID-19 vaccine, HDT-301, in Brazil. Brazil’s National Health Surveillance Agency (Anvisa) has authorized Phase I clinical trials of HDT-301.
[HDT Bio Corp. (BusinessWire, Inc.)] |
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| October 19 – 22, 2021
Aarhus, Denmark |
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| University of Colorado – Aurora, Colorado, United States |
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| | University of Miami – Miami, Florida, United States |
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| University of North Dakota – Grand Forks, North Dakota, United States |
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| | Cleveland Clinic – Port Saint Lucie, Florida, United States |
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| | Wellcome Trust Sanger Institute – Cambridge, England, United Kingdom |
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